Counteracting TGM2 by a Fibroin peptide ameliorated Adriamycin-induced nephropathy via regulation of lipid metabolism through PANX1-PPAR α/PANK1 pathway
In this study, we identified a novel short peptide (named YR-7, primary sequence ‘YEVEDYR’) from the natural Fibroin protein, and demonstrated that it significantly alleviated pathological renal changes in ADR-induced nephropathy. PANX1 was identified as the most notably upregulated component by RNA-sequencing. (Source: Translational Research)
Source: Translational Research - May 9, 2024 Category: Research Authors: Shan-Shan Li, Qiao-Juan Liu, Jia-Xin Bao, Meng-ting Lu, Bing-Quan Deng, Wen-Wen Li, Chang-Chun Cao Source Type: research
Immune cell distribution and DNA methylation signatures differ between tumor and stroma enriched compartment in pancreatic ductal adenocarcinoma
This study aims to investigate immune cell infiltration and epigenetic profiles in tumor cell enriched ( “Tumor”) and stroma cell enriched (“Stroma”) regions within human PDAC tissue samples. By comparing those regions, we identified 25,410 differentially methylated positions (DMPs) distributed across 6,963 unique genes. (Source: Translational Research)
Source: Translational Research - May 9, 2024 Category: Research Authors: Erwin Tomasich, Jakob M ühlbacher, Katharina Wöran, Teresa Hatziioannou, Merima Herac, Markus Kleinberger, Julia Maria Berger, Lea Katharina Dibon, Luzia Berchtold, Gerwin Heller, Elisabeth Sophie Bergen, Andrea Macher-Beer, Gerald Prager, Martin Schind Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Masthead
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Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Editorial Advisory Board
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Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Author Guidelines
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Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Information for Readers
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Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Contents
(Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Source Type: research
Immune checkpoint activity exacerbate renal interstitial fibrosis progression by enhancing PD-L1 expression in renal tubular epithelial cells
Renal interstitial fibrosis (RIF) is often associated with inflammatory cell infiltration and no effective therapy. Programmed death cell-1 (PD-1) and its ligand PD-L1 were playing critical roles in T cell coinhibition and exhaustion, but the role in RIF is unclear. Here the data analyses of serum from 122 IgA nephrology (IgAN) patients showed that high level of soluble PD-1(sPD-1) was an independent risk factor for RIF and renal function progression. PD-L1 was also overexpressed in renal interstitial tissues from both IgAN patients with high level of sPD-1 and the unilateral ureteral obstruction (UUO) mouse. (Source: Translational Research)
Source: Translational Research - May 7, 2024 Category: Research Authors: Yuting Zhang, Xue Mi, Yunchao Zhang, Jipeng Li, Yunlong Qin, Peng He, Ya Zhao, Binxiao Su, Lijie He Source Type: research
Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis
Chronic kidney disease (CKD) is a serious health problem worldwide, which ultimately leads to end-stage renal disease (ESRD). Renal fibrosis is the common pathway and major pathological manifestation for various CKD proceeding to ESRD. However, the underlying mechanisms and effective therapies are still ambiguous. Early growth response 2 (EGR2) is reportedly involved in organ formation and cell differentiation. To determine the role of EGR2 in renal fibrosis, we respectively confirmed the increased expression of EGR2 in kidney specimens from both CKD patients and mice with location in proximal tubules. (Source: Translational Research)
Source: Translational Research - April 26, 2024 Category: Research Authors: Anni Song, Ruiwei Yan, Wei Xiong, Huiling Xiang, Jing Huang, Anni Jiang, Chun Zhang Source Type: research
Extra-nuclear tert counteracts oxidative stress and promotes progression in papillary thyroid carcinoma
The reactivation of TERT is associated with poor outcome in papillary thyroid cancer (PTC). Extra-telomeric functions of TERT were reported, with a protective role against oxidative stress (OS). The aim of the present study was to explore the extra-nuclear TERT localization in PTC and its role in cancer progression.TERT nuclear export under OS were analyzed in K1 PTC cell line. We investigated the role of different TERT localizations using specific TERT constructs that limit its localization to the nucleus or to the mitochondria. (Source: Translational Research)
Source: Translational Research - April 24, 2024 Category: Research Authors: Marina Muzza, Gabriele Pogliaghi, Carla Colombo, Elisa Stellaria Grassi, Erika Carbone, Sonia Palazzo, Francesco Frattini, Giacomo Gazzano, Luca Persani, Laura Fugazzola Source Type: research
Inhibition of Usp14 ameliorates renal ischemia-reperfusion injury by reducing Tfap2a stabilization and facilitating mitophagy
This study aimed to evaluate the impact of ubiquitin-specific peptidase 14 (Usp14), a deubiquitinase, in IR injury by influencing mitophagy. (Source: Translational Research)
Source: Translational Research - April 19, 2024 Category: Research Authors: Yang Li, Boqing Dong, Ying Wang, Huanjing Bi, Jing Zhang, Chenguang Ding, Chenge Wang, Xiaoming Ding, Wujun Xue Source Type: research
Retraction notice to “Transfer of microRNA-221 from mesenchymal stem cell-derived extracellular vesicles inhibits atherosclerotic plaque formation” [Transl. Res. 226 (2020) 83–95]
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). (Source: Translational Research)
Source: Translational Research - April 11, 2024 Category: Research Authors: Ziyuan Guo, Zhuo Zhao, Chuang Yang, Chunli Song Source Type: research
Targeting the Devil: Strategies Against Cancer-Associated Fibroblasts in Colorectal Cancer
Cancer-associated fibroblasts (CAFs), as significant constituents of the tumor microenvironment (TME), play a pivotal role in the progression of cancers, including colorectal cancer (CRC). In this comprehensive review, we presented the origin and activation mechanisms of CAFs in CRC, elaborating on how CAFs drive tumor advancement through their interactions with CRC cells, immune cells, vascular endothelial cells, and the extracellular matrix within the tumor microenvironment. We systematically outline the intricate web of interactions among CAFs, tumor cells, and other TME components, and based on this complex interplay, ...
Source: Translational Research - April 11, 2024 Category: Research Authors: Yuting Chen, Zhiyong Liang, Maode Lai Source Type: research
Exosomal Tenascin-C Primes Macrophage Pyroptosis Amplifying Aberrant Inflammation during Sepsis-Induced Acute Lung Injury
Sepsis-induced acute lung injury (ALI) is a serious complication of sepsis and the predominant cause of death. Exosomes released by lung tissue cells critically influence the progression of ALI during sepsis by modulating the inflammatory microenvironment. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbates ALI in septic infection remain undefined. Our study found increased levels of exosomal Tenascin-C (TNC) in the plasma of both patients and mice with ALI, showing a strong association with disease progression. (Source: Translational Research)
Source: Translational Research - April 9, 2024 Category: Research Authors: Ting Gong, Xuedi Zhang, Xiaolei Liu, Yinfeng Ye, Zhiyuan Tian, Shuang Yin, Min Zhang, Jing Tang, Youtan Liu Source Type: research
