3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function
The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides mechanical support, stability and elastic recoil for different pulmonary cells including the lung fibroblasts. The ECM plays... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Sakshi Phogat, Fama Thiam, Safiya Al Yazeedi, Filsan Ahmed Abokor and Emmanuel Twumasi Osei Tags: Review Source Type: research
Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan
Computed tomography (CT) imaging and artificial intelligence (AI)-based analyses have aided in the diagnosis and prediction of the severity of COVID-19. However, the potential of AI-based CT quantification of ... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda Tags: Research Source Type: research
Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples
Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by airflow-limiting inflammation and mucus production. Acute exacerbations are a major cause of COPD-related morbidity and mortality... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants and Silvia Rossi Paccani Tags: Research Source Type: research
KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) has an unknown aetiology and limited treatment options. A recent meta-analysis identified three novel causal variants in the TERT, SPDL1, and KIF15 genes. This observational st... (Source: Respiratory Research)
Source: Respiratory Research - September 30, 2023 Category: Respiratory Medicine Authors: Maria Hollm én, Atte Laaka, Juulia J. Partanen, Jukka Koskela, Eva Sutinen, Riitta Kaarteenaho, Mari Ainola and Marjukka Myllärniemi Tags: Research Source Type: research
Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells
Airway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to chronic airway disease (CAD) can cause ABSC dysfunction, it remains uncle... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu and Shi-Yue Li Tags: Research Source Type: research
Rhinovirus induces airway remodeling: what are the physiological consequences?
Rhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with injury-repair responses in the airways that collectively contribute to airwa... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr. and Cynthia J. Koziol-White Tags: Review Source Type: research
Comparative cardiovascular safety of LABA/LAMA FDC versus LABA/ICS FDC in patients with chronic obstructive pulmonary disease: a population-based cohort study with a target trial emulation framework
Use of combinations of long-acting β2 agonists/long-acting muscarinic antagonists (LABA/LAMA) in patients with chronic obstructive pulmonary disease (COPD) is increasing. Nevertheless, existing evidence on cardio... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Chun-Yu Chen, Sheng-Wei Pan, Chia-Chen Hsu, Jason J. Liu, Hiraku Kumamaru and Yaa-Hui Dong Tags: Research Source Type: research
Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: orbe II study
The ORBE II study aimed to describe the characteristics and clinical outcomes of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting in Spain. (Source: Respiratory Research)
Source: Respiratory Research - September 28, 2023 Category: Respiratory Medicine Authors: Alicia Padilla-Galo, Isabel Moya Carmona, Pilar Aus ín, Luis Carazo Fernández, Ismael García-Moguel, José Luis Velasco-Garrido, Rubén Andújar-Espinosa, Francisco Casas-Maldonado, Eva Martínez-Moragón, Carlos Martínez Rivera, Elisabet Vera Solsona Tags: Research Source Type: research
Lung immune signatures define two groups of end-stage IPF patients
The role of the immune system in the pathobiology of Idiopathic Pulmonary Fibrosis (IPF) is controversial. (Source: Respiratory Research)
Source: Respiratory Research - September 28, 2023 Category: Respiratory Medicine Authors: Tamara Cruz, N úria Mendoza, Sandra Casas-Recasens, Guillaume Noell, Fernanda Hernandez-Gonzalez, Alejandro Frino-Garcia, Xavi Alsina-Restoy, María Molina, Mauricio Rojas, Alvar Agustí, Jacobo Sellares and Rosa Faner Tags: Research Source Type: research
Mesenchymal stem cell-derived extracellular vesicles prevent the formation of pulmonary arterial hypertension through a microRNA-200b-dependent mechanism
Bone marrow mesenchymal stem cell-derived extracellular vesicles (BMSC-EVs) have been highly studied with their critical roles as carriers of therapeutic targets such as microRNAs (miRNAs) in the treatment of ... (Source: Respiratory Research)
Source: Respiratory Research - September 27, 2023 Category: Respiratory Medicine Authors: Mengzhi Wan, Caiju Lu, Yu Liu, Feng Luo, Jing Zhou and Fei Xu Tags: Research Source Type: research
A biphasic effect of age on CPAP adherence: a cross-sectional study of 26,343 patients
As the prevalence of OSA increases in older patients, the proportion of elderly patients treated with CPAP is expected to become even higher. We studied CPAP-adherence in a real-life cohort involving a large p... (Source: Respiratory Research)
Source: Respiratory Research - September 27, 2023 Category: Respiratory Medicine Authors: Arnaud Prigent, Cl ément Blanloeil, Anne-Laure Serandour, Franck Barlet, Pr Frédéric Gagnadoux and Dany Jaffuel Tags: Correspondence Source Type: research
Early vvECMO implantation may be associated with lower mortality in ARDS
Venovenous extracorporeal membrane oxygenation (vvECMO) is used to treat hypoxia in patients with severe acute respiratory distress syndrome (ARDS). Nevertheless, uncertainty exists regarding the optimal timin... (Source: Respiratory Research)
Source: Respiratory Research - September 26, 2023 Category: Respiratory Medicine Authors: Peter Rosenberger, Lisa Korell, Helene A. Haeberle, Valbona Mirakaj, Alice Bernard, Linyan Tang, Andreas K örner, Peter Martus and Michael Koeppen Tags: Research Source Type: research
Eosinophil extracellular traps in asthma: implications for pathogenesis and therapy
Asthma is a common, chronic inflammatory disease of the airways that affects millions of people worldwide and is associated with significant healthcare costs. Eosinophils, a type of immune cell, play a critica... (Source: Respiratory Research)
Source: Respiratory Research - September 26, 2023 Category: Respiratory Medicine Authors: Kunlu Shen, Mengyuan Zhang, Ruiheng Zhao, Yun Li, Chunxiao Li, Xin Hou, Bingqing Sun, Bowen Liu, Min Xiang and Jiangtao Lin Tags: Review Source Type: research
Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients
The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients w... (Source: Respiratory Research)
Source: Respiratory Research - September 26, 2023 Category: Respiratory Medicine Authors: Christian R ønn, Peter Kamstrup, Josefin Eklöf, Louise Lindhardt Toennesen, Jonas Bredtoft Boel, Christian Ostergaard Andersen, Ram Benny Dessau, Jon Torgny Wilcke, Pradeesh Sivapalan, Charlotte Suppli Ulrik and Jens-Ulrik Stæhr Jensen Tags: Research Source Type: research
Benefit of prompt initiation of single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) in patients with COPD in England following an exacerbation: a retrospective cohort study
Triple therapy is recommended for patients with chronic obstructive pulmonary disease (COPD) who remain symptomatic despite dual therapy. The optimal timing of triple therapy following an exacerbation of COPD ... (Source: Respiratory Research)
Source: Respiratory Research - September 25, 2023 Category: Respiratory Medicine Authors: Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey and David M. G. Halpin Tags: Research Source Type: research
