New Mesothelioma Clinical Trial Hopes to Improve Chemotherapy

This study is part of a broad development program that includes a number of additional planned studies." TRACON Pharmaceuticals develops novel targeted cancer therapies. Its TRC105 antibody is directed at renal cell carcinoma and hepatocellular carcinoma. This clinical trial with TRC102 is one of five nationally involving methoxyamine, but one of more than 200 trials for mesothelioma.
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Research & Clinical Trials Source Type: news

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During the production of this paper, an error appeared in the title. The title should be, “Immune Checkpoint Inhibition Combined With Intracranial Stereotactic Radiation Therapy in Non-Small Cell Lung Cancer: Is There an Increasing Rate of Radionecrosis or Not? In Regards to Schapira et al, Huppeling et al and Colaco et al.”
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
Prostate cancer is the leading cause of cancer treatment –related years lived with disability for men worldwide.1 This has driven a disruptive change in management of favorable-risk prostate cancer such that nearly all National Comprehensive Cancer Network (NCCN) very low-risk patients are recommended conservative management rather than radical therapy. 2 Simultaneously, at the other end of the risk spectrum, treatment intensification with more potent systemic therapies has been the subject of recent trials for men with higher-risk disease (eg, NCT02772588).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
In the above referenced article, portions of the text and table reading “CALGB 80801” should have read “CALGB 80101,” to correctly reflect the referenced Fuchs CS et al. publication and CALGB study. The authors regret the error.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Tags: Erratum Source Type: research
The authors' letter and translational research work support the question posed in the review1,2: Are we at the tipping point for the era of real-time radiation therapy? The research by Dahele and Verbakel adds additional clinical evidence that real-time 3-dimensional image guided radiation therapy (3D IGRT) can be performed on standard-equipped cancer radiation therapy (RT) systems. Indeed, had it been published or known to us before we wrote the review, their clinical translation of markerless spine tracking3 would have been included as a fourth real-time 3D IGRT implementation on standard-equipped systems.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research
Multiple randomized studies have demonstrated that breast-conserving therapy (partial mastectomy plus whole breast radiation) can yield survival outcomes equivalent to those of mastectomy (1). However, newer population-based data suggest that breast cancer –specific survival and overall survival with breast-conserving therapy may actually be better than those with mastectomy (2-8). How is this possible? How can removal of the breast yield outcomes inferior to those of a therapy that leaves most of the breast intact and where in-breast failures are r eported to occur in approximately 5% to 10% of patients at 10 y...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
In the world of cancer care, Halstedian paradigms for radical surgery have evolved toward organ preservation strategies without compromising the probability of cure. As such, clinicians have increasingly turned their focus toward minimizing the stigmata of treatment, with patient-centered outcomes having greater influence on decision making. Today, patients are typically able to preserve much of their functional anatomy and cosmesis. For example, selected patients with head and neck cancers are routinely offered a strategy of larynx preservation with upfront radiation therapy and chemotherapy, reserving a more morbid total...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
Given the high-grade epidural spinal cord compression, we would recommend urgent surgical decompression (1). Separation surgery for metastatic renal cell carcinoma is challenging given its highly vascular nature. As such, provided that the patient is not acutely symptomatic from spinal cord compression or overt mechanical instability, we would perform preoperative embolization of the segmental arterial feeders to improve hemostasis and visualization of the neural elements during the operation. Surgery would include a right costotransverse approach to tumor resection with likely sacrifice of the right T7 and possibly T8 ner...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
A 66-year-old ex-smoker presented with metastatic renal cell cancer with lytic lesions in the left femur, T8, and a 1.5-cm lesion in the right lung. A biopsy from the femur confirmed clear cell renal cell cancer; the lung lesion could not be biopsied safely. The patient underwent a radical nephrectomy (pathologically staged as pT3a). He commenced sunitinib, which was stopped owing to severe hypertension, followed by everolimus, stopped after 8 cycles owing to muscle cramping. Repeat imaging demonstrated resolution of the lung nodule but progression in the left femur, T8, and new disease in the anterior right 10th rib and left humerus.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Publication date: Available online 12 December 2018Source: Social Science &MedicineAuthor(s): Amelia M. Jamison, Sandra Crouse Quinn, Vicki S. FreimuthAbstractVaccine confidence depends on trust in vaccines as products and trust in the system that produces them. In the US, this system consists of a complex network connecting pharmaceutical companies, government agencies, and the healthcare system. We explore narratives from White and African American adults describing their trust in these institutions, with a focus on influenza vaccine. Our data were collected between 2012 and 2014 as part of a mixed-methods investigat...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
The nervous system in general is not particularly regenerative, but peripheral nervous system tissue is more capable of repair than central nervous system tissue. Focusing on neurons that link these two parts of the nervous system, researchers here report on mechanisms involved in repair of nervous system cells, and propose that it might be possible to make central nervous system cells act more like peripheral nervous system cells in this regard. Whether or not this can be achieved safely is another question, however; this is very early stage work, too early to answer many questions about safety and plausibility. ...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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