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New Mesothelioma Clinical Trial Hopes to Improve Chemotherapy

This study is part of a broad development program that includes a number of additional planned studies." TRACON Pharmaceuticals develops novel targeted cancer therapies. Its TRC105 antibody is directed at renal cell carcinoma and hepatocellular carcinoma. This clinical trial with TRC102 is one of five nationally involving methoxyamine, but one of more than 200 trials for mesothelioma.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news

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Authors: Yılmaz Susluer S, Kayabasi C, Ozmen Yelken B, Asik A, Celik D, Balci Okcanoglu T, Serin Senger S, Biray Avci C, Kose S, Gunduz C Abstract Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression of lncRNAs and disruption of the regulatory processes are recognized as critical steps in cancer development. The role of lncRNAs in hepatitis B virus (HBV) infection is not well understood. Here we analyzed the expression of 135 lncRNAs in plasm...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Abstract Objective: Fecal immunochemical tests (FITs) for hemoglobin in stool are increasingly used for colorectal cancer screening. Reported sensitivities and specificities have strongly varied between studies, but it is unclear to what extent such variation reflects differences between tests or between study population characteristics. We aimed to evaluate the key parameters of FIT performance for detecting advanced neoplasia (AN) according to sex and age. Methods: Sex- and age-specific sensitivity, specificity, positive predictive values (PPVs) and negative predictive values (NPVs) for detecting AN of a qu...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research
Open repair of ascending aortic pseudoaneurysms (AAPs) is currently the standard of care, but it is associated with high morbidity and mortality. A single-center retrospective experience of 4 patients after cardiac surgery undergoing 5 percutaneous transthoracic embolization procedures is presented. In 3 of the 4 patients, the primary outcome of complete thrombosis was achieved after the first procedure, with a mean follow-up time of 11.5 months. In all 5 procedures, the patients tolerated the procedure well without associated acute complications.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Brief Report Source Type: research
We appreciate your interest in our recent publication concerning the split-bolus single-phase contrast-enhanced cone-beam computed tomography (CT) protocol for hypervascularized liver tumors (1). The diagnosis of hepatocellular carcinoma was verified in all cases before intervention with magnetic resonance (MR) imaging using imaging features such as the typical contrast enhancement patterns, including the hepatobiliary phase with liver-specific contrast agent and tumor growth at follow-up (2). However, some tumors failed to show a sharp arterial hyperperfusion and washout in the portal venous or venous phase, although tumo...
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
With great interest, we read the article “Transcatheter Arterial Embolization for Gastrointestinal Bleeding Associated with Gastric Carcinoma: Prognostic Factors Predicting Successful Hemostasis and Survival” by Sangik Park et al (1). In their study, Park et al constructed a multivariate Cox model to identify predictors of successful transcatheter arterial embolization and 30-day survival after transcatheter arterial embolization.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
First of all, we express our deep appreciation for your taking the time to read our article and commenting on it.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
Type II endoleaks (ELIIs) occur in up to 10% of patients who undergo thoracic endovascular aortic repair (TEVAR) (1). Although after TEVAR, ELIIs are usually considered benign, they can be associated with high reintervention rates (1). Treatment of ELIIs can be challenging due to complex postsurgical anatomy and difficulty in visualization. Urgent treatment of ELIIs is indicated in patients with increasing aortic diameter and/or large endoleak cavities (1). This case is of a patient who had expansion of the false lumen (FL) of a chronic type 1 dissection secondary to ELII caused by retrograde flow from a left vertebral art...
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
This report presents 3 procedures with visceral “chimney stenting” in conjunction with an endovascular aneurysm sealing (EVAS) device, known as chEVAS, for treatment of type 1a endoleak. It includes the first published chEVAS in a patient with previous fenestrated endovascular aneurysm repair (FEVAR). Cases include an 80-year-old man 8 years after FEVAR for a juxtarenal abdominal aortic aneurysm (AAA); an 85-year-old woman 9 months after endovascular aneurysm repair (EVAR) for a ruptured infrarenal AAA; and an 84-year-old woman 3 months after EVAR for a symptomatic infrarenal AAA.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Brief Report Source Type: research
This report describes a technique that modifies off-the-shelf endografts to treat iatrogenic type A aortic dissection.
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Letter to the Editor Source Type: research
The purpose of the present study was to determine whether certain foot/ankle surgeries would benefit from the routine use of low-molecular-weight heparin (LMWH) as postoperative deep venous thrombosis prophylaxis. We conducted a formal cost-effectiveness analysis using a decision analytic tree to explore the healthcare costs and health outcomes associated with a scenario of no prophylaxis and a scenario of routine LMWH prophylaxis for 4 weeks. The 2 scenarios were compared for 5 procedures: (1) Achilles tendon repair (ATR), (2) total ankle arthroplasty (TAA), (3) hallux valgus surgery (HVS), (4) hindfoot arthrodesis (HA), ...
Source: Journal of Foot and Ankle Surgery - Category: Orthopaedics Authors: Source Type: research
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