FDA Approves Antibiotic Combination for Complicated UTIs
(MedPage Today) -- The FDA approved the combination of cefepime and enmetazobactam (Exblifep) for the treatment of adult patients with complicated urinary tract infections, including pyelonephritis. The agency's decision was based on data from... (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - February 24, 2024 Category: OBGYN Source Type: news

Cefepime-Taniborbactam Superior to Meropenem for Complicated UTI
THURSDAY, Feb. 15, 2024 -- For adults with complicated urinary tract infection (UTI), including acute pyelonephritis, cefepime-taniborbactam is superior to meropenem, according to a study published in the Feb. 15 issue of the New England Journal of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 15, 2024 Category: Pharmaceuticals Source Type: news

Venatorx Pharmaceuticals Announces FDA Acceptance and Priority Review of New Drug Application for Cefepime-Taniborbactam to Treat Complicated Urinary Tract Infections (cUTI), including Pyelonephritis, in Adults
Cefepime-taniborbactam has also demonstrated in vitro activity against CDC Urgent and Serious Threat Pathogens carbapenem-resistant Enterobacterales, multidrug-resistant Pseudomonas aeruginosa and Extended Spectrum Beta-lactamase-producing... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - August 15, 2023 Category: Drugs & Pharmacology Source Type: news

Cefepime/Enmetazobactam Noninferior for Complicated UTI
TUESDAY, Oct. 11, 2022 -- For patients with complicated urinary tract infection (UTI) or acute pyelonephritis caused by gram-negative pathogens, cefepime/enmetazobactam is noninferior and superior to piperacillin/tazobactam for clinical cure and... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 11, 2022 Category: Pharmaceuticals Source Type: news

Wockhardt initiates phase-III clinical study of new antibiotic candidate
WCK 5222 is a drug, which is entirely a new class of antibiotic known as " β-lactam ENHANCER", and is targeted for treatment of hospitalised adults with complicated urinary tract infections, including acute pyelonephritis, Wockhardt said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - August 16, 2022 Category: Pharmaceuticals Source Type: news

Tebipenem Pivoxil Hydrobromide Noninferior to Ertapenem for UTI
THURSDAY, April 7, 2022 -- For patients with complicated urinary tract infection or acute pyelonephritis, tebipenem pivoxil hydrobromide is noninferior to intravenous ertapenem, according to a study published in the April 7 issue of the New England... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - April 7, 2022 Category: Pharmaceuticals Source Type: news

Oral Option for Complicated UTI Passes Phase III Test
(MedPage Today) -- An investigational oral antibiotic, tebipenem pivoxil hydrobromide, was just as effective as intravenous ertapenem for hospitalized patients with complicated urinary tract infections (UTIs) or acute pyelonephritis, a phase III... (Source: MedPage Today OB/GYN)
Source: MedPage Today OB/GYN - April 6, 2022 Category: OBGYN Source Type: news

Spero Therapeutics Submits New Drug Application to U.S. FDA for Tebipenem HBr for the Treatment of Complicated Urinary Tract Infections including Pyelonephritis
CAMBRIDGE, Mass., Oct. 28, 2021 (GLOBE NEWSWIRE) -- Spero Therapeutics, Inc. (Nasdaq: SPRO), a multi-asset clinical-stage biopharmaceutical company focused on identifying, developing and commercializing treatments in high unmet need areas involving... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - October 28, 2021 Category: Drugs & Pharmacology Source Type: news

Procalcitonin to Reduce Long-Term Infection-associated Adverse Events in Sepsis. A Randomized Trial, American journal of respiratory and critical care medicine 203(2): 202-210.
Rationale: Although early antimicrobial discontinuation guided by procalcitonin (PCT) has shown decreased antibiotic consumption in lower respiratory tract infections, the outcomes in long-term sepsis sequelae remain unclear. Objectives: To investigate if PCT guidance may reduce the incidence of long-term infection-associated adverse events in sepsis. Methods: In this multicenter trial, 266 patients with sepsis (by Sepsis-3 definitions) with lower respiratory tract infections, acute pyelonephritis, or primary bloodstream infection were randomized (1:1) to receive either PCT-guided discontinuation of antimicrobials or stand...
Source: Current Awareness Service for Health (CASH) - February 19, 2021 Category: Consumer Health News Source Type: news

What Causes Lethargy?
Discussion Lethargy is a common word used to describe a person who is drowsy, sluggish, listless and apathetic. Concentration may be difficult and they may have problems doing simple tasks. Many people actual mean fatigue or lassitude or being more tired when they use the word. In medical terms, lethargy is usually used to describe patients who have some type of excessive tiredness and usually have mental status changes with decreased alertness or arousal. Patients and health care providers both usually qualify the term and give more description to better communicate what is implied when using the term. This is true of man...
Source: PediatricEducation.org - January 25, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Causes Neutropenia?
Discussion Neuropenia is defined as a neutrophil count < 1500/µL. It is classified as mild from 1000-1500/µL, moderate from 500-1000/µL, and severe if < 500/µL. It is not uncommonly seen in the setting of acute self-limited infections, and with re-testing returns to normal. It is also not uncommon at certain ages, such as perinatally, especially in premature infants (up to 6%) . It is also common in certain ethnic groups particularly African American or Arabic populations where up to 10% of the children may have mild neutropenia which does not cause clinical disease. The overall prevalence a...
Source: PediatricEducation.org - March 2, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Drug Trials Snapshot: FETROJA
FETROJA is used to treat adults who have a complicated urinary tract infection (abbreviated as cUTI) including infection of the kidneys (pyelonephritis) caused by specific bacteria. It should be used only when few or no other treatment options are available. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - December 4, 2019 Category: Drugs & Pharmacology Authors: FDA Source Type: news

Predicting need for intensive care unit admission in adult emphysematous pyelonephritis patients at emergency departments: comparison of five scoring systems
This study assesses the performance of National Early Warning Score (NEWS), Quick Sepsis-related Organ Failure Assessment (qSOFA), Modified Early Warning Score (MEWS), Rapid Emergency Medicine Score (REMS), and Rapid Acute Physiology Score (RAPS) in predicting emphysematous pyelonephritis (EPN) patients ' need for intensive care unit (ICU) admission. A retrospective analysis was conducted at four training and research hospitals ' emergency departments (EDs) on all EPN adult patients from January 2007 to August 2017. In this multicentre ED EPN series, we recommend using NEWS in early identification of critical EPN patients ...
Source: Current Awareness Service for Health (CASH) - November 28, 2019 Category: Consumer Health News Source Type: news

FDA OKs New Antibacterial Cefiderocol for Complicated UTI FDA OKs New Antibacterial Cefiderocol for Complicated UTI
Last month, an FDA panel recommended approval of cefiderocol for treatment of complicated urinary tract infections (cUTIs), including pyelonephritis caused by Gram-negative bacteria.FDA Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - November 15, 2019 Category: Drugs & Pharmacology Tags: Infectious Diseases News Alert Source Type: news