Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts
Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased... (Source: Respiratory Research)
Source: Respiratory Research - April 24, 2024 Category: Respiratory Medicine Authors: Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang and Guoying Yu Tags: Research Source Type: research
PI3K γδ inhibition suppresses key disease features in a rat model of asthma
Two isoforms of Phosphoinositide 3-kinase (PI3K), p110 γ and p110δ, are predominantly expressed in leukocytes and represent attractive therapeutic targets for the treatment of allergic asthma. The study aim was... (Source: Respiratory Research)
Source: Respiratory Research - April 23, 2024 Category: Respiratory Medicine Authors: James W. Pinkerton, Silvia Preite, Antonio Piras, Dimitrios Zervas, Thomais Markou, Mark S. Freeman, Tobias Hofving, Emil Ivarsson, Sara J. Bonvini, Wayne Brailsford, Linda Yrlid, Maria G. Belvisi and Mark A. Birrell Tags: Research Source Type: research
Bacterial interactome disturbance in chronic obstructive pulmonary disease clinical stability and exacerbations
Our understanding of airway dysbiosis in chronic obstructive pulmonary disease (COPD) remains incomplete, which may be improved by unraveling the complexity in microbial interactome. (Source: Respiratory Research)
Source: Respiratory Research - April 20, 2024 Category: Respiratory Medicine Authors: Wei Xiao, Yi-long Chen, Long-yi Du, Jiqiu Wu, Zhang Wang, Bing Mao, Fu-qiang Wen, Peter Gerard Gibson, Vanessa M. McDonald, Haopeng Yu and Juan-juan Fu Tags: Research Source Type: research
PPAR γ attenuates cellular senescence of alveolar macrophages in asthma-COPD overlap
Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) represents a complex condition characterized by shared clinical and pathophysiological features of asthma and COPD in older individuals. Howeve... (Source: Respiratory Research)
Source: Respiratory Research - April 20, 2024 Category: Respiratory Medicine Authors: Rongjun Wan, Prakhyath Srikaram, Shaobing Xie, Qiong Chen, Chengping Hu, Mei Wan, Yuanyuan Li and Peisong Gao Tags: Research Source Type: research
Multidrug-resistant pathogens and ventilator-associated pneumonia in critically ill COVID-19 and non-COVID-19 patients: a prospective observational monocentric comparative study
The COVID-19 pandemic has increased the incidence of ventilator-associated pneumonia (VAP) among critically ill patients. However, a comparison of VAP incidence in COVID-19 and non-COVID-19 cohorts, particular... (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Giorgia Montrucchio, Eleonora Balzani, Gabriele Sales, Anna Vaninetti, Francesca Grillo, Anna Chiara Trompeo, Marinella Zanierato, Vito Fanelli, Silvia Corcione, Francesco Giuseppe De Rosa, Antonio Curtoni, Cristina Costa and Luca Brazzi Tags: Research Source Type: research
Positive effect of deep diaphragmatic breathing training on gastroesophageal reflux-induced chronic cough: a clinical randomized controlled study
To explore the efficacy of deep diaphragmatic breathing training (DEP) in patients with gastroesophageal reflux-induced chronic cough (GERC). (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Shanshan Niu, Tongyangzi Zhang, Wanzhen Li, Siwan Wen, Lei Dong, Shengyuan Wang, Wenbo Shi, Cuiqin Shi, Yuqin Shen, Qianchun Huang, Yaling Tan, Xianghuai Xu and Li Yu Tags: Research Source Type: research
Potential application of mesenchymal stromal cells as a new therapeutic approach in acute respiratory distress syndrome and pulmonary fibrosis
While the COVID-19 outbreak and its complications are still under investigation, post-inflammatory pulmonary fibrosis (PF) has already been described as a long-term sequela of acute respiratory distress syndro... (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Giulia Gazzaniga, Marta Voltini, Alessandro Carletti, Elisa Lenta, Federica Meloni, Domenica Federica Briganti, Maria Antonietta Avanzini, Patrizia Comoli and Mirko Belliato Tags: Correspondence Source Type: research
Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions
Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopt... (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Yangli Liu, Fengjia Chen, Zhimin Zeng, Chengcheng Lei, Dubo Chen and Xiaoyu Zhang Tags: Research Source Type: research
The endothelium: gatekeeper to lung ischemia-reperfusion injury
The success of lung transplantation is limited by the high rate of primary graft dysfunction due to ischemia-reperfusion injury (IRI). Lung IRI is characterized by a robust inflammatory response, lung dysfunct... (Source: Respiratory Research)
Source: Respiratory Research - April 18, 2024 Category: Respiratory Medicine Authors: Huy Q. Ta, Maniselvan Kuppusamy, Swapnil K. Sonkusare, Mark E. Roeser and Victor E. Laubach Tags: Review Source Type: research
Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease
Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a uniq... (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2024 Category: Respiratory Medicine Authors: Jingyuan Gao, Yuqiong Yang, Xiaopeng Xiang, Huimin Zheng, Xinzhu Yi, Fengyan Wang, Zhenyu Liang, Dandan Chen, Weijuan Shi, Lingwei Wang, Di Wu, Shengchuan Feng, Qiaoyun Huang, Xueping Li, Wensheng Shu, Rongchang Chen & hellip; Tags: Research Source Type: research
Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis
Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, pr... (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2024 Category: Respiratory Medicine Authors: Raisa Kraaijvanger, Montse Janssen Bon ás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn and Coline H. M. van Moorsel Tags: Research Source Type: research
Feasibility and acceptability of remotely monitoring spirometry and pulse oximetry as part of interstitial lung disease clinical care: a single arm observational study
Remote monitoring of patient-recorded spirometry and pulse oximetry offers an alternative approach to traditional hospital-based monitoring of interstitial lung disease (ILD). Remote spirometry has been observ... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Sarah Barth, Colin Edwards, Gauri Saini, Yussef Haider, Nicholas Paul Williams, Will Storrar, Gisli Jenkins, Iain Stewart and Melissa Wickremasinghe Tags: Research Source Type: research
Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen
Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in pa... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Melissa A. Kovach, Ulrika K äck, Karlhans F Che, Bettina Brundin, Jon R. Konradsen and Anders Lindén Tags: Research Source Type: research
Effects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study
Balloon pulmonary angioplasty (BPA) improves the prognosis of chronic thromboembolic pulmonary hypertension (CTEPH). Right ventricle (RV) is an important predictor of prognosis in CTEPH patients. 2D-speckle tr... (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2024 Category: Respiratory Medicine Authors: Yaning Ma, Dichen Guo, Jianfeng Wang, Juanni Gong, Huimin Hu, Xinyuan Zhang, Yeqing Wang, Yuanhua Yang, Xiuzhang Lv and Yidan Li Tags: Comment Source Type: research
Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice
Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. ... (Source: Respiratory Research)
Source: Respiratory Research - April 13, 2024 Category: Respiratory Medicine Authors: Nok Him Fung, Quynh Anh Nguyen, Catherine Owczarek, Nick Wilson, Nadeem Elahee Doomun, David De Souza, Kylie Quinn, Stavros Selemidis, Jonathan McQualter, Ross Vlahos, Hao Wang and Steven Bozinovski Tags: Research Source Type: research
