Dysregulation of iron homeostasis in airways associated with persistent preschool wheezing
Currently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent wheezing. We investigated iron homeostasis in the airways of preschooler... (Source: Respiratory Research)
Source: Respiratory Research - June 23, 2023 Category: Respiratory Medicine Authors: Zhili Wang, Yu He, Qinyuan Li, Yan Zhao, Guangli Zhang and Zhengxiu Luo Tags: Correspondence Source Type: research

Plasma matrix metalloproteinase-3 predicts mortality in acute respiratory distress syndrome: a biomarker analysis of a randomized controlled trial
Matrix metalloproteinase-3 (MMP-3) is a proteolytic enzyme involved in acute respiratory distress syndrome (ARDS) pathophysiology that may serve as a lung-specific biomarker in ARDS. (Source: Respiratory Research)
Source: Respiratory Research - June 22, 2023 Category: Respiratory Medicine Authors: Timothy W. Jones, Sultan Almuntashiri, Aaron Chase, Abdullah Alhumaid, Payaningal R. Somanath, Andrea Sikora and Duo Zhang Tags: Correspondence Source Type: research

NO-sensitive guanylyl cyclase discriminates pericyte-derived interstitial from intra-alveolar myofibroblasts in murine pulmonary fibrosis
The origin of αSMA-positive myofibroblasts, key players within organ fibrosis, is still not fully elucidated. Pericytes have been discussed as myofibroblast progenitors in several organs including the lung. (Source: Respiratory Research)
Source: Respiratory Research - June 22, 2023 Category: Respiratory Medicine Authors: Annemarie Aue, Nils Englert, Leon Harrer, Fabian Schwiering, Annika Gaab, Peter K önig, Ralf Adams, Achim Schmidtko, Andreas Friebe and Dieter Groneberg Tags: Research Source Type: research

CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension
Pulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary disease mainly characterized by pulmonary vascular remodeling. Aberrant expression of circRNAs has been reported to play a crucial role... (Source: Respiratory Research)
Source: Respiratory Research - June 21, 2023 Category: Respiratory Medicine Authors: Hua Su, Huiqi Zhu, Sihao Wang, Yeping Li, Chao Yan, Jiaoyan Wang and Kejing Ying Tags: Research Source Type: research

A blood microRNA classifier for the prediction of ICU mortality in COVID-19 patients: a multicenter validation study
The identification of critically ill COVID-19 patients at risk of fatal outcomes remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers for clinical decision-making in critica... (Source: Respiratory Research)
Source: Respiratory Research - June 17, 2023 Category: Respiratory Medicine Authors: David de Gonzalo-Calvo, Marta Molinero, Iv án D. Benítez, Manel Perez-Pons, Nadia García-Mateo, Alicia Ortega, Tamara Postigo, María C. García-Hidalgo, Thalia Belmonte, Carlos Rodríguez-Muñoz, Jessica González, Gerard Torres, Clara Gort-Paniello, Tags: Research Source Type: research