Zika Interview: "Virus May Create Outbreaks In Europe, The U.S. And Asia In The Future"
Associated with grave birth defects, the Zika virus tearing across Latin America could eventually affect more than half of the world's population. That's according to the London School of Hygiene &Tropical Medicine which agreed to an interview via email. Although the current epidemic in the Americas is being spread by the Aedes aegypti mosquito, according to Jimmy Whitworth, the School's Professor of International Public Health: "A number of mosquitos have been documented to carry the Zika virus. For example, the Aedes albopictus mosquito which resides in large parts of the U.S., southern Europe, and Asia is of particular concern because it's a competent vector for the virus." It could therefore create large "outbreaks in the future." His thoughts are echoed by the Pan American Health Organization, which expects the disease to spread "everywhere the mosquito is." And, considering that Zika may have only arrived in Brazil 18 months ago via a single infected traveler who was bitten by a local mosquito, its capacity to spread at lighrening speed is quite alarming. It has since exploded across 23 countries in the Americas. "In the right conditions, with sufficient mosquitoes and closely packed humans, the virus can spread rapidly. Aedes aegypti, the main vector of Zika, is a domestic mosquito that can breed in any small deposit of water," says Martin Hibberd, Professor of Emerging Infectious Diseases at the School. Climate change m...
Publication date: Available online 23 January 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Richard R. Rustandi, Melissa HammAbstractCDTa, an actin ADP-ribosylation transferase, is a binary toxin produced by the bacterium Clostridium difficile which is commonly associated with the hypervirulent strain present in Clostridium difficile infections. The mutated form of CDTa, 4mCDTa, is one of the components in the tetravalent Clostridium difficile vaccine in which the residual toxicity of the ADP-ribosylation activity needs to be monitored for safety reasons. There are several ADP- ribosylation activi...
Publication date: Available online 22 January 2020Source: Revista Española de Cardiología (English Edition)Author(s): Ernesto Valero, Jessika González-D’Gregorio, Nieves Carbonell, Mónica García-Simón, José Ferreres, Juan Sanchis
In this study, we correlate single breath count (SBC) with arterial blood gas (ABG) parameters to derive a cutoff point for intubation and mechanical ventilation (MV) in Guillain-Barré Syndrome (GBS). Ninety-four GBS patients underwent serial SBC at 2 Hz using an audio program. ABG was done at admission, and repeated if SBC declined. The patients were intubated based on “the modified intubation criteria” as follows (a + b or c): (a) hypoxia (PaO2 50 mm of Hg); (c) acidosis (pH 20% had a negative predictive value of 88.5% (95% CI 77.0%–96.0%) and 80.8% (95% ...
CONCLUSIONS: Arabic-speaking women from Arab countries have higher risks of stillbirth compared with the French and English majority in Quebec. Strategies to reduce stillbirth risk among Arabic speakers should focus on improving identification of causes of death. PMID: 31968204 [PubMed - as supplied by publisher]
Contributors : E A Mesri ; J Naipauer ; M C AbbaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusKaposi's sarcoma (KS), is an AIDS-associated neoplasm caused by the KS herpesvirus (KSHV). A mouse model of KSHV-dependent tumorigenicity, allowed us to induce KSHV viral-episome loss following tumor development to test the plausibility of “hit and run” mechanism by KSHV. RNA-seq-transcriptome analysis and CpG-methylation were performed on KSHV positive cells, KSHV positive tumors and tumors that developed following viral-episome loss. During KSHV tumorigenesis, hypo-methylation...
New Advisory Committee on Immunization Practices recommendations allow more flexibility for use of either tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) or tetanus and diphtheria toxoids (Td) vaccines in three scenarios where only Td had been previously recommended, most notably for tetanus booster doses recommended every 10 years for all adults.
Pregnant women need to receive vaccines during pregnancy to keep themselves and their infants safe. Barriers to receiving vaccines, such as lack of insurance coverage, need to be removed so mothers and infants can be protected.
This report describes that birth defects potentially related to Zika virus infection during pregnancy increased fourfold in Puerto Rico and the U.S. Virgin Islands, areas with widespread local transmission of Zika virus during the study period.
This report says diagnoses of human immunodeficiency virus (HIV)-2 remain low in the United States, and the current HIV testing approach could be updated to streamline efficiencies.
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