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UCLA researchers unlock protein key to harnessing regenerative power of blood stem cells

In this study, the authors showed that a cell surface protein called protein tyrosine phosphatase-sigma (PTP-sigma) regulates the critical process called engraftment, which is how HSCs start to grow and make healthy blood cells after transplantation. Mamle Quarmyne, a graduate student Chute’s lab and first author of the study, demonstrated that PTP-sigma is produced (expressed) on a high percentage of mouse and human HSCs. She showed further that genetic deletion of PTP-sigma in mice markedly increased the ability of HSCs to engraft in transplanted mice.  In a complementary study, Quarmyne demonstrated that selection of human blood HSCs which did not express PTP-sigma led to a 15-fold increase in HSC engraftment in transplanted immune-deficient mice. Taken together, these studies showed that PTP-sigma suppresses normal HSC engraftment capacity and targeted blocking of PTP-sigma can substantially improve mouse and human HSC engraftment after transplantation. Chute and colleagues showed further that PTP-sigma regulates HSC function by suppressing a protein, RAC1, which is known to promote HSC engraftment after transplantation.    “These findings have tremendous therapeutic potential since we have identified a new receptor on HSCs, PTP-sigma, which can be specifically targeted as a means to potently increase the engraftment of transplanted HSCs in patients,” said Chute, senior author of the study and professor of hematology/oncology and...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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“When I was in graduate school, we didn’t even have a class on dysphagia,” I sometimes tell my students. But before you hold this against me, I did realize this gap in my education during my clinical fellowship back in 1993, so I attended a course taught by Jeri Logemann. The course helped me connect the dots, but I did my fellowship in an outpatient department for a children’s hospital, so I needed to learn quickly. Fortunately, Joan Arvedson, Bob Beecher and Monica Wojcik continued to shape my pediatric dysphagia knowledge. Now I’m a clinical instructor and guest lecturer teaching a pediatri...
Source: American Speech-Language-Hearing Association (ASHA) Press Releases - Category: Speech-Language Pathology Authors: Tags: Academia & Research Health Care Slider Speech-Language Pathology Dysphagia Feeding Disorders NICU Swallowing Disorders Source Type: blogs
Conclusion: Although miR-126 relevant role in several immune-related diseases, further studies are needed to clear its molecular mechanisms; the final step of these novel researches could be the blockage or the prevention of the diseases onset by creating of new targeted therapy. PMID: 29743819 [PubMed]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Clin Mol Allergy Source Type: research
CONCLUSIONS: QHT has proven to be a safe alternative for the treatment of intermediate and high risk NMIBC, with AE mainly grade 1-2. The AEs reported have little variation with respect to the dose of MMC used, presenting different "profiles" related to the device used for its administration. The treatments with QHTMMC are well tolerated, without adding significantly more AE than the instillations of MMC alone and presenting a better toxicity profile than those reflected in the literature with respect to the treatment with BCG. PMID: 29745932 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
Abstract CAPSULE SUMMARY: Our study demonstrates that miRNAs serve as critical epigenetic regulators in the ontogeny of LCs and TRMs in the skin and lungs, suggesting that miRNAs may be promising targets for LC and TRM-related allergic diseases. PMID: 29751006 [PubMed - as supplied by publisher]
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: J Allergy Clin Immunol Source Type: research
Allergy, EarlyView.
Source: Allergy - Category: Allergy & Immunology Authors: Source Type: research
Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE- λ was made for future studies in dogs as translational model patients.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Abstract Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE-λ was made for future studies in dogs as translational model patients. PMID: 29746883 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: J Allergy Clin Immunol Source Type: research
Background: Exercise-associated muscle cramping (EAMC) is a significant medical complication in distance runners, yet factors associated with EAMC are poorly documented. Objective: To document risk factors associated with EAMC in runners. Design: Cross-sectional study. Setting: Two ocean races (21.1 km, and 56 km). Participants: Fifteen thousand seven hundred seventy-eight race entrants. Methods: Participants completed a prerace medical history screening tool including: training, cardiovascular disease (CVD), risk factors for, and symptoms of CVD, history of diseases affecting major organ systems, cancer, ...
Source: Clinical Journal of Sport Medicine - Category: Sports Medicine Tags: Original Research Source Type: research
For those individuals interested in basic and translational immunology, then the book Immunology edited by M.A. Hayat is one to obtain for your library. This book touches on many aspects of immunology that most allergists and clinical immunologists do not readily encounter in the care of their patients. This volume is to be the first of many to be published that discuss different aspects of immunology. Volume 1 focuses on better understanding immune responses pertaining to infection and cancer immunology, which together account for the sixth leading cause of death in the United States and cost our health care system billio...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Book Review Source Type: research
Discussion Flushing is usually thought of as a benign condition such as blushing, but can be quite irritating if it is frequent or persistent (i.e. menopausal hot flashes) or even pathologic (i.e. malignancy). “Flushing is a subjective and sensation of warmth that is accompanied by reddening of the skin anywhere on the body but favors the face, neck, and upper torso…. Flushing can be broadly divided into episodic or persistent. Episodic flashing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing result in a fixed facial erythema with telangiectasias and cyan...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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