Ensure a Sickness-Free Year With These 6 Habits
Credit One of the greatest blessings anyone can have is living a healthy life. But the abundance of sicknesses and diseases in the world today makes it almost a difficult task. The outbreak of both curable and incurable diseases which are all expensive to deal with is a real problem. But just like the saying goes, prevention is still better than cure. Our habits like they say will either make or mar us. These six habits below are inexpensive and will help you keep all those diseases at bay. 1. Fill up your Styrofoam cup with water more often than not To have a sickness free year, take less of alcohol and much more water. Doctors recommend a minimum of eight to ten glasses of water a day. Taking healthy amounts of water detoxifies the body. It also maintains normal bowel functions, prevents dehydration and exhaustion, enhances nutrients flow and keeps diseases at bay. 2. Love sweat, hate fat Whether it is going to the gym or just routine stretches early in the morning, any form of exercise does a lot of good to your body. The idea is not to build muscles, as muscles don't necessarily keep us healthy. Exercise and workouts however, helps prevent cardiovascular diseases as well as reduce body fat. They also help to increase stamina and energy levels. Exercising regularly is equally an effective way to maintain body weight and decrease tension. In fact, it has even been said to increase memory and clarity of thinking. You don't necessarily need to work your triceps so hard at t...
In conclusion, our results indicate that LRP1 promotes the dedifferentiation of PASMC from a contractile to a synthetic phenotype thus suggesting its contribution to vascular remodeling in PH.
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
This study demonstrates that CCL2 is a key molecule for the development of metabolic and histological alterations in the liver of mice sensitive to the development of hyperlipidemia and hepatic steatosis, a finding with potential to identify new therapeutic targets in liver diseases.
Publication date: Available online 21 March 2019Source: Redox BiologyAuthor(s): Tsung-Ming Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong LinAbstractLeft ventricular hypertrophy (LVH) in hypertension has prognostic significance on cardiovascular mortality and morbidity. Recently, we have shown that n-butylidenephthalide (BP) improves human adipose-derived stem cell (hADSC) engraftment via attenuated reactive oxygen species (ROS) production. This prompted us to investigate whether remote transplantation of BP-pretreated hADSCs confers attenuated LVH at an est...
Publication date: Available online 22 March 2019Source: Pharmacology Biochemistry and BehaviorAuthor(s): Tania Molina-Jiménez, Martín Jiménez-Tlapa, Malinalli Brianza-Padilla, Rossana Citlali Zepeda, Marisela Hernández-González, Herlinda Bonilla-JaimeAbstractAdministering clomipramine during the early days of life induced several behavioral and neurochemical alterations in adult male rats, which resemble major depression disorder. The alterations affected sexual performance, which is considered a reward-seeking behavior regulated by the dopaminergic system. Given that estrogen receptors a...
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
ConclusionsO-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.General significanceThis study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Phys. Chem. Chem. Phys., 2019, Accepted Manuscript DOI: 10.1039/C9CP00752K, PaperPaulo C. D. Mendes, Rafael Costa-Amaral, Janaina F Gomes, Juarez L. F. Da Silva Experimentally, steric and inductive effects have been suggested as important factors on alcohol adsorption and reactivity on transition-metal (TM) surfaces, however, the atomistic understanding of the behavior of alcohols in... The content of this RSS Feed (c) The Royal Society of Chemistry
Faraday Discuss., 2019, Accepted Manuscript DOI: 10.1039/C8FD00223A, PaperYong Zhao, Kenneth T. Kongstad, Yueqiu Liu, he chenghua, Dan Staerk Medicinal plants have been widely used as (poly)pharmacological remedies and constitute a rich source for anti-diabetic drug discovery. In the present study, forty medicinal plant samples collected in China were... The content of this RSS Feed (c) The Royal Society of Chemistry
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC01534E, CommunicationNeha Thakur, Mukesh Kumar, Subhasis D. Adhikary, Debaprasad Mandal, Tharamani Chikka Nagaiah To address the issues allied with cardiovascular diseases and increased prevalence of hypertension, a novel electrochemical sensor was developed based on poly(ionic liquid) [PVIM] –cobalt polyoxometalate (Co5POM) supported on carbonaceous materials... The content of this RSS Feed (c) The Royal Society of Chemistry
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