The clinical impact of Lumacaftor-Ivacaftor on structural lung disease and lung function in children aged 6 –11 with cystic fibrosis in a real-world setting
Data from clinical trials of lumacaftor-ivacaftor (LUM-IVA) demonstrate improvements in lung clearance index (LCI) but not in FEV1 in children with Cystic Fibrosis (CF) aged 6 –11 years and homozygous for the Phe5... (Source: Respiratory Research)
Source: Respiratory Research - August 11, 2023 Category: Respiratory Medicine Authors: Paul McNally, Barry Linnane, Michael Williamson, Basil Elnazir, Christopher Short, Clare Saunders, Laura Kirwan, Rea David, Mariette P. C. Kemner-Van de Corput, Harm A.W.M. Tiddens, Jane C Davies and Des W Cox Tags: Research Source Type: research
Retraction Note: Shp2 positively regulates cigarette smoke-induced epithelial mesenchymal transition by mediating MMP-9 production
(Source: Respiratory Research)
Source: Respiratory Research - August 11, 2023 Category: Respiratory Medicine Authors: Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie and Yicheng Xie Tags: Retraction Note Source Type: research
Molecular mechanisms and treatment responses of pulmonary fibrosis in severe COVID-19
Coronavirus disease 2019 (COVID-19) patients can develop pulmonary fibrosis (PF), which is associated with impaired outcome. We assessed specific leukocytic transcriptome profiles associated with PF and the in... (Source: Respiratory Research)
Source: Respiratory Research - August 9, 2023 Category: Respiratory Medicine Authors: Emma J. Kooistra, Kilian Dahm, Antonius E. van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L. Smeets, Sjef van der Velde, Maarten J. W. van den Berg, Johannes G. van der Hoeven, Anna C. Aschenbrenner, Joachim L. Schultze, Th Tags: Research Source Type: research
Validation of clinical-radiological scores for prognosis of mortality in acute pulmonary embolism
Acute pulmonary embolism (APE) is a hazardous disorder with a high mortality. Combination of clinical, radiological, and serological parameters can improve risk stratification of APE. Most of the proposed comb... (Source: Respiratory Research)
Source: Respiratory Research - August 5, 2023 Category: Respiratory Medicine Authors: Alexey Surov, Maximilian Thormann, Caroline B är, Andreas Wienke and Jan Borggrefe Tags: Research Source Type: research
Use of thiols and implications for the use of inhaled corticosteroids in the presence of oxidative stress in COPD
Oxidative stress and persistent airway inflammation are thought to be important contributors to the development of chronic obstructive pulmonary disease (COPD). This review summarizes the evidence for targetin... (Source: Respiratory Research)
Source: Respiratory Research - July 31, 2023 Category: Respiratory Medicine Authors: Mario Cazzola, Clive P. Page, Jadwiga A. Wedzicha, Bartolome R. Celli, Antonio Anzueto and Maria Gabriella Matera Tags: Review Source Type: research
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models
Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic po... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2023 Category: Respiratory Medicine Authors: Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu & hellip; Tags: Research Source Type: research
Differential responses of pulmonary vascular cells from PAH patients and controls to TNF α and the effect of the BET inhibitor JQ1
Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2023 Category: Respiratory Medicine Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort and Ian M. Adcock Tags: Research Source Type: research
Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study
Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in ... (Source: Respiratory Research)
Source: Respiratory Research - July 20, 2023 Category: Respiratory Medicine Authors: Arianne K. Baldomero, David M. MacDonald, Adam Kaplan, Eric Lock, Michael H. Cho, Russell Bowler, Lucas Gillenwater, Ken M. Kunisaki and Chris H. Wendt Tags: Research Source Type: research
Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children
Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urina... (Source: Respiratory Research)
Source: Respiratory Research - July 20, 2023 Category: Respiratory Medicine Authors: Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom and Sailesh Kotecha Tags: Research Source Type: research
Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats
Accumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains sparsely studied. We tested effects of Chronic Intermittent Hypoxia (CIH)... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2023 Category: Respiratory Medicine Authors: Mihaela Teodorescu, Ruolin Song, Jacqueline A. Brinkman and Ronald L. Sorkness Tags: Correspondence Source Type: research
Correction: The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium
(Source: Respiratory Research)
Source: Respiratory Research - July 14, 2023 Category: Respiratory Medicine Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang and Qin Wang Tags: Correction Source Type: research
Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling
Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of ad... (Source: Respiratory Research)
Source: Respiratory Research - July 13, 2023 Category: Respiratory Medicine Authors: Taha Kelestemur, Zolt án H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig and György Haskó Tags: Research Source Type: research
Protective effects of inhaled antioxidants against air pollution-induced pathological responses
As the public health burden of air pollution continues to increase, new strategies to mitigate harmful health effects are needed. Dietary antioxidants have previously been explored to protect against air pollu... (Source: Respiratory Research)
Source: Respiratory Research - July 13, 2023 Category: Respiratory Medicine Authors: Kevin D. Schichlein, Gregory J. Smith and Ilona Jaspers Tags: Review Source Type: research
Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population
The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about th... (Source: Respiratory Research)
Source: Respiratory Research - July 12, 2023 Category: Respiratory Medicine Authors: Rajesh Shigdel, Ane Johannessen, Huang Lin, Shyamal Peddada, Francisco G ómez Real, Tamar Ringel-Kulka, Cecilie Svanes and Randi Jacobsen Bertelsen Tags: Comment Source Type: research
LPS binding protein and activation signatures are upregulated during asthma exacerbations in children
Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving ... (Source: Respiratory Research)
Source: Respiratory Research - July 12, 2023 Category: Respiratory Medicine Authors: Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland and Anthony Bosco Tags: Research Source Type: research
