Early Detection and Molecular Characterization of Therapy-Related Leukemia in Children Reveals Patterns of Disease Transformation and Guides Future Surveillance Protocols

ConclusionsOur preliminary data demonstrate that NB patients at risk of developing secondary leukemia can be identified by molecular profiling of BM aspirates obtained during routine disease surveillance for NB. These findings present an opportunity for the development of early detection studies for patients with pediatric malignancies undergoing intensive therapy and importantly inform studies into mechanisms of leukemic transformation and specific gene-treatment effects.DisclosuresCheung: Ymabs: Patents & Royalties.

Source: Blood - November 21, 2018 Category: Hematology Authors: Spitzer, B., Gundem, G., Farnoud, N., Millard, N., McGovern, E., Patel, M., Levine, M., Medina, J., Zhou, Y., Arango Ossa, J. E., Walsh, M. F., Levine, R. L., Cheung, I. Y., Armstrong, S. A., Cheung, N.-K. V., Papaemmanuil, E. Tags: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis II Source Type: research