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Abstract P4-22-21: NCI9782: A phase 1 study of talazoparib in combination with carboplatin and paclitaxel in patients with advanced solid tumors

Conclusion: PARP inhibition with talazoparib days 1-7 in combination with carboplatin and paclitaxel leads to DLT of myelosuppression. However, clinical responses are seen even with lower dose combinations.Citation Format: Turk A, Chan N, Leal T, O'Regan R, Tevaarwerk A, Rice L, Campbell T, Barroilhet L, Mehnert J, Eickhoff J, Kolesar J, Liu G, Wisinski K. NCI9782: A phase 1 study of talazoparib in combination with carboplatin and paclitaxel in patients with advanced solid tumors [abstract]. In: Proceedings of the Thirty-Ninth Annual CTRC-AACR San Antonio Breast Cancer Symposium; 2016 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2017;77(4 Suppl):Abstract nr P4-22-21.
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research

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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Authors: Ansari L, Jaafari MR, Bastami TR, Malaekeh-Nikouei B Abstract The development of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer drug in cancer tissue has attracted immense interest. In the present study, magnetic mesoporous silica nanoparticles (MMSNs) with magnetite core and silica shell were synthesized. The obtained MMSNs were characterized by DLS, XRD, FT-IR, TEM and VSM in order to investigate the nanoparticle characteristics. With the focus on in vivo validation of such magnetic drug delivery systems, we selected epirubicin (EPI) as the drug. The anticancer properti...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
In this study, a surface functionalized magnetic nanocomposite (NC) for codelivery of doxorubicin (DOX) and curcumin (CUR) is developed. NCs were coated with hydroxyapatite and were also cross linked with β-cyclodextrin. NCs efficiently encapsulated DOX and CUR. Release of CUR and DOX were in a sustained pH-depended pattern. β-cyclodextrin functionalization reduced protein corona according sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) analysis. As shown by flowcytometric and confocal microscopy analyses, NCs internalized efficiently by human breast carcinoma cells MCF-7 and adriamycin resis...
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
Miguel Delibes (1920 –2010) was one of the most important Spanish writers of the 20th century. In his novels, he used a distinctly clear and elegant language to convey the beauty of rural Castilla. He was a professor, journalist, and director of the newspaper El Norte de Castilla. He wrote 68 fiction books and was awa rded the most prominent Spanish literary prizes, including the Premio Nadal in 1947, the Prince of Asturias Award for Literature in 1982, and the Miguel de Cervantes Prize in 1993. His literary career was cut short in 1998, after he had surgery for colon cancer.
Source: Lancet Neurology - Category: Neurology Authors: Tags: In Context Source Type: research
Progressive multifocal leukoencephalopathy (PML), first described in 1959, is an often-fatal disease caused by an opportunistic infection by JC virus (JCV), which most human beings carry throughout life without consequences.1,2 PML was a major cause of death in patients with AIDS, but its prevalence decreased sharply with the introduction of retroviral therapy. PML is now mostly seen in patients during chemotherapy or immunosuppression. The first PML cases in patients with multiple sclerosis who were treated with natalizumab came as a surprise in 20053,4 because PML had not been observed with other drugs for multiple scler...
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Source: Medscape Pathology Headlines - Category: Pathology Tags: Hematology-Oncology News Source Type: news
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Source: European Thyroid Journal - Category: Endocrinology Source Type: research
CBS Local – People who drink more than the recommended daily limit of alcohol may harbor an unhealthy mix of bacteria in their mouths, a new study suggests. Researchers found that compared with nondrinkers, those who drank heavily had fewer “good” bacteria in their mouths. They were also hosting more “bad” bacteria — including bugs that have been linked to gum disease, heart disease, and cancer. The study is one of the latest to look at what factors influence the human “microbiome” – the trillions of bacteria and other microbes that naturally dwell in the...
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