Cancer treatment response may be affected by gut bacteria

Conclusion This early-stage study gives us some insights into factors that might influence people's responses to a specific type of cancer treatment (immunotherapy with monoclonal antibodies). The findings are of interest, but don't have any immediate implications for cancer treatment. We don't know what the conditions that required antibiotic treatment were and whether these could have affected the response to immunotherapy. We don't know whether the antibiotics themselves influenced how well the immunotherapy worked, or whether it was their effect on gut bacteria. We also don't know whether having high levels of particular bacteria improves people's responses to immunotherapy, or whether the immunotherapy somehow influences the levels of specific bacteria. It's unclear whether the findings are more relevant to certain cancers or specific immunotherapies or antibiotic types, or if they're influenced by other patient characteristics. Further research first needs to clarify whether the gut bacteria directly influences people's responses to immunotherapy, and exactly how this happens. The next step would be to investigate whether treatment to change the gut bacteria could improve people's responses to cancer treatment. Overall, it's likely to be some time before we see whether this early study eventually leads to any changes in the way immunotherapy is given. These findings shouldn't cause any concern for people with cancer who need to take antibiotics. The risk of not ta...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Source Type: news

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Publication date: Available online 13 December 2018Source: LWTAuthor(s): Hugues Guichard, Pascal Poupard, Laurie Legoahec, Mélanie Millet, Rémi Bauduin, Jean-Michel Le QuéréAbstractSixty-six French ciders were collected and characterized to build up a data base of eighty-eight variables, including sensory descriptors, aroma description and physicochemical variables. A classification in four main sensory categories was made on the basis of sensorial data. Fruity-Floral ciders were rich in acetate esters and low in volatile phenols, in opposition with phenol-like or off-flavour ciders having an in...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Authors: Karczewski J, Śledzińska E, Baturo A, Jończyk I, Maleszko A, Maleszko A, Samborski P, Begier-Krasińska B, Dobrowolska A Abstract The prevalence of obesity has recently increased dramatically and has contributed to the increasing prevalence of various pathological conditions, including type 2 diabetes mellitus, nonalcoholic fatty liver disease, asthma, various types of cancer, cardiovascular and neurodegenerative diseases, and others. Accumulating evidence points to localized inflammation in adipose tissue, which, in turn, promotes systemic low-grade inflammation as a primary force contributing to the d...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
Authors: Bastard JP, Fellahi S, Audureau É, Layese R, Roudot-Thoraval F, Cagnot C, Mahuas-Bourcier V, Sutton A, Ziol M, Capeau J, Nahon P Abstract An obesity-related altered adipose tissue secretion is suggested as a risk factor for hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) cirrhosis. However, no prospective study has yet examined the predictive value of circulating adipokines and immuno-inflammatory biomarkers regarding this risk. This was a case-control study nested in a prospective French national cohort of HCV-infected patients with biopsy-proven compensated cirrhosis. We se...
Source: European Cytokine Network - Category: Molecular Biology Tags: Eur Cytokine Netw Source Type: research
Publication date: 15 December 2018Source: New Scientist, Volume 240, Issue 3208Author(s):
Source: New Scientist - Category: Science Source Type: research
CONCLUSION: Bone pain is a common and sometimes severe symptom of bone metastases in advanced breast cancer and a common reason for initiating BTA treatment. Safety and efficacy were the main factors considered by physicians when selecting BTAs. Past Presentations: Data previously presented at the ISPOR 18th Annual European Congress, Milan, Italy; November 7-11, 2015 and at the Breast Cancer Symposium, San Francisco, CA, USA; September 25-27, 2015. PMID: 30550358 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSIONS: The data of this post-marketing study meet the request by the French authorities for additional data on conditions of use in everyday practice. They confirmed the tolerance and long-term effect of capsaicin 8% patch in patients with peripheral neuropathic pain in real-world conditions. PMID: 30550354 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
CONCLUSIONS: Although the use of PP-CSF is commonplace in current US clinical practice, underutilization in cancer patients receiving chemotherapy regimens with an intermediate/high-risk for FN may still be an issue. Use of same-day PP-CSF increased markedly from the end of 2015, although this finding reflects (at least in part) increased uptake of pegfilgrastim delivered via an on-body injector as well as the recent change in clinical practice guidelines. Overall, patients receiving PP-CSF appear to have a lower risk of FN during the first cycle of chemotherapy. PMID: 30550346 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Publication date: Available online 16 December 2018Source: European UrologyAuthor(s): Anwar R. Padhani, Masoom A. Haider, Arnauld Villers, Jelle O. Barentsz
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 December 2018Source: European UrologyAuthor(s): Yongbao Wei, Tao Li, Longfei Liu
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 December 2018Source: Annals of Physical and Rehabilitation MedicineAuthor(s): Zineb Benhissen, Michel Konzelmann, Philippe Vuistiner, Bertrand Leger, François Luthi, Charles BenaimAbstractObjective. To estimate the Minimal Clinically Important Difference (MCID) of the French version of the Hand Function Sort questionnaire (HFS-F). As a comparison, the MCID of the Disabilities of the Arm, Shoulder, and Hand (DASH) was also estimated.Materials and methods. We included French-speaking patients hospitalized in a multidisciplinary rehabilitation program for chronic pain of the upper ...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
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