Researchers may have discovered a cause of multiple sclerosis

Follow me on Twitter @RobShmerling Multiple sclerosis (MS) is a condition that causes damage to the substance that covers nerve cells. This interrupts normal communication between nerves, leading to problems with movement, speech, and other functions. We don’t know what causes MS but we think it is an autoimmune disease. What is an autoimmune disease? Autoimmune diseases develop when a person’s immune system goes after its own tissues and organs. Autoimmune disease can affect all parts of the body. For example: Type 1 diabetes. This is the type that usually affects kids and develops when abnormal antibodies attack certain cells in the pancreas, leaving it unable to produce enough insulin, so the body can’t regulate blood sugar properly Rheumatoid arthritis. Multiple joints and other organs become inflamed; the cause is unknown, but the presence of autoantibodies (antibodies directed against proteins in healthy tissues) and other abnormal immune function suggest it is an autoimmune disorder. Pernicious anemia. In this condition, anemia develops when the immune system produces antibodies that prevent absorption of vitamin B12 from food. And these are just a few. Autoimmune conditions are especially scary because the immune system goes rogue for no apparent reason. These are favorite conditions of medical television and movies, such as House, Grey’s Anatomy, and The Big Sick. What triggers autoimmune diseases? The most common explanation is that an affe...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Brain and cognitive health Injuries Neurological conditions Prevention Safety MS multiple sclerosis Source Type: blogs

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It’s been enough for a bit, isn’t it? For three months now, there has been little space in the world for any other kind of news. That is, news without the word ‘coronavirus’. But there was innovation, there is excitement and, well, even some weird (although useful!) inventions that appeared while the world has been in lockdown. So here’s an outlook on such news, all, promise, without that particular C-word. Hospitals have been facing great challenges recently. But they are on the verge of a new era that brings better care and more focus on the patient. This is a trend we have been talking a...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence Robotics Telemedicine & Smartphones Virtual Reality amazon diabetes smart contact lens Stanford University pharmacies Fitbit fitness trackers genome sequencing diabetes management genomic data 5G robot Source Type: blogs
Publication date: Available online 25 May 2020Source: Food HydrocolloidsAuthor(s): Chao Ai, Hecheng Meng, Jiawei Lin, Tao Zhang, Xiaoming Guo
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Progressive Familial Intrahepatic Cholestasis Type 2 (PFIC2) is a rare congenital cholestatic liver disease that progresses to end stage liver disease. It is associated with fat soluble vitamin D deficiency ri...
Source: International Journal of Pediatric Endocrinology - Category: Endocrinology Authors: Tags: Case report Source Type: research
The objective of the study was to establish the diagnostic accuracy of point-of-care devices for detecting anemia ...
Source: BMC Health Services Research - Category: General Medicine Authors: Tags: Research article Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
AbstractBackgroundThe aim of the study is to identify the effect of salt intake and diabetes itself on blood pressure (BP) profile and microalbuminuria in children with type one diabetes mellitus (T1DM). Our hypothesis is that higher amount of salt consumption and/or hyperglycemia may impair blood pressure pattern in children with T1DM.MethodsThis cross-sectional study included 84 children and adolescents with T1DM (62% females, age 13.9  ± 3.2 years, disease duration 7.3 ± 3.1 years, 43% poorly controlled diabetes) and 54 aged- and sex-matched healthy children with an ad...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionsThis prospective study suggests exposure to air pollution can trigger renal activity in cSLE patients.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
ConclusionWe conclude that POx has a limited validity as a primary endpoint for clinical studies in PH1 patients with stable kidney function. In addition, it does not correlate to SCr and eGFR in this group of patients.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
This study aimed to examine the association between ST, FFs, SSBs and depressive symptoms in Chinese adolescents, and explore the mediating effects of FFs and SSBs in the association between ST and depressive symptoms.MethodsThis school-based nationwide survey was carried out among 14,500 students in four provinces of China. The Children’s Depression Inventory was used to assess the participants’ depressive symptoms. ST, FFs and SSBs consumption was measured by a self-reported questionnaire. The Bayesian multiple mediation model was used to analyze the mediation effect.ResultsST, FFs and SSBs, were more likely ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
ConclusionThe PopPK/PD models showed numerically greater reductions in DAS28-CRP and ANC with sarilumab 200  mg every 2 weeks than with 150 mg every 2 weeks. There was no clinically meaningful influence of investigated covariates. These data contribute to the totality of evidence that supports a sarilumab subcutaneous starting dose of 200 mg every 2 weeks, with a subsequent reduction to 150 mg ever y 2 weeks in the event of laboratory abnormalities such as neutropenia.
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
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