Differential responses of pulmonary vascular cells from PAH patients and controls to TNF α and the effect of the BET inhibitor JQ1
Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal... (Source: Respiratory Research)
Source: Respiratory Research - July 29, 2023 Category: Respiratory Medicine Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort and Ian M. Adcock Tags: Research Source Type: research
Bilirubin-associated single nucleotide polymorphism (SNP) and respiratory health outcomes: a mendelian randomization study
Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in ... (Source: Respiratory Research)
Source: Respiratory Research - July 20, 2023 Category: Respiratory Medicine Authors: Arianne K. Baldomero, David M. MacDonald, Adam Kaplan, Eric Lock, Michael H. Cho, Russell Bowler, Lucas Gillenwater, Ken M. Kunisaki and Chris H. Wendt Tags: Research Source Type: research
Characterizing the urinary proteome of prematurity-associated lung disease in school-aged children
Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urina... (Source: Respiratory Research)
Source: Respiratory Research - July 20, 2023 Category: Respiratory Medicine Authors: Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom and Sailesh Kotecha Tags: Research Source Type: research
Chronic intermittent hypoxia increases airway hyperresponsiveness during house dust mites exposures in rats
Accumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains sparsely studied. We tested effects of Chronic Intermittent Hypoxia (CIH)... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2023 Category: Respiratory Medicine Authors: Mihaela Teodorescu, Ruolin Song, Jacqueline A. Brinkman and Ronald L. Sorkness Tags: Correspondence Source Type: research
Correction: The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium
(Source: Respiratory Research)
Source: Respiratory Research - July 14, 2023 Category: Respiratory Medicine Authors: Yidan Ren, Yi Zhang, Lixia Fan, Qinlian Jiao, Yunshan Wang and Qin Wang Tags: Correction Source Type: research
Adenosine metabolized from extracellular ATP ameliorates organ injury by triggering A2BR signaling
Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of ad... (Source: Respiratory Research)
Source: Respiratory Research - July 13, 2023 Category: Respiratory Medicine Authors: Taha Kelestemur, Zolt án H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig and György Haskó Tags: Research Source Type: research
Protective effects of inhaled antioxidants against air pollution-induced pathological responses
As the public health burden of air pollution continues to increase, new strategies to mitigate harmful health effects are needed. Dietary antioxidants have previously been explored to protect against air pollu... (Source: Respiratory Research)
Source: Respiratory Research - July 13, 2023 Category: Respiratory Medicine Authors: Kevin D. Schichlein, Gregory J. Smith and Ilona Jaspers Tags: Review Source Type: research
Oral bacterial composition associated with lung function and lung inflammation in a community-based Norwegian population
The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about th... (Source: Respiratory Research)
Source: Respiratory Research - July 12, 2023 Category: Respiratory Medicine Authors: Rajesh Shigdel, Ane Johannessen, Huang Lin, Shyamal Peddada, Francisco G ómez Real, Tamar Ringel-Kulka, Cecilie Svanes and Randi Jacobsen Bertelsen Tags: Comment Source Type: research
LPS binding protein and activation signatures are upregulated during asthma exacerbations in children
Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving ... (Source: Respiratory Research)
Source: Respiratory Research - July 12, 2023 Category: Respiratory Medicine Authors: Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland and Anthony Bosco Tags: Research Source Type: research
AMPK activation improves recovery from pneumonia-induced lung injury via reduction of er-stress and apoptosis in alveolar epithelial cells
Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious and prolonged respiratory complications among survivors. Given that... (Source: Respiratory Research)
Source: Respiratory Research - July 12, 2023 Category: Respiratory Medicine Authors: Eugene Becker Jr., Maroof Husain, Nathaniel Bone, Samuel Smith, Peter Morris and Jaroslaw W. Zmijewski Tags: Research Source Type: research
Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption
Alveolar epithelial barrier is a potential therapeutic target for acute respiratory distress syndrome (ARDS). However, an effective intervention against alveolar epithelial barrier has not been developed. Here... (Source: Respiratory Research)
Source: Respiratory Research - July 11, 2023 Category: Respiratory Medicine Authors: Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng and Liang Dong Tags: Research Source Type: research
Correction to: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p –HMGB1 axis
(Source: Respiratory Research)
Source: Respiratory Research - July 10, 2023 Category: Respiratory Medicine Authors: Mingming Jin, Yan Wang, Dawei Zhou, Wanchao Liu, Ruodong Han and Yongbin Chi Tags: Correction Source Type: research
Enhancing the interferon- γ release assay through omission of nil and mitogen values
To address the limited utility of the interferon (IFN)- γ release assay (IGRA) caused by its variability and inconsistency. (Source: Respiratory Research)
Source: Respiratory Research - July 7, 2023 Category: Respiratory Medicine Authors: Yun Jung Jung, Ji Eun Park, Ji Won Park, Keu Sung Lee, Wou Young Chung, Joo Hun Park, Seung Soo Sheen, Seulgi You, Joo Sung Sun, Kyung Joo Park, Youn Jung Kim and Kwang Joo Park Tags: Research Source Type: research
High apoptotic endothelial microparticle levels measured in asthma with elevated IgE and eosinophils
While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling a... (Source: Respiratory Research)
Source: Respiratory Research - July 7, 2023 Category: Respiratory Medicine Authors: Yael Strulovici-Barel, Robert J. Kaner and Ronald G. Crystal Tags: Correspondence Source Type: research
Deciphering a cell death-associated signature for predicting prognosis and response to immunotherapy in lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC) is a subtype of non-small cell carcinoma, accounting for about 30% of all lung cancers. Yet, the evaluation of prognostic outcome and therapy response of patients with LUSC ... (Source: Respiratory Research)
Source: Respiratory Research - July 6, 2023 Category: Respiratory Medicine Authors: Guangxian Mao, Dongyong Yang, Bin Liu, Yu Zhang, Sijia Ma, Shang Dai, Guoqiang Wang, Wenxiang Tang, Huafei Lu, Shangli Cai, Jialiang Zhu and Huaping Yang Tags: Research Source Type: research
