Request for Startups in the Rejuvenation Biotechnology Space, 2023 Edition

It is time once again for my once-yearly set of unsolicited thoughts on biotech startups that I'd like to see join those already working hard on the basis for human rejuvenation. The industry is growing rapidly, but patchily. Partial reprogramming has received enormous attention, as has the development of senolytics. Meanwhile, other important goals in rejuvenation research languish, or presently have only one or two companies involved in clinical translation of promising academic projects. Many plausible paths forward go undeveloped; there are just as many opportunities to make a real difference in the world as there were a decade ago. Cell Therapy for Thymus Regrowth The thymus atrophies with age, reducing the production of new T cells to a fraction of what it once was. The adaptive immune system declines as a result, becoming cluttered with dysfunctional, broken, and worn cells. One of the more promising approaches to regrowing the aged, atrophied thymus involves intravenous delivery of cells, either progenitor thymocytes or endothelial cells, that home to the thymus. Once there, they promote growth of active thymic tissue. This has been demonstrated in mice, but the groups involved have moved on to try to find small molecule approaches, so far with only very limited progress to show for it. So why not take this cell therapy approach and bring it to the clinic? Production of universal cells from lines engineered to avoid immune rejection is presently a going conc...
Source: Fight Aging! - Category: Research Authors: Tags: Investment Source Type: blogs