Cancer treatment response may be affected by gut bacteria
Conclusion This early-stage study gives us some insights into factors that might influence people's responses to a specific type of cancer treatment (immunotherapy with monoclonal antibodies). The findings are of interest, but don't have any immediate implications for cancer treatment. We don't know what the conditions that required antibiotic treatment were and whether these could have affected the response to immunotherapy. We don't know whether the antibiotics themselves influenced how well the immunotherapy worked, or whether it was their effect on gut bacteria. We also don't know whether having high levels of particular bacteria improves people's responses to immunotherapy, or whether the immunotherapy somehow influences the levels of specific bacteria. It's unclear whether the findings are more relevant to certain cancers or specific immunotherapies or antibiotic types, or if they're influenced by other patient characteristics. Further research first needs to clarify whether the gut bacteria directly influences people's responses to immunotherapy, and exactly how this happens. The next step would be to investigate whether treatment to change the gut bacteria could improve people's responses to cancer treatment. Overall, it's likely to be some time before we see whether this early study eventually leads to any changes in the way immunotherapy is given. These findings shouldn't cause any concern for people with cancer who need to take antibiotics. The risk of not ta...
STOMACH cancer symptoms include a poor appetite, weight loss, and nausea. Treatment can include operations as well as changes to what you eat. Adapting your diet to include more of these foods could help to treat the condition.
This report warns that reluctance to talk honestly about death is preventing people with cancer from dying'well'. It calls for Governments across the UK to honour their commitments to ensuring Advance Care Planning is used as an important part of a person-centred health service, so that people approaching the end of their lives receive the best care possible and their wishes for death and dying are fulfilled
AN artificial intelligence revolution to prevent 22,000 cancer deaths by 2033 was being unveiled today. Theresa May is challenging the NHS to transform healthcare.
The prognostic value of high sensitivity C-reactive protein in a multi-ethnic population after>10 years of follow-up: The Multi-Ethnic Study of Atherosclerosis (MESA). Int J Cardiol. 2018 Aug 01;264:158-164 Authors: Cainzos-Achirica M, Miedema MD, McEvoy JW, Cushman M, Dardari Z, Greenland P, Nasir K, Budoff MJ, Al-Mallah MH, Yeboah J, Blumenthal RS, Comin-Colet J, Blaha MJ Abstract BACKGROUND: The prognostic value of hsCRP in contemporary multi-ethnic populations is unclear, particularly in statin users. The aim of this study was to characterize the prognostic utility of hsCRP for atheroscleroti...
Abstract The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptas...
Abstract MicroRNAs (miRNAs) are poised to provide diagnostic, prognostic, and therapeutic targets for several diseases including malignancies for precision medicine applications. The miRNAs have immense potential in the clinical arena because they can be detected in the blood, serum, tissues (fresh and formalin-fixed paraffin-embedded), and fine-needle aspirate specimens. The most attractive feature of miRNA-based therapy is that a single miRNA could be useful for targeting multiple genes that are deregulated in cancers, which can be further investigated through systems biology and network analysis that may provid...
CONCLUSION: Since cardiac tamponade is generally not suspected as a cause of hemodynamic instability after a lung lobectomy, as it was in this case, a misdiagnosis of the patient's condition may have led to improper management resulting in death. As anesthesiologists are often involved in the initial resuscitation of morbid patients in Post-Anesthesia Care Units, their acquaintance with various postoperative complications and competence in echocardiography for assessing cardiac problems may contribute to patient survival. PMID: 29776668 [PubMed - as supplied by publisher]
CONCLUSIONS: Ring-shaped thread counter traction makes the most difficult duodenal ESD safer and easier without complications. PMID: 29764299 [PubMed - as supplied by publisher]
Novel concepts employing autologous, ex vivo expanded natural regulatory T cells (nTreg) for adoptive transfer has potential to prevent organ rejection after kidney transplantation. However, the impact of dialysis and maintenance immunosuppression on the nTreg phenotype and peripheral survival is not well understood, but essential when assessing patient eligibility. The current study investigates regulatory T-cells in dialysis and kidney transplanted patients and the feasibility of generating a clinically useful nTreg product from these patients.
A 69-year-old man was referred to our department because of renal masses of the left kidney. The patient was diagnosed with a bladder carcinoma 10 months before in the context of macroscopic hematuria. The cancer had a partial squamous and papillary differentiation and was staged as G3pT1B with the infiltration of the superficial part of the bottom of the chorion. The patient underwent a transurethral resection of the bladder and had a course of intravesical injections of Bacillus Calmette-Guerin (BCG).
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