Modeled small airways lung deposition of two fixed-dose triple therapy combinations assessed with in silico functional respiratory imaging
This study ev... (Source: Respiratory Research)
Source: Respiratory Research - September 23, 2023 Category: Respiratory Medicine Authors: Omar Usmani, Grace Li, Jan De Backer, Hosein Sadafi, Libo Wu and Jonathan Marshall Tags: Research Source Type: research
CTGF promotes the repair and regeneration of alveoli after acute lung injury by promoting the proliferation of subpopulation of AEC2s
Functional alveolar regeneration is essential for the restoration of normal lung homeostasis after acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Lung is a relatively quiescent organ a... (Source: Respiratory Research)
Source: Respiratory Research - September 23, 2023 Category: Respiratory Medicine Authors: Jianhui Sun, Huacai Zhang, Di Liu, Wenyi Liu, Juan Du, Dalin Wen, Luoxi Li, Anqiang Zhang, Jianxin Jiang and Ling Zeng Tags: Research Source Type: research
Correction to: L1077P CFTR pathogenic variant function rescue by Elexacaftor –Tezacaftor–Ivacaftor in cystic fbrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
(Source: Respiratory Research)
Source: Respiratory Research - September 23, 2023 Category: Respiratory Medicine Authors: Stefania Lo Cicero, Germana Castelli, Giovanna Blacon à, Sabina Maria Bruno, Giovanni Sette, Riccardo Pigliucci, Valeria Rachela Villella, Speranza Esposito, Immacolata Zollo, Francesca Spadaro, Ruggero De Maria, Mauro Biffoni, Giuseppe Cimino, Felice Am Tags: Correction Source Type: research
Incident low muscle mass is associated with greater lung disease and lower circulating leptin in a tobacco-exposed longitudinal cohort
Muscle loss is prevalent in chronic obstructive pulmonary disease (COPD). Prior studies evaluating musculoskeletal dysfunction in COPD have focused on individuals with baseline low muscle mass. Currently, ther... (Source: Respiratory Research)
Source: Respiratory Research - September 22, 2023 Category: Respiratory Medicine Authors: Richard H. Zou, S. Mehdi Nouraie, Chad Karoleski, Yingze Zhang, Frank C. Sciurba, Daniel E. Forman and Jessica Bon Tags: Research Source Type: research
Staphylococcus aureus enterotoxin A- and B-specific IgE in chronic obstructive pulmonary disease
Sensitization to Staphylococcus aureus enterotoxins A (SEA) and B (SEB) has been associated with asthma severity, exacerbations, and disease control. Our study aimed to investigate if there are differences in ... (Source: Respiratory Research)
Source: Respiratory Research - September 22, 2023 Category: Respiratory Medicine Authors: Meropi Karakioulaki, Caroline Maria Berkemeier, Ingmar Heijnen, Leticia Grize, Eleni Papakonstantinou, Antonis Goulas, Michael Tamm and Daiana Stolz Tags: Correspondence Source Type: research
Predictors of the response to phosphodiesterase-5 inhibitors in pulmonary arterial hypertension: an analysis of the Spanish registry
Achieving and maintaining a low-risk profile is associated with favorable outcome in pulmonary arterial hypertension (PAH). The effects of treatment on risk profile are variable among patients. (Source: Respiratory Research)
Source: Respiratory Research - September 15, 2023 Category: Respiratory Medicine Authors: Agustin R. Garcia, Isabel Blanco, Lluis Ramon, Jes ús Pérez-Sagredo, Francisco J. Guerra-Ramos, Clara Martín-Ontiyuelo, Olga Tura-Ceide, Francisco Pastor-Pérez, Pilar Escribano-Subías and Joan A. Barberà Tags: Research Source Type: research
TGF β1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation
Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is required to develop alternative therapeutic stra... (Source: Respiratory Research)
Source: Respiratory Research - September 14, 2023 Category: Respiratory Medicine Authors: Mingting Wu, Zhenyan Wang, Xiaoqian Shi, Danni Zan, Hong Chen, Shuqiao Yang, Fangping Ding, Liu Yang, Pingping Tan, Runlin Z. Ma, Jing Wang, Lishuang Ma, Yingmin Ma and Jiawei Jin Tags: Research Source Type: research
Airway inflammatory changes in the lungs of patients with asthma-COPD overlap (ACO): a bronchoscopy endobronchial biopsy study
Although asthma and chronic obstructive pulmonary disease (COPD) are two distinct chronic airway inflammatory diseases, they often co-exist in a patient and the condition is referred to as asthma-COPD overlap ... (Source: Respiratory Research)
Source: Respiratory Research - September 12, 2023 Category: Respiratory Medicine Authors: Surajit Dey, Wenying Lu, Greg Haug, Collin Chia, Josie Larby, Heinrich C. Weber, Archana Vijay Gaikwad, Prem Bhattarai, Affan Mahmood Shahzad, Prabuddha S. Pathinayake, Peter A. B. Wark, Mathew Suji Eapen and Sukhwinder Singh Sohal Tags: Research Source Type: research
A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study
Pulmonary arterial hypertension is a major cause of death in systemic lupus erythematosus, but there are no tools specialized for predicting survival in systemic lupus erythematosus-associated pulmonary arteri... (Source: Respiratory Research)
Source: Respiratory Research - September 9, 2023 Category: Respiratory Medicine Authors: Jingge Qu, Mengtao Li, Xiao Zhang, Miaojia Zhang, Xiaoxia Zuo, Ping Zhu, Shuang Ye, Wei Zhang, Yi Zheng, Wufang Qi, Yang Li, Zhuoli Zhang, Feng Ding, Jieruo Gu, Yi Liu, Junyan Qian & hellip; Tags: Research Source Type: research
Variants in transient receptor potential channels and toll-like receptors modify airway responses to allergen and air pollution: a randomized controlled response human exposure study
Environmental co-exposure to allergen and traffic-related air pollution is common globally and contributes to the exacerbation of respiratory diseases. Individual responses to environmental insults remain vari... (Source: Respiratory Research)
Source: Respiratory Research - September 7, 2023 Category: Respiratory Medicine Authors: Andrew Robinson, Ryan D. Huff, Min Hyung Ryu and Chris Carlsten Tags: Research Source Type: research
SACE and IL-2R as serum biomarkers for evaluation of multi-organ involvement and prognosis of sarcoidosis
Serum biomarkers in the evaluation of organ involvement and prognostic monitoring of sarcoidosis have not been determined. The purpose of this study was to identify common biomarkers that could be used to asse... (Source: Respiratory Research)
Source: Respiratory Research - September 7, 2023 Category: Respiratory Medicine Authors: Ying Zhou, Xianqiu Chen, Mengmeng Zhao, Elyse E. Lower and Robert P. Baughman Tags: Research Source Type: research
L1077P CFTR pathogenic variant function rescue by Elexacaftor –Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR-modulating drugs may overcome specific defects, such as the case of Trikafta, which is a c... (Source: Respiratory Research)
Source: Respiratory Research - September 6, 2023 Category: Respiratory Medicine Authors: Lo Cicero Stefania, Castelli Germana, Blacon à Giovanna, Bruno Sabina Maria, Sette Giovanni, Pigliucci Riccardo, Villella Valeria Rachela, Esposito Speranza, Zollo Immacolata, Spadaro Francesca, De Maria Ruggero, Biffoni Mauro, Cimino Giuseppe, Amato Fel Tags: Research Source Type: research
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
Macrophage migration inhibitory factor (MIF) and GTPase dynamin-related protein 1 (Drp1)-dependent aberrant mitochondrial fission are closely linked to the pathogenesis of asthma. However, it is unclear whethe... (Source: Respiratory Research)
Source: Respiratory Research - September 6, 2023 Category: Respiratory Medicine Authors: Jin Liu, Yuqian Chen, Huan Chen, Yan Wang, Danyang Li, Qianqian Zhang, Limin Chai, Yuanjie Qiu, Jia Zhang, Nirui Shen, Qingting Wang, Jian Wang and Manxiang Li Tags: Research Source Type: research
Quantifying ventilation by X-ray velocimetry in healthy adults
X-ray velocimetry (XV) has been utilized in preclinical models to assess lung motion and regional ventilation, though no studies have compared XV-derived physiologic parameters to measures derived through conv... (Source: Respiratory Research)
Source: Respiratory Research - August 30, 2023 Category: Respiratory Medicine Authors: Trishul Siddharthan, Kyle Grealis, Jason P. Kirkness, Tam ás Ötvös, Darko Stefanovski, Alex Tombleson, Molly Dalzell, Ernesto Gonzalez, Kinjal Bhatt Nakrani, David Wenger, Michael G. Lester, Bradley W. Richmond, Andreas Fouras and Naresh M. Punjabi Tags: Research Source Type: research
Dexmedetomidine alleviates pulmonary fibrosis through the ADORA2B-Mediated MAPK signaling pathway
Idiopathic pulmonary fibrosis (IPF) is a chronically progressive fibrotic pulmonary disease characterized by an uncertain etiology, a poor prognosis, and a paucity of efficacious treatment options. Dexmedetomi... (Source: Respiratory Research)
Source: Respiratory Research - August 29, 2023 Category: Respiratory Medicine Authors: Xiaofan Lai, Yingying Lin, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang and Wenqi Huang Tags: Research Source Type: research
