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New Mesothelioma Clinical Trial Hopes to Improve Chemotherapy

This study is part of a broad development program that includes a number of additional planned studies." TRACON Pharmaceuticals develops novel targeted cancer therapies. Its TRC105 antibody is directed at renal cell carcinoma and hepatocellular carcinoma. This clinical trial with TRC102 is one of five nationally involving methoxyamine, but one of more than 200 trials for mesothelioma.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news

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People who undergo root canals may soon have a tiny but powerful ally that could prevent infection after treatment.Researchers at theUCLA School of Dentistry and theUCLA Henry Samueli School of Engineering and Applied Science found in a clinical trial that nanodiamonds protected disinfected root canals after the nerve and pulp were removed, thereby improving the likelihood of a full recovery. The findings are a milestone for the use of nanodiamonds in humans.Nanodiamonds are tiny particles made of carbon and are so small that millions of them could fit on the head of a pin. They resemble soccer balls but have facets like a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Abstract: The purpose of this study was to assess the effects of an in-hospital exercise intervention during neoadjuvant chemotherapy on the inflammatory profile and immune cell subpopulation in 20 children with solid tumors (control [n = 11] and exercise group [n = 9]). Although no significant interaction (group × time) effect was found with an analysis of variance test, we found a trend toward an interaction effect for natural killer cells expressing the immunoglobulin-like receptor KIR2DS4, with their numbers remaining stable in the exercise group but increasing in controls. Our data support that exercise interven...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Brief Reports Source Type: research
Participating in a yoga program while undergoing radiation therapy improved physical functioning and mental in NSCLC patients, and improved vitality in caregivers.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
By Kelly Young Edited by David G. Fairchild, MD, MPH, and Jaye Elizabeth Hefner, MD Scientists have identified new genetic variants related to breast cancer risk, nearly doubling the …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news
UAB Hospital has received a 2017 Women ’s Choice Award for being one of America’s Best Breast Centers in the United States. The designation was given to UAB based on clinical excellence and patient satisfaction.  “We take great pride in receiving this honor, especially since it comes from the women we have cared for,” said Dr . Helen Krontiras, director of the UAB Division of Surgical Oncology and medical director of the UAB Breast Health Center. “We now know that breast cancer is not…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
No abstract available
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Contributors: Ovarian Cancer and Prevention: PDF Only Source Type: research
No abstract available
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
Ovarian carcinomas were formerly referred to as “surface epithelial carcinomas,” reflecting the belief that they all arise from the ovarian surface epithelium. It is now appreciated that most ovarian carcinomas originate from either fallopian tube or endometriotic epithelium, and how we approach prevention will thus differ between histotypes. The 5 histotypes of ovarian carcinoma (high-grade serous, clear cell, endometrioid, mucinous, and low-grade serous, in descending order of frequency) can be reproducibly diagnosed, and are distinct disease entities, differing with respect to genetic risk factors, molecular...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
Detailed pathologic studies over the past decade suggest a distal fallopian tube origin for the majority of “ovarian” high-grade serous carcinomas (HGSC). This review will summarize molecular alterations observed in tubal precursors for HGSC, namely p53 signatures and serous tubal intraepithelial carcinomas, and in nonmalignant fallopian tube epithelial cells obtained from women at increased genetic risk for HGSC. Recent experiments investigating the impact of follicular fluid exposure and retrograde menstruation on tumor development in the fallopian tube will also be discussed. These data will be reconciled wi...
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
Endometriosis-associated cancers include clear cell and endometrioid ovarian carcinoma. A history of endometriosis has long been considered to be a risk factor for later development of these malignancies; however, recent molecular genetic evidence has provided unequivocal evidence that these lesions are in fact the precursors for endometriosis-associated cancers. Herein, we will explore the relationship between endometriosis and ovarian carcinomas, similarities between the premalignant lesions and their cancerous counterparts, and the potential role of mutations and the ovarian microenvironment that may contribute to malignant transformation.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Ovarian Cancer and Prevention Source Type: research
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