The world pandemic of Vitamin D deficit could possibly be explained by cellular inflammatory response activity induced by the renin angiotensin system.

The world pandemic of Vitamin D deficit could possibly be explained by cellular inflammatory response activity induced by the renin angiotensin system. Am J Physiol Cell Physiol. 2013 Jan 30; Authors: Ferder M, Inserra F, Manucha W, Ferder L Abstract This review attempts to show that there may be a relationship between inflammatory processes induced by chronic overstimulation of the renin angiotensin system (RAS) and the worldwide vitamin D (VitD) deficiency, and probably both disorders are associated with environmental factors. Low VitD levels represent a risk factor for several apparently different diseases such as infectious, autoimmune, neurodegenerative, and cardiovascular diseases, as well as diabetes, osteoporosis, and cancer. Moreover, VitD insufficiency seems to predispose hypertension, metabolic syndrome, left ventricular hypertrophy, heart failure, and chronic vascular inflammation. On the other hand, the inappropriate stimulation of the RAS has been associated with the pathogenesis of hypertension, heart attack, stroke, and hypertrophy of both the left ventricle and vascular smooth muscle cells. A possible link between VitD and the RAS is even more plausible when taking into account that VitD (VDR) and RAS receptors are distributed in almost the same tissues. From an evolutionary point of view, both systems were developed simultaneously, having an active participation in the regulation of inflammatory and immunological mechanisms. ...
Source: American Journal of Physiology. Cell Physiology - Category: Cytology Authors: Tags: Am J Physiol Cell Physiol Source Type: research