Bioelectronic Medicine: Targeting Inflammatory Disease with Electricity

We presented positive initial results in Crohn’s disease at the 2016 United European Gastroenterology meeting: six of the eight patients had seen a substantial reduction in their disease activity index scores, and three were in remission from the disease. As SetPoint looks ahead, several chronic disease areas are emerging as key bioelectronic medicine therapy targets, and our company is exploring a number of these. One of our preclinical programs explores bioelectronic medicine’s potential role as a treatment for MS.   New Target: Multiple Sclerosis In late 2017, SetPoint presented positive data from a study exploring the therapeutic effects of a bioelectronic medicine approach for MS at the European Committee and Americas Committee for Research and Treatment in Multiple Sclerosis (ECTRIMS-ACTRIMS). Data showed that SetPoint’s therapy reduced demyelination and, more importantly, accelerated remyelination, which is a significant challenge in treating MS with currently available drugs/biologics. The study also demonstrated this approach reduced leakage of the blood-spinal cord barrier, which can prevent immune cell infiltration and further reduce disease progression. Current approved treatments for MS target the overactive immune response but do not repair damage to the myelin sheath – a critical aspect. These results show promise for a possible bioelectronic treatment for MS and lay the groundwork for further studies.   Bioelectronic Medici...
Source: Mass Device - Category: Medical Devices Authors: Tags: Bioelectronic Medicine Clinical Trials Neuromodulation/Neurostimulation SetPoint Medical Sponsored Content Source Type: news

Related Links:

ConclusionsFor both biologic-naïve and experienced PsA patients, secukinumab is either a dominant or cost-effective treatment option compared with other biologics in Argentina.
Source: Value in Health Regional Issues - Category: International Medicine & Public Health Source Type: research
Publication date: June 2019Source: American Journal of Preventive Medicine, Volume 56, Issue 6Author(s): Vincent J. Felitti, Robert F. Anda, Dale Nordenberg, David F. Williamson, Alison M. Spitz, Valerie Edwards, Mary P. Koss, James S. MarksBackgroundThe relationship of health risk behavior and disease in adulthood to the breadth of exposure to childhood emotional, physical, or sexual abuse, and household dysfunction during childhood has not previously been described.MethodsA questionnaire about adverse childhood experiences was mailed to 13,494 adults who had completed a standardized medical evaluation at a large HMO; 9,5...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
ConclusionHernia surgery, although an everyday event for many practitioners, requires the same rigor as all other visceral surgery.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
Publication date: Available online 17 May 2019Source: Cirugía Española (English Edition)Author(s): Irene Mirón Fernández, Cristina Rodríguez Silva, José Rivas Becerra, Julio Santoyo Santoyo
Source: Cirugia Espanola - Category: Surgery Source Type: research
AbstractCrohn ’s disease is an incurable inflammatory disorder that can affect the entire gastrointestinal tract. While medical management is considered first-line treatment, approximately 70–90% of patients with Crohn’s disease will require at least one surgical intervention during the course of their life times. Traditionally, abdominal surgery for Crohn’s disease has been performed via an open approach with an increasing adoption of minimally invasive techniques. The aim of this study was to evaluate and compare postoperative outcomes from an initial national experience with robotic-assisted ileo...
Source: Journal of Robotic Surgery - Category: Surgery Source Type: research
Source: MRC Funding Opportunities - Category: Research Source Type: funding
Abstract DNA double-stranded break (DSB) is one of the most catastrophic damages of genotoxic insult. Inappropriate repair of DNA DSBs results in the loss of genetic information, mutation, and the generation of harmful genomic rearrangements, which predisposes an organism to immunodeficiency, neurological damage, and cancer. The tumor repressor p53 plays a key role in DNA damage response, and has been found to be mutated in 50% of human cancer. p53, p63, and p73 are three members of the p53 gene family. Recent discoveries have shown that human p53 gene encodes at least 12 isoforms. Different p53 members and isofor...
Source: J Zhejiang Univ Sci ... - Category: Science Authors: Tags: J Zhejiang Univ Sci B Source Type: research
We examined if childhood abuse was associated with heightened risk of incident systemic lupus erythematosus (SLE). METHODS: Data were from the Nurses' Health Study II, a cohort of U.S. female nurses enrolled in 1989, followed with biennial questionnaires. We measured childhood physical and emotional abuse with the Physical and Emotional Abuse Subscale of the Childhood Trauma Questionnaire and sexual abuse with the Sexual Maltreatment Scale of the Parent-Child Conflict Tactics Scale, both administered in 2001. We identified incident SLE (>4 American College of Rheumatology 1997 classification criteria) through 2015. ...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Authors: Girolimetto N, Macchioni P, Tinazzi I, Costa L, McGonagle D, Peluso R, Del Puente A, Addimanda O, Marchetta A, Possemato N, Tasso M, Salvarani C, Scarpa R, Caso F Abstract OBJECTIVE: To use ultrasonography to explore whether the duration of psoriatic dactylitis was associated with different patterns of extracapsular and synovial based involvement. METHODS: One hundred cases of hand dactylitis from 85 psoriatic arthritis (PsA) patients were consecutively enrolled in a multicentre cross-sectional study and divided into two groups according to dactylitis duration (shorter or longer than the median: 20 wee...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Authors: Agca R, Hopman LHGA, Laan KCJ, van Halm VP, Peters MJL, Smulders YM, Dekker JM, Nijpels G, Stehouwer CDA, Voskuyl AE, Boers M, Lems WF, Nurmohamed MT Abstract OBJECTIVE: Cardiovascular (CV) disease risk is increased in rheumatoid arthritis (RA). However, longterm follow-up studies investigating this risk are scarce. METHODS: CARRÉ is a prospective cohort study investigating CV disease and its risk factors in 353 patients with longstanding RA. CV endpoints were assessed at baseline, 3, 10 and 15 years after the start of the study and are compared to a reference cohort(n=2540) including a large nu...
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
More News: Academia | Academies | Allergy & Immunology | Arthritis | Asthma | Autoimmune Disease | Brain | Cardiology | Cardiovascular | Clinical Trials | Crohn's Disease | Diabetes | Endocrinology | Gastroenterology | Gastroschisis Repair | Heart | Heart Disease | Medical Devices | Multiple Sclerosis | Neurology | Neuroscience | Peripheral Vascular Disease (PVD) | Rheumatoid Arthritis | Rheumatology | Stroke | Study