Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures
Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monoc... (Source: Respiratory Research)
Source: Respiratory Research - April 9, 2024 Category: Respiratory Medicine Authors: Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls and Jill A. Poole Tags: Research Source Type: research
GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway
Airway remodelling plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Epithelial –mesenchymal transition (EMT) is a significant process during the occurrence of airway ... (Source: Respiratory Research)
Source: Respiratory Research - April 9, 2024 Category: Respiratory Medicine Authors: Yu Ding, Ziteng Wang, Zheming Zhang, Rong You, Yan Wu and Tao Bian Tags: Research Source Type: research
Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy
Lung cancers represent the main cause of cancer related-death worldwide. Recently, immunotherapy alone or in combination with chemotherapy has deeply impacted the therapeutic care leading to an improved overal... (Source: Respiratory Research)
Source: Respiratory Research - April 5, 2024 Category: Respiratory Medicine Authors: Pauline Hulo, Sophie Deshayes, Judith Fresquet, Anne-Laure Ch éné, Stéphanie Blandin, Nicolas Boisgerault, Jean-François Fonteneau, Lucas Treps, Marc G Denis, Jaafar Bennouna, Delphine Fradin, Elvire Pons-Tostivint and Christophe Blanquart Tags: Research Source Type: research
Updated reference values for static lung volumes from a healthy population in Austria
Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate... (Source: Respiratory Research)
Source: Respiratory Research - April 3, 2024 Category: Respiratory Medicine Authors: Tobias Mraz, Shervin Asgari, Ahmad Karimi, Marie-Kathrin Breyer, Sylvia Hartl, Owat Sunanta, Alina Ofenheimer, Otto C. Burghuber, Angela Zacharasiewicz, Bernd Lamprecht, Caspar Schiffers, Emiel F. M. Wouters and Robab Breyer-Kohansal Tags: Research Source Type: research
A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model
Wnt/ β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human d... (Source: Respiratory Research)
Source: Respiratory Research - April 2, 2024 Category: Respiratory Medicine Authors: Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, H élène Baribault and Russell B. Fletcher Tags: Research Source Type: research
NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive.... (Source: Respiratory Research)
Source: Respiratory Research - April 2, 2024 Category: Respiratory Medicine Authors: Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang and Guoying Yu Tags: Research Source Type: research
The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS
EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than s... (Source: Respiratory Research)
Source: Respiratory Research - April 1, 2024 Category: Respiratory Medicine Authors: Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leont Tags: Research Source Type: research
Correction: Benefit of prompt initiation of single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) in patients with COPD in England following an exacerbation: a retrospective cohort study
(Source: Respiratory Research)
Source: Respiratory Research - April 1, 2024 Category: Respiratory Medicine Authors: Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey and David M. G. Halpin Tags: Correction Source Type: research
A novel quinoline with airway relaxant effects and anti-inflammatory properties
In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds ... (Source: Respiratory Research)
Source: Respiratory Research - March 30, 2024 Category: Respiratory Medicine Authors: Jesper Bergwik, Jielu Liu, M édea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten and Mikael Adner Tags: Research Source Type: research
Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically activated M1 macrophages and alternatively activated M2 macrop... (Source: Respiratory Research)
Source: Respiratory Research - March 30, 2024 Category: Respiratory Medicine Authors: Yifan Zuo, Boyang Li, Minglang Gao, Rui Xiong, Ruyuan He, Ning Li and Qing Geng Tags: Review Source Type: research
Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway
Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary dis... (Source: Respiratory Research)
Source: Respiratory Research - March 30, 2024 Category: Respiratory Medicine Authors: Haidong Ding, Liming Yan, Yu Wang, Ye Lu, Mingming Deng, Yingxi Wang, Qiuyue Wang and Xiaoming Zhou Tags: Research Source Type: research
Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study
The clinical significance of the impulse oscillometry-defined small airway bronchodilator response (IOS-BDR) is not well-known. Accordingly, this study investigated the clinical characteristics of IOS-BDR and ... (Source: Respiratory Research)
Source: Respiratory Research - March 30, 2024 Category: Respiratory Medicine Authors: Lifei Lu, Fan Wu, Jieqi Peng, Xiaohui Wu, Xiangqing Hou, Youlan Zheng, Huajing Yang, Zhishan Deng, Cuiqiong Dai, Ningning Zhao, Kunning Zhou, Qi Wan, Gaoying Tang, Jiangyu Cui, Shuqing Yu, Xiangwen Luo & hellip; Tags: Research Source Type: research
Longitudinal BMI change and outcomes in Chronic Obstructive Pulmonary Disease: a nationwide population-based cohort study
The association between longitudinal body mass index (BMI) change and clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) has not fully investigated. (Source: Respiratory Research)
Source: Respiratory Research - March 30, 2024 Category: Respiratory Medicine Authors: Taeyun Kim, Sun Hye Shin, Hyunsoo Kim, Yunjoo Im, Juhee Cho, Danbee Kang and Hye Yun Park Tags: Research Source Type: research
Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study
Although ROX index is frequently used to assess the efficacy of high-flow nasal cannula treatment in acute hypoxemic respiratory failure (AHRF) patients, the relationship between the ROX index and the mortalit... (Source: Respiratory Research)
Source: Respiratory Research - March 29, 2024 Category: Respiratory Medicine Authors: Kai Liu, Xin-Yi Ma, Hua Xiao, Wan-Jie Gu, Jun Lyu and Hai-Yan Yin Tags: Research Source Type: research
Development of a nomogram based on the clinicopathological and CT features to predict the survival of primary pulmonary lymphoepithelial carcinoma patients
The aim of this study was to develop a nomogram by combining chest computed tomography (CT) images and clinicopathological predictors to assess the survival outcomes of patients with primary pulmonary lymphoep... (Source: Respiratory Research)
Source: Respiratory Research - March 29, 2024 Category: Respiratory Medicine Authors: Kai Nie, Lin Zhu, Yuxuan Zhang, Yinan Chen, John Parrington and Hong Yu Tags: Research Source Type: research
