CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid
Recent data from human studies and animal models have established roles for type II alveolar epithelial cell (AEC2) injury/apoptosis and monocyte/macrophage accumulation and activation in progressive lung fibr... (Source: Respiratory Research)
Source: Respiratory Research - December 14, 2023 Category: Respiratory Medicine Authors: Doyun Kwak, Patrick B. Bradley, Natalia Subbotina, Song Ling, Seagal Teitz-Tennenbaum, John J. Osterholzer, Thomas H. Sisson and Kevin K. Kim Tags: Research Source Type: research
Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension
Hypoxic pulmonary hypertension (HPH) is a common type of pulmonary hypertension and characterized by pulmonary vascular remodeling and constriction. A large number of studies have shown that pulmonary vascular... (Source: Respiratory Research)
Source: Respiratory Research - December 13, 2023 Category: Respiratory Medicine Authors: Lei Ma, Yanxia Wang, Xiaoqian Li, Zefang Wang, Bo Zhang, Ying Luo, Yousheng Wu, Zhichao Li and Wen Niu Tags: Research Source Type: research
Deep learning prediction of hospital readmissions for asthma and COPD
Severe asthma and COPD exacerbations requiring hospitalization are linked to increased disease morbidity and healthcare costs. We sought to identify Electronic Health Record (EHR) features of severe asthma and... (Source: Respiratory Research)
Source: Respiratory Research - December 13, 2023 Category: Respiratory Medicine Authors: Kevin Lopez, Huan Li, Zachary Lipkin-Moore, Shannon Kay, Haseena Rajeevan, J. Lucian Davis, F. Perry Wilson, Carolyn L. Rochester and Jose L. Gomez Tags: Research Source Type: research
Alpha-defensins inhibit ERK/STAT3 signaling during monocyte-macrophage differentiation and impede macrophage function
Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder associated with a 5 –tenfold decrease in lung levels of alpha-1-antitrypsin (AAT) and an increased risk for obstructive lung disease. α-defensins are ... (Source: Respiratory Research)
Source: Respiratory Research - December 11, 2023 Category: Respiratory Medicine Authors: Jungnam Lee, Naweed Mohammad, Yuanqing Lu, Regina Oshins, Alek Aranyos and Mark Brantly Tags: Research Source Type: research
An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signal... (Source: Respiratory Research)
Source: Respiratory Research - December 7, 2023 Category: Respiratory Medicine Authors: Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Ger Tags: Research Source Type: research
Clinical impact of pre-existing acute exacerbation in patients with interstitial lung disease who underwent lung transplantation
Acute exacerbation of interstitial lung disease (AE-ILD) significantly impacts prognosis, leading to high mortality rates. Although lung transplantation is a life-saving treatment for selected patients with IL... (Source: Respiratory Research)
Source: Respiratory Research - December 7, 2023 Category: Respiratory Medicine Authors: Hyeon Hwa Kim, Ho Cheol Kim, Tae Sun Shim, Jee Hwan Ahn, Jin Won Huh, Sang-Bum Hong, Geun Dong Lee, Dong Kwan Kim, Seung-Il Park and Sehoon Choi Tags: Research Source Type: research
PTK2-associated gene signature could predict the prognosis of IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with a poor prognosis. Current/available clinical prediction tools have limited sensitivity and accuracy when evaluating clinical out... (Source: Respiratory Research)
Source: Respiratory Research - December 6, 2023 Category: Respiratory Medicine Authors: Anlin Feng, Yesenia Moreno Caro, Colin Gardner, Garrett Grischo, Ying Liang, Praveen D. Wickremasinghe, Michaela Polmann, Mrinalini Kala, Timothy Marlowe, Stephen M. Black, Kenneth S. Knox and Ting Wang Tags: Research Source Type: research
Lower myostatin and higher MUC1 levels are associated with better response to mepolizumab and omalizumab in asthma: a protein –protein interaction analyses
Biomarkers are needed to inform the choice of biologic therapy in patients with asthma given the increasing number of biologics. We aimed to identify proteins associated with response to omalizumab and mepolizuma... (Source: Respiratory Research)
Source: Respiratory Research - December 6, 2023 Category: Respiratory Medicine Authors: Ayobami Akenroye, Tanawin Nopsopon, Laura Cho, Matthew Moll and Scott T. Weiss Tags: Research Source Type: research
Ambient atmospheric PM worsens mouse lung injury induced by influenza A virus through lysosomal dysfunction
Particulate matter (PM) air pollution poses a significant risk to respiratory health and is especially linked with various infectious respiratory diseases such as influenza. Our previous studies have shown tha... (Source: Respiratory Research)
Source: Respiratory Research - December 6, 2023 Category: Respiratory Medicine Authors: Shunwang Li, Xiangwu Ju, Qiang Liu, Yiwu Yan, Cong Zhang, Yuhao Qin, Xingyu Deng, Chang Li, Mingyao Tian, Yanli Zhang, Ningyi Jin and Chengyu Jiang Tags: Research Source Type: research
Characterization and inhibition of inflammasome responses in severe and non-severe asthma
Increased airway NLRP3 inflammasome-mediated IL-1 β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immun... (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2023 Category: Respiratory Medicine Authors: Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O ’Neill, Matthew A. Cooper, Elizabeth Tags: Research Source Type: research
CSE triggers ferroptosis via SIRT4-mediated GNPAT deacetylation in the pathogenesis of COPD
It is now understood that ferroptosis plays a significant role in the progression of chronic obstructive pulmonary disease (COPD) induced by cigarette smoke extract (CSE). However, the mechanisms underlying th... (Source: Respiratory Research)
Source: Respiratory Research - December 1, 2023 Category: Respiratory Medicine Authors: Congping Li, Fei Chen, Liangfen Lin, Jiwei Li, Yamei Zheng and Qingyun Chen Tags: Research Source Type: research
Prediction of the number of asthma patients using environmental factors based on deep learning algorithms
Air pollution, weather, pollen, and influenza are typical aggravating factors for asthma. Previous studies have identified risk factors using regression-based and ensemble models. However, studies that conside... (Source: Respiratory Research)
Source: Respiratory Research - December 1, 2023 Category: Respiratory Medicine Authors: Hyemin Hwang, Jae-Hyuk Jang, Eunyoung Lee, Hae-Sim Park and Jae Young Lee Tags: Research Source Type: research
Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening
Parametric response mapping (PRM) enables the evaluation of small airway disease (SAD) at the voxel level, but requires both inspiratory and expiratory chest CT scans. We hypothesize that deep learning PRM fro... (Source: Respiratory Research)
Source: Respiratory Research - November 28, 2023 Category: Respiratory Medicine Authors: Bin Chen, Ziyi Liu, Jinjuan Lu, Zhihao Li, Kaiming Kuang, Jiancheng Yang, Zengmao Wang, Yingli Sun, Bo Du, Lin Qi and Ming Li Tags: Research Source Type: research
METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway
The accumulation of myofibroblasts is the key pathological feature of pulmonary fibrosis (PF). Aberrant differentiation of lung-resident mesenchymal stem cells (LR-MSCs) has been identified as a critical sourc... (Source: Respiratory Research)
Source: Respiratory Research - November 28, 2023 Category: Respiratory Medicine Authors: Yi Lu, Zeyu Liu, Yunjiao Zhang, Xiuhua Wu, Wei Bian, Shan Shan, Danrong Yang and Tao Ren Tags: Research Source Type: research
In vitro co-culture studies and the crucial role of fibroblast-immune cell crosstalk in IPF pathogenesis
IPF is a fatal lung disease characterized by intensive remodeling of lung tissue leading to respiratory failure. The remodeling in IPF lungs is largely characterized by uncontrolled fibrosis. Fibroblasts and t... (Source: Respiratory Research)
Source: Respiratory Research - November 27, 2023 Category: Respiratory Medicine Authors: Fama Thiam, Sakshi Phogat, Filsan Ahmed Abokor and Emmanuel Twumasi Osei Tags: Review Source Type: research
