This Under-Utilized Drug Is Actually Critical for Treatment-Resistant Depression

Many people with clinical depression have tried an array of medication and still feel sick. Maybe they’ve tried different selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Maybe they’ve taken these antidepressants along with an antipsychotic (a common strategy to boost effectiveness). Either way, the lack of improvement can make individuals feel even more hopeless and fear the darkness will never lift. If this sounds all-too familiar, you’re definitely not alone. In fact, up to 30 percent of people with depression don’t respond to the first few antidepressants they try. Many individuals with treatment-resistant depression may benefit from a class of antidepressants that today is rarely offered to them: monoamine oxidase inhibitors or MAOIs. “MAOIs are the best antidepressants on the planet,” said Mark D. Rego, M.D., a psychiatrist with 23 years of experience, specializing in treatment-resistant individuals, and an assistant clinical professor of psychiatry at Yale University School of Medicine. Dr. Rego has seen incredible changes in patients with severe depression who were struggling with profound anxiety, insomnia, and suicidal thoughts and taking strong doses of antipsychotic medication and SSRIs. After taking an MAOI, their symptoms “vanished.” After her husband passed away, Sue Trupin fell into a deep depression that lasted 3 years. During this time, she tried over 10 d...
Source: Psych Central - Category: Psychiatry Authors: Tags: Antidepressants Depression Disorders ECT General Medications Treatment Atypical Depression difficult to treat depression Managing Depression MAOIs medication for depression Monoamine Oxidase Inhibitors Severe Depression Treatin Source Type: news

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Hi all, I've been having a lot of anxiety regarding a critical decision I made several years prior. When I was a senior in high school, I received admission to a school that now ranks among the Top 3 public universities in the United States. Although I did receive a small scholarship (several thousand), it would have put me into significant debt. I instead opted for a much smaller school (which ranks between 150-200) that was generous enough to endow me with a full-tuition merit... Dealing with Anxiety as a Pre-Med
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
AbstractPurposeTo evaluate the effects of epiretinal membrane (ERM) formation on the anatomic and functional results of subjects with diabetic macular edema (DME) who are receiving intravitreal aflibercept injections (IAIs).Materials and methodsThis retrospective comparative study includes 29 eyes with DME (Group 1) and 43 eyes with DME and ERM (Group 2). After three consecutive monthly 2.0  mg IAIs, subjects received monthly follow-ups and retreatment was performed if needed. Corrected visual acuity (CVA), central macular thickness (CMT), and central macular volume (CMV) parameters were recorded tri-monthly, and the ...
Source: International Ophthalmology - Category: Opthalmology Source Type: research
Authors: Chopra A, Bhat SG, Sivaraman K Abstract is an obligate, asaccharolytic, gram-negative bacteria commonly associated with increased periodontal and systemic inflammation. P. gingivalis is known to survive and persist within the host tissues as it modulates the entire ecosystem by either engineering its environment or modifying the host's immune response. It interacts with various host receptors and alters signaling pathways of inflammation, complement system, cell cycle, and apoptosis. P. gingivalis is even known to induce suicidal cell death of the host and other microbes in its vicinity with the emergence ...
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
Publication date: Available online 19 September 2020Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Salvatore Di Paolo, Marco Fiorentino, Luca De Nicola, Gianpaolo Reboldi, Loreto Gesualdo, Federica Barutta, Andrea Natali, Giuseppe Penno, Paola Fioretto, Giuseppe Pugliese, Italian Society of Nephrology and the Italian Diabetes Society
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
This study aimed to explore the quantitative differences between common OHRA models. METHODS: The risk ratios (RRs) in five typical industries (leather, wooden furniture manufacturing, printing and dyeing, printing, and garment manufacturing) were investigated using six OHRA models, namely the models from the US Environmental Protection Agency (EPA), Singapore, the Control of Substances Hazardous to Health (COSHH), Australia, Romania, and International Council on Mining and Metals (ICMM). The consistency, correlation, and reliability were evaluated for quantitative differences between the models. RESULTS: The order...
Source: Journal of Occupational Health - Category: Occupational Health Tags: J Occup Health Source Type: research
Authors: Ossareh S, Bagheri M, Abbasi M, Abolfathi S, Bohlooli A Abstract INTRODUCTION: Seven months after the emergence of SARS-COV-2 virus, there is paucity of data regarding the epidemiology of the virus in hemodialysis patients. We aim to present the results of the screening program implied after outbreak of COVID-19 in a referral hemodialysis ward. METHODS: We started clinical screening and obligatory mask wearing for dialysis patients and personnel on 20-Feb-2020. However 11 symptomatic COVID-19 patients emerged till day +36. On days +39 and +40 a screening program was implied including measurement of SAR...
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
CONCLUSION: In the current study, the patient's albuminuria, type of treatment and HbA1c had no effect on the RI. The study also found that an increase in the RI index could be a significant predictor of renal dysfunction and increased creatinine. PMID: 32943590 [PubMed - in process]
Source: Iranian Journal of Kidney Diseases - Category: Urology & Nephrology Tags: Iran J Kidney Dis Source Type: research
TYPE 2 diabetes occurs when the body becomes resistant to the hormone insulin; as a consequence, blood sugar levels keep rising. When they're dangerously high, you may notice shiny, smooth skin on a certain body part.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 20 September 2020Source: Journal of Biomedical InformaticsAuthor(s): Meghan Reading Turchioe, Marissa Burgermaster, Elliot G. Mitchell, Pooja M. Desai, Lena Mamykina
Source: Journal of Biomedical Informatics - Category: Information Technology Source Type: research
AbstractPsychometric data linking of psychological and behavioral questionnaires can facilitate the harmonization of data across HIV and substance use cohorts. Using data from the Collaborating Consortium of Cohorts Producing NIDA Opportunities (C3PNO), we demonstrate how to capitalize on previous linking work with a common linked depression metric across multiple questionnaires. Cohorts were young men who have sex with men (MSM), substance-using MSM, HIV/HCV cocaine users, and HIV-positive patients. We tested for differential item functioning (DIF) by comparing C3PNO cohort data with general population data. We also fit a...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
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