Should Women Have Breast Implants Removed?

It was a story with a bit of irony, as well as ominous health warnings. Crystal Hefner, the 30-year-old wife of Playboy magazine mogul Hugh Hefner, announced in a story in People magazine last month that she'd had her breast implants removed because they were making her sick. Hefner posted a photo of her post-surgery self on Instagram with the caption, "Using 2016 to reclaim my health and embrace and love myself for the real me." The former model, now a DJ, was diagnosed a few months back with Lyme disease. Her symptoms included intolerance to foods and beverages as well as back, neck, and shoulder pain. Hefner also suffered from cognitive dysfunction (brain fog, memory loss), stunted hair growth, fatigue, burning bladder pain, low immunity, and recurring infections and problems with her thyroid and adrenals. People on social media pointed out that her symptoms matched those of something called breast implant illness. Is the illness real? Because of her celebrity, Hefner's procedure was well-publicized. There are also plenty of articles and blogs advising women to not get the implants or to have them removed. However, doctors in the plastic surgery field suggest the connection between her symptoms and Hefner's implants -- almost 10 years old -- may not be well-grounded. "There are millions of women worldwide who have had breast implants for either reconstructive or cosmetic reasons, and the purported adverse health impacts are rarely reported," D...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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In this study, we use ChIP-Seq to identify Dppa4 binding genome-wide in three distinct cell types: mouse embryonic stem cells (mESC), embryonal carcinoma cells, and 3T3 fibroblasts ectopically expressing Dppa4. We find a core set of Dppa4 binding sites shared across cell types, and also a substantial number of sites unique to each cell type. Across cell types Dppa4 shows a preference for binding to regions with active chromatin signatures, and can influence chromatin modifications at target genes. In 3T3 fibroblasts with enforced Dppa4 expression, Dppa4 represses the cell cycle inhibitor Cdkn2c and activates Ets family tra...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
ConclusionsThere was no evidence that neither short-term nor long-term exposure to meteorological parameters or air pollen counts were associated with self-reported peripartum depressive symptoms in Uppsala, Sweden.
Source: European Psychiatry - Category: Psychiatry Source Type: research
Conclusions: LUCAT1 was upregulated in ccRCC tissues and renal cancer cell lines, and significantly correlated with malignant stage and poor prognosis in ccRCC. LUCAT1 promoted proliferation and invasion in ccRCC cells through the AKT/GSK-3 β signaling pathway. We also revealed that LUCAT1 overexpression was induced by chemokine CXCL2. These findings indicate that the CXCL2/LUCAT1/AKT/GSK-3β axis is a potential therapeutic target and molecular biomarker for ccRCC.Cell Physiol Biochem 2018;48:891 –904
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusion: Our results have revealed a novel mechanism by which ALKBH5 inhibits pancreatic cancer motility by demethylating lncRNA KCNK15-AS1, identifying a potential therapeutic target for pancreatic cancer.Cell Physiol Biochem 2018;48:838 –846
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusion: Lower expression of miR-374a is associated with poor prognosis and miR-374a improves tumor biological behavior in bladder cancer cells, suggesting that miR-374a might be a novel small-molecule therapeutic target.Cell Physiol Biochem 2018;48:815 –826
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Conclusions: Our data revealbiological and functional interactions between immunotherapy and radiotherapy through the miR-195/-16 family regulatory cascade.Cell Physiol Biochem 2018;48:801 –814
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
In this study, we investigated the role of M1 and M2 AChR on passive avoidance learning and plasticity of synapses formed by Schaffer collaterals in freely moving rats. Experiments were performed using Wistar male rats. Seven days before testing, a recording electrode was lowered in the CA1 region under chloral hydrate anaesthesia to record the field excitatory postsynaptic potential (fEPSP) in response to Schaffer collateral stimulation. Selective M2 receptor antagonists methoctramine and selective M1 receptors antagonist pirenzepine were intraperitoneally injected immediately after training. The effects on memory retenti...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
Abstract The purpose of this review is to summarize current knowledge about the gut microbiota in neuropsychiatric disorders. It is estimated that the human gut is colonized by up to 1018 microorganisms, mostly anaerobic bacteria. The gut microbiome is responsible for multiple functions, e.g. tightness of the intestine barrier, digestion and absorption. The correlation between gut dysbiosis and development of psychiatric, autoimmune and allergic diseases as well as bidirectional communication between brain and gut microflora have been shown. Recent findings suggest that specific bacteria can be involved in the dev...
Source: Acta Neurobiologiae Experimentalis - Category: Neurology Authors: Tags: Acta Neurobiol Exp (Wars) Source Type: research
Publication date: November 2018Source: Clinica Chimica Acta, Volume 486Author(s): Jieli Li, Jing Ma, Elizabeth A. Wagar, Dong Liang, Qing H. MengAbstractBackgroundVoriconazole (VOR), an antifungal agent, is clinically monitored to guide therapeutic dosing and avoid toxicity. It is believed that measurement of serum unbound VOR provides more accurate information, especially in hypoalbuminemia patients. We developed and validated an accurate, simple and fast test with ultrafiltration and ultra-performance liquid chromatography (UPLC)-tandem mass spectrometry (MS/MS) to measure unbound VOR in human serum.MethodsThe Agilent UP...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
We present a modification of a partial sleeve left lower lobe resection in which we preserve the left upper bronchus artery by leaving the dorsal wall between the main and the left upper lobe bronchus intact thus maintaining a physiologic vascularization to the anastomosis.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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