UCLA researchers unlock protein key to harnessing regenerative power of blood stem cells

In this study, the authors showed that a cell surface protein called protein tyrosine phosphatase-sigma (PTP-sigma) regulates the critical process called engraftment, which is how HSCs start to grow and make healthy blood cells after transplantation. Mamle Quarmyne, a graduate student Chute’s lab and first author of the study, demonstrated that PTP-sigma is produced (expressed) on a high percentage of mouse and human HSCs. She showed further that genetic deletion of PTP-sigma in mice markedly increased the ability of HSCs to engraft in transplanted mice.  In a complementary study, Quarmyne demonstrated that selection of human blood HSCs which did not express PTP-sigma led to a 15-fold increase in HSC engraftment in transplanted immune-deficient mice. Taken together, these studies showed that PTP-sigma suppresses normal HSC engraftment capacity and targeted blocking of PTP-sigma can substantially improve mouse and human HSC engraftment after transplantation. Chute and colleagues showed further that PTP-sigma regulates HSC function by suppressing a protein, RAC1, which is known to promote HSC engraftment after transplantation.    “These findings have tremendous therapeutic potential since we have identified a new receptor on HSCs, PTP-sigma, which can be specifically targeted as a means to potently increase the engraftment of transplanted HSCs in patients,” said Chute, senior author of the study and professor of hematology/oncology and...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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ConclusionInitiating CI in patients with proven immediate hypersensitivity to CA or OX appeared to be safe in our study.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
The Internet of Things is driving incredible innovation in healthcare. “Almost any new innovative medical device is currently designed as a part of broader interconnected system,” Rami Muleys, head of application security business development at Positive Technologies, told MD+DI. “The main value of IoT is the convergence between different systems and the ability to exchange data between every device – from an insulin pump to a hospital bed.” Healthcare is consequently “a constantly changing landscape, especially sinc...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Source Type: news
BackgroundSinonasal malignancies are a rare subset of head and neck tumors, and surveillance strategies after definitive tumor treatment are often generalized from those for overall head and neck cancer outcomes data. However, recent literature suggests that the posttreatment period in sinonasal cancer is fundamentally different and a more tailored surveillance approach may be beneficial. Although rates of symptomatology are high in head and neck cancer recurrence and patient ‐driven follow‐up is common, rates of symptomatology are unknown in sinonasal cancer specifically.MethodsPatients with recurrence of sinonasal ma...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Abstract Although, as the major organ of gas exchange, the lung is considered a nonlymphoid organ, an interconnected network of lung-resident innate cells, including epithelial cells, dendritic cells, macrophages, and natural killer cells is crucial for its protection. These cells provide defense against a daily assault by airborne bacteria, viruses, and fungi, as well as prevent the development of cancer, allergy, and the outgrowth of commensals. Our understanding of this innate immune environment has recently changed with the discovery of a family of innate lymphoid cells (ILCs): ILC1s, ILC2s, and ILC3s. All lac...
Source: Annual Review of Physiology - Category: Physiology Authors: Tags: Annu Rev Physiol Source Type: research
Conclusion: To the best of our knowledge, this is the first report of nivolumab-induced CRS in a patient with gastric cancer.Case Rep Oncol 2019;12:147 –156
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Chien Lin Resveratrol (tran-3,5,4′-trihydroxystibene, RSV) is a kind of polyphenol which has anti-inflammatory, antioxidant, anti-allergy, and anti-cancer properties, as well as being a scavenger of free radicals and preventing cardiovascular diseases. However, it is quite unstable in light, heat, and other conditions, and decays easily due to environmental factors. For these reasons, this study used a new type of carrier, transfersome, to encapsulate RSV. Transfersome consists of phosphatidyl choline (PC) from a liposomal system and non-ionic edge activators (EA). EA are an important ingredient in the formul...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
FDA said it has received reports of 457 unique cancer cases related to breast implants since 2010, including nine patient deaths. The agency identified those unique cases from a total of 660 adverse event reports in the U.S. from 2010 through September 2018, including 246 new adverse event reports since 2017. FDA began reporting on cases of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a type of non-Hodgkin’s lymphoma and a known risk from breast implants, in 2011. The new total of reports is larger than the number of unique cases because patients, providers, and manufacturers may all repo...
Source: Mass Device - Category: Medical Devices Authors: Tags: Blog Featured Food & Drug Administration (FDA) Implants News Well Oncology Women's Health Allergan Center for Devices and Radiological Health (CDRH) Source Type: news
Abstract Resident memory T (Trm) cells stably occupy tissues and cannot be sampled in superficial venous blood. Trm cells are heterogeneous but collectively constitute the most abundant memory T cell subset. Trm cells form an integral part of the immune sensing network, monitor for local perturbations in homeostasis throughout the body, participate in protection from infection and cancer, and likely promote autoimmunity, allergy, and inflammatory diseases and impede successful transplantation. Thus Trm cells are major candidates for therapeutic manipulation. Here we review CD8+ and CD4+ Trm ontogeny, maintenance, ...
Source: Annual Review of Immunology - Category: Allergy & Immunology Authors: Tags: Annu Rev Immunol Source Type: research
About 1.1 million Americans currently live with HIV, and approximately 40,000 are infected each year, according to federal data. But in his State of the Union address, President Donald Trump promised to “eliminate the HIV epidemic in the United States within 10 years” — a plan that hinges on a multi-agency push for better diagnosis, treatment and prevention in at-risk communities, health officials said Wednesday. Trump introduced the plan during his annual address on Tuesday but offered few details. Health officials fleshed out the plan during a call with reporters on Wednesday. The initiative will be ove...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime HIV/AIDS onetime Source Type: news
Publication date: February 2019Source: Seminars in Cell &Developmental Biology, Volume 86Author(s): Solana Alculumbre, Salvatore Raieli, Caroline Hoffmann, Rabie Chelbi, François-Xavier Danlos, Vassili SoumelisAbstractPlasmacytoid pre-dendritic cells (pDC) are a specialized DC population with a great potential to produce large amounts of type I interferon (IFN). pDC are involved in the initiation of antiviral immune responses through their interaction with innate and adaptive immune cell populations. In a context-dependent manner, pDC activation can induce their differentiation into mature DC able to induce both...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
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