Exosomal Tenascin-C Primes Macrophage Pyroptosis Amplifying Aberrant Inflammation during Sepsis-Induced Acute Lung Injury

Sepsis-induced acute lung injury (ALI) is a serious complication of sepsis and the predominant cause of death. Exosomes released by lung tissue cells critically influence the progression of ALI during sepsis by modulating the inflammatory microenvironment. However, the molecular mechanisms by which exosome-mediated intercellular signaling exacerbates ALI in septic infection remain undefined. Our study found increased levels of exosomal Tenascin-C (TNC) in the plasma of both patients and mice with ALI, showing a strong association with disease progression.

Source: Translational Research - April 9, 2024 Category: Research Authors: Ting Gong, Xuedi Zhang, Xiaolei Liu, Yinfeng Ye, Zhiyuan Tian, Shuang Yin, Min Zhang, Jing Tang, Youtan Liu Source Type: research