Myelodysplasia, Leukemia, Lymphoid Malignancies, and Other Cancers in Patients with Severe Chronic Neutropenia

Conclusions: The hematological consequences of severe chronic neutropenia depend on the underlying etiology. MDS and AML occur largely in patients with the congenital or hereditary neutropenias. The diagnosis of cyclic neutropenia and chronic idiopathic / autoimmune neutropenia portends a favorable prognosis, based on a total of 10482 person years of observation. Marrow failure and aplastic anemia are not expected consequences of severe chronic neutropenia.DisclosuresDale: Athelas, Inc.: Equity Ownership; Amgen: Consultancy, Research Funding; Sanofi-Aventi: Consultancy, Honoraria; Cellerant: Other: Scientific Advisory Board; Hospira: Consultancy; Prolong: Consultancy; Beheringer-Ingelheim: Consultancy; Coherus: Consultancy. Newburger: X4 Pharmaceutics: Consultancy, Honoraria; TransCytos LLC: Consultancy; Janssen Research & Development, LLC: Consultancy, Honoraria.

Source: Blood - November 21, 2018 Category: Hematology Authors: Dale, D. C., Bolyard, A. A., Alter, B. P., Bonilla, M. A., Connelly, J., Link, D. C., Newburger, P. E., Rosenberg, P. S., Shimamura, A., Walkovich, K. J. Tags: 201. Granulocytes, Monocytes, and Macrophages: Regulation of Myelopoiesis and Neutrophil Lineage Mutations: Biological Mechanism and Clinical Implications Source Type: research