FDA Scrambles to Prevent Shortages Amid Sterilization Shutdowns
Shutdowns of two facilities that use ethylene oxideÂ to sterilize medical devices have raisedÂ concern about potential shortages in the medtech industry because this is such a popular sterilization method for medical devices. Ethylene oxide (EtO) is a flammable, colorless gas used to make a range of products. EtO also is used to sterilize equipment and plastic devices that cannot be sterilized by steam, such as medical equipment. In fact, about half of allÂ sterilized medical devices undergo sterilization using this gas. According to the EPA, long-term exposure to EtO can irritate the eyes, skin, nose, throat, and lungs, and harm the brain and nervous system (causing headaches, memory loss, and numbness). Studies show that breathing air containing elevated EtO levels over many years increases the risk of some types of cancers, including cancers of the white blood cells (such as non-Hodgkin's lymphoma, myeloma, and lymphomatic leukemia). It also has been found to cause breast cancer in women. Sterilization of medical devices is critical to the healthcare system, and ethylene oxide sterilization helps ensure the safety of medical devices and helps deliver quality patient care, according to outgoing FDA Commissioner Scott Gottlieb. Devices sterilized with EtO range from wound dressings to stents, as well as kits used in routine hospital procedures or surgeries that include multiple components made of different materials, the commissioner noted. &...
(Wiley) Survivors of childhood brain tumors who received radiotherapy and were very young at the time of diagnosis may experience cognitive and socioeconomic burdens decades after treatment, according to a study published early online in CANCER, a peer-reviewed journal of the American Cancer Society. Interventions such as cognitive therapies and educational and occupational services may be needed to mitigate such long-term effects.
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0495-5The role of mouse tumour models in the discovery and development of anticancer drugs
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0500-zObesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians
British Journal of Cancer, Published online: 24 June 2019; doi:10.1038/s41416-019-0504-8RRx-001 followed by platinum plus etoposide in patients with previously treated small-cell lung cancer
ConclusionOCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.
Conclusions: p65BTK is frequently expressed in CRC and, if highly expressed, is an unfavourable prognostic factor. However, further confirmation is needed and its potential targeting needs to be studied.
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