Innovations in Science: China Changing the Face of Global Research

On December 10 when this year's Nobel Prize winners assemble in Stockholm for the annual award ceremony, there is one particular Laureate in the science categories whose award may very well signal the start of a trend. Youyou Tu, of the China Academy of Traditional Chinese Medicine, Beijing, is one of the co-winners of this year's Nobel Prize in medicine for her work in "discoveries concerning a novel therapy against Malaria". Born in Ningbo, Zhejiang, China in 1930, she has no postgraduate degree (it was not offered in China prior to 1979), has not had any overseas research or study experiences and is not a member of any Chinese national academies. Indeed she is the first winner of a Nobel science prize to have spent all her life and career in China. Tu's accomplishments are certainly laudable in themselves but more to the point is the symbolism of the emergence of Chinese research on the global stage and its impact on the research landscape in the years to come. According to Scopus data, China is a highly prolific source of research output. In the decade from 2004 to 2014 China's research output has grown more than 400 percent. By comparison, global output during the same period grew 70 percent and in the US, the output increased a little over 30 percent. China's position as a major player in the international economy is not new by any means. Many global companies have relocated their manufacturing operations there and the country sits on vast natural resources....
Source: Science - The Huffington Post - Category: Science Source Type: news

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Soft Matter, 2019, Accepted Manuscript DOI: 10.1039/C9SM00677J, PaperAnil Kumar Dasanna, Dmitry A. Fedosov, Gerhard Gompper, Ulrich Sebastian Schwarz Red blood cells in shear flow show a variety of different shapes due to the complex interplay between hydrodynamics and membrane elasticity. Malaria-infected red blood cells become generally adhesive and... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - Category: Chemistry Authors: Source Type: research
Publication date: September 2019Source: Biomedicine &Pharmacotherapy, Volume 117Author(s): Qingjun Pan, Zejian Liu, Shuzhen Liao, Lin Ye, Xing Lu, Xiaoqun Chen, Zhihang Li, Xinxin Li, Yong-Zhi Xu, Huafeng LiuAbstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by inflammation and abnormal production of autoantibody, but the mechanisms of the aberrant immune responses are currently unknown. Recently, growing evidence has suggested that infection plays a pivotal role in SLE. Here, we investigate the role of infectious agents (e.g., Epstein-Barr virus, parvovirus B19, human T-lymphotro...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
[Ghanaian Times] Waste management expert Zoomlion and a member of the Jospong Group of Companies in collaboration with the Government of Ghana through the Ministry of Health, Ghana Health Services and the Noguchi Memorial Centre have began an extensive training of key malaria control players across the country towards the implementation of a national malaria control programme, which focuses mainly on killing the larvae of mosquitos.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable investment and a new sustainable model of vaccine development involving close collaborations between public and private sectors.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Perspectives Source Type: research
Condition:   Malaria Intervention:   Biological: PfSPZ Vaccine Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting
Source: - Category: Research Source Type: clinical trials
[Ghanaian Times] A high level stakeholders meeting is underway to review Ghana's efforts at reducing the malaria burden under the new "high burden to high impact (HBHI)" approach.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
In Tanzania, malaria ranks number three among the top ten causes of deaths in all age groups, however little is known about the utilisation of emergency department by patients with complications of malaria. We...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
[Retinal manifestations of neuro-malaria or "malarial retinopathy" in Yaoundé]. J Fr Ophtalmol. 2019 Jun 12;: Authors: Koki G, Ngoulou W, Nomo AF, Nguefack S, Epee E, Bella AL Abstract AIM: Contribute to the improvement of diagnostic and prognostic approaches to treating children with neuro-malaria in Yaoundé. PATIENTS AND METHOD: A prospective and analytical study carried out in 2 hospitals of Yaoundé from October 2015 to March 2016. All patients aged 3 months to 15 years hospitalized for neuro-malaria in one of the 2 hospitals benefited from...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
In this study, we phenotypically characterized the expression of T cell inhibitory(PD-1, CTLA-4) and senescent markers (CD28(-), CD57) from children with symptomatic malaria, asymptomatic malaria and healthy controls using flow cytometry. We observed increased expression of T cell exhaustion and senescence markers in the symptomatic children compared to the asymptomatic and healthy controls. T cell senescence markers were more highly expressed on CD8 T cells than on CD4 T cells. Asymptomatically infected children had comparable levels of these markers with healthy controls except for CD8+ PD-1+ T cells whose levels were s...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsOur findings confirm that helminth polyparasitism and co-infection with major diseases is common in the tropics. A multitude of factors acting at various hierarchical levels, such as interspecies interactions at the within-host infra-parasite community level and environmental variables at the higher host community level, could explain the observed positive associations between pathogens; there remains a need to develop new frameworks which can consider these multilevel factors to better understand the processes structuring parasite communities to accomplish their control.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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