Animal models of acute exacerbation of pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive scarring interstitial lung disease with an unknown cause. Some patients may experience acute exacerbations (AE), which result in severe lung damage... (Source: Respiratory Research)
Source: Respiratory Research - November 25, 2023 Category: Respiratory Medicine Authors: Xu Ye, Mingrui Zhang, Huimin Gu, Mengying Liu, Yichao Zhao, Yanchen Shi, Shufei Wu, Cheng Jiang, Xiaoling Ye, Huihui Zhu, Qi Li, Xinmei Huang and Mengshu Cao Tags: Review Source Type: research
Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9
Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung disease, is a leading cause of morbidity and mortality worldwide. Prolonged cigarette smoking (CS) that causes irreversible airway remo... (Source: Respiratory Research)
Source: Respiratory Research - November 25, 2023 Category: Respiratory Medicine Authors: Wensi Zhu, Linxiao Han, Yuanyuan Wu, Lin Tong, Ludan He, Qin Wang, Yu Yan, Ting Pan, Jie Shen, Yuanlin Song, Yao Shen, Qiaoliang Zhu and Jian Zhou Tags: Research Source Type: research
Role of thioredoxin in chronic obstructive pulmonary disease (COPD): a promising future target
Thioredoxin (Trx) is a secretory protein that acts as an antioxidant, redox regulator, anti-allergic, and anti-inflammatory molecule. It has been used to treat dermatitis and inflammation of the digestive trac... (Source: Respiratory Research)
Source: Respiratory Research - November 24, 2023 Category: Respiratory Medicine Authors: Heena Kansal, Vishal Chopra, Kranti Garg and Siddharth Sharma Tags: Review Source Type: research
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe ... (Source: Respiratory Research)
Source: Respiratory Research - November 23, 2023 Category: Respiratory Medicine Authors: Pierre-Alexandre Gagnon, Martin Klein, John De Vos, Sabrina Biardel, Andr éanne Côté, Krystelle Godbout, Michel Laviolette, Catherine Laprise, Said Assou and Jamila Chakir Tags: Research Source Type: research
Risk of cardiovascular events after an exacerbation of chronic obstructive pulmonary disease: results from the EXACOS-CV cohort study using the PHARMO Data Network in the Netherlands
People living with chronic obstructive pulmonary disease (COPD) have an increased risk of experiencing cardiovascular (CV) events, particularly after an exacerbation. Such CV burden is not yet known for incide... (Source: Respiratory Research)
Source: Respiratory Research - November 21, 2023 Category: Respiratory Medicine Authors: Karin M. A. Swart, Brenda N. Baak, Louise Lemmens, Fernie J. A. Penning-van Beest, Camilla Bengtsson, Muriel Lobier, Fabian Hoti, Dina Vojinovic, Lindy van Burk, Kirsty Rhodes, Edeltraut Garbe, Ron M. C. Herings, Clementine Nordon and Sami O. Simons Tags: Research Source Type: research
The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study
Several observational studies have found that physical inactivity and sedentary time are associated with idiopathic pulmonary fibrosis (IPF) risk. However, the causality between them still requires further inv... (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2023 Category: Respiratory Medicine Authors: Wanyang Lei, Mei Yang, Ziyu Yuan, Runlin Feng, Xiao Kuang, Zhiqiang Liu, Zongqi Deng, Xianglin Hu and Wenlin Tai Tags: Research Source Type: research
Impact of sex differences on cardiac injury in critically ill patients with COVID-19
COVID-19 infections are associated with accrued inflammatory responses which may result in cardiac injury. Immune response to infection appears different between men and women, suggesting that COVID-19 patient... (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2023 Category: Respiratory Medicine Authors: Mathieu Jozwiak, Denis Doyen, Pierre Denormandie, Antoine Goury, Jonathan Marey, Fr édéric Pène, Alain Cariou, Jean-Paul Mira, Jean Dellamonica and Lee S. Nguyen Tags: Research Source Type: research
Spatially distinct molecular patterns of gene expression in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a heterogeneous disease that is pathologically characterized by areas of normal-appearing lung parenchyma, active fibrosis (transition zones including fibroblastic foci) ... (Source: Respiratory Research)
Source: Respiratory Research - November 17, 2023 Category: Respiratory Medicine Authors: Rachel Z. Blumhagen, Jonathan S. Kurche, Carlyne D. Cool, Avram D. Walts, David Heinz, Tasha E. Fingerlin, Ivana V. Yang and David A. Schwartz Tags: Research Source Type: research
Deficiency of S100A8/A9 attenuates pulmonary microvascular leakage in septic mice
We have reported a positive correlation between S100 calcium-binding protein (S100) A8/S100A9 and sepsis-induced lung damage before. However, limited knowledge exists concerning the biological role of S100A8/A... (Source: Respiratory Research)
Source: Respiratory Research - November 17, 2023 Category: Respiratory Medicine Authors: Jiang Yu, Boying Zhao, Qiangzhong Pi, Guoxiang Zhou, Zhe Cheng, Can Qu, Xiaowen Wang, Lingwen Kong, Suxin Luo, Dingyuan Du and Yongzheng Guo Tags: Research Source Type: research
Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model
Pulmonary arterial hypertension (PAH) is a progressive and devastating disease characterized by pulmonary vascular remodeling which is associated with the malignant phenotypes of pulmonary vascular cells. Rece... (Source: Respiratory Research)
Source: Respiratory Research - November 17, 2023 Category: Respiratory Medicine Authors: Congke Zhao, Xiangyang Le, Mengqi Li, Yuanbo Hu, Xiaohui Li, Zhuo Chen, Gaoyun Hu, Liqing Hu and Qianbin Li Tags: Research Source Type: research
Baseline characteristics from a 3-year longitudinal study to phenotype subjects with COPD: the FOOTPRINTS study
FOOTPRINTS ® is a prospective, longitudinal, 3-year study assessing the association between biomarkers of inflammation/lung tissue destruction and chronic obstructive pulmonary disease (COPD) severity and progress... (Source: Respiratory Research)
Source: Respiratory Research - November 17, 2023 Category: Respiratory Medicine Authors: James D. Crapo, Abhya Gupta, David A. Lynch, Alice M. Turner, Robert M. Mroz, Wim Janssens, Andrea Ludwig-Sengpiel, Harald Koegler, Anastasia Eleftheraki, Frank Risse and Claudia Diefenbach Tags: Research Source Type: research
Clinical nomogram assisting in discrimination of juvenile dermatomyositis-associated interstitial lung disease
To establish a prediction model using non-invasive clinical features for early discrimination of DM-ILD in clinical practice. (Source: Respiratory Research)
Source: Respiratory Research - November 16, 2023 Category: Respiratory Medicine Authors: Minfei Hu, Chencong Shen, Fei Zheng, Yun Zhou, Liping Teng, Rongjun Zheng, Bin Hu, Chaoying Wang, Meiping Lu and Xuefeng Xu Tags: Research Source Type: research
Leveraging transcriptomics to develop bronchopulmonary dysplasia endotypes: a concept paper
Bronchopulmonary dysplasia has multiple definitions that are currently based on phenotypic characteristics. Using an unsupervised machine learning approach, we created BPD subclasses (e.g., endotypes) by clust... (Source: Respiratory Research)
Source: Respiratory Research - November 15, 2023 Category: Respiratory Medicine Authors: Alvaro G. Moreira, Tanima Arora, Shreyas Arya, Caitlyn Winter, Charles T. Valadie and Przemko Kwinta Tags: Research Source Type: research
Metagenomics for the microbiological diagnosis of hospital-acquired pneumonia and ventilator-associated pneumonia (HAP/VAP) in intensive care unit (ICU): a proof-of-concept study
Hospital-acquired and ventilator-associated-pneumonia (HAP/VAP) are one of the most prevalent health-care associated infections in the intensive care unit (ICU). Culture-independent methods were therefore deve... (Source: Respiratory Research)
Source: Respiratory Research - November 15, 2023 Category: Respiratory Medicine Authors: Morgane Heitz, Albrice Levrat, Vladimir Lazarevic, Olivier Barraud, St éphane Bland, Emmanuelle Santiago-Allexant, Karen Louis, Jacques Schrenzel and Sébastien Hauser Tags: Research Source Type: research
Expression of PD-1/PD-L1 axis in mediastinal lymph nodes and lung tissue of human and experimental lung fibrosis indicates a potential therapeutic target for idiopathic pulmonary fibrosis
Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking. (Source: Respiratory Research)
Source: Respiratory Research - November 14, 2023 Category: Respiratory Medicine Authors: Theodoros Karampitsakos, Apostolos Galaris, Serafeim Chrysikos, Ourania Papaioannou, Ioannis Vamvakaris, Ilianna Barbayianni, Paraskevi Kanellopoulou, Sofia Grammenoudi, Nektarios Anagnostopoulos, Grigoris Stratakos, Matthaios Katsaras, Fotios Sampsonas, Tags: Research Source Type: research
