Phytochemistry and biological activities of Polemonium caeruleum L.

Publication date: Available online 20 February 2019Source: Phytochemistry LettersAuthor(s): Grażyna Łaska, Elwira Sieniawska, Łukasz Świątek, Jordan Zjawiony, Shabana Khan, Anastazja Boguszewska, Marcin Stocki, Mirosław Angielczyk, Małgorzata Polz-DacewiczAbstractPolemonium caeruleum L. is a Chinese medicinal plant used in the treatment of tuberculosis, whooping cough, fever, infertility, epilepsy, endometritis and insomnia. It was also used as sedative and anaesthetic agent. In this work the phytochemical investigation using LC-ESI-QTOF-MS and GC–MS techniques was done for chemical characterization of methanol extracts of underground and aerial plant parts. In the course of our studies on medicinal plants, we evaluated the extracts of P. caeruleum for their biological activities as antimicrobial, antimalarial, anti-leishmanial and antitrypanosomal agents and we investigated their cytotoxicity towards mammalian cells – HEK293 and Vero cell lines, both originating from kidney and also against pharyngeal squamous cell carcinoma, FaDu cell line. LC-ESI-QTOF-MS analysis confirmed the presence of triterpene saponins – oleanane derivatives (polemoniumsaponins, glycosides of theasapogenol derivatives and β-amyrin among others), as well as flavonoid glycosides with most predominant acacetin derivatives. Saponins were more abundant and varied in the extract from underground parts of the plant, while flavonoids dominated in the extract from aerial parts. G...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research

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Daniel J. IkensonSome people talk about trade as though it were an end in itself. It ’s not. Trade is a means to an end.We trade so that we can specialize. We specialize so that we can produce more. We produce more so that we can consume and save more. That is how we create wealth and raise living standards. Just like electricity or machinery or expertise, trade is a tool we use to leverage our physical, mental, and creative abilities to obtain more efficiently more of the things we need and want. When we remove barriers to trade, we create greater scope for specialization, which means we can produce more v...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Authors: Ventura CG, Roque FL, Sousa IQ, Lobo RD, Luders C Abstract INTRODUCTION: Chronic hemodialysis (HD) patients are considered to be at high risk for infection. Here, we describe the clinical outcomes of chronic HD patients with influenza A (H1N1) infection and the strategies adopted to control an outbreak of influenza A in a dialysis unit. METHODS: Among a total of 62 chronic HD patients, H1N1 infection was identified in 12 (19.4%). Of the 32 staff members, four (12.5%) were found to be infected with the H1N1 virus. Outcomes included symptoms at presentation, comorbidities, occurrence of hypoxemia, hospit...
Source: Jornal Brasileiro de Nefrologia - Category: Urology & Nephrology Tags: J Bras Nefrol Source Type: research
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Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: Available online 1 April 2020Source: Food ControlAuthor(s): Marie Frétin, Christophe Chassard, Céline Delbès, René Lavigne, Etienne Rifa, Sébastien Theil, Benoit Fernandez, Patrice Laforce, Cécile Callon
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Authors: Jordan V PMID: 32223856 [PubMed - in process]
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
Authors: Chuh A, Zawar V, Fölster-Holst R, Sciallis G, Rosemann T Abstract Dermoscopy in primary care enhances clinical diagnoses and allows for risk stratifications. We have compiled 25 recommendations from our experience of dermoscopy in a wide range of clinical settings. The aim of this study is to enhance the application of dermoscopy by primary care clinicians. For primary care physicians commencing dermoscopy, we recommend understanding the aims of dermoscopy, having adequate training, purchasing dermoscopes with polarised and unpolarised views, performing regular maintenance on the equipment, seeking co...
Source: Journal of Primary Health Care - Category: Primary Care Tags: J Prim Health Care Source Type: research
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Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
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Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
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