Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort
Platelet count (PLT) is associated positively with lung cancer risk but has a more complex association with body mass index (BMI), positive only in women (mainly never smokers) and inverse in men (mainly ever ... (Source: Respiratory Research)
Source: Respiratory Research - October 17, 2023 Category: Respiratory Medicine Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou and Elio Riboli Tags: Research Source Type: research

Microbial signatures in amniotic fluid at preterm birth and association with bronchopulmonary dysplasia
Microbiome dysbiosis can have long-lasting effects on our health and induce the development of various diseases. Bronchopulmonary dysplasia (BPD) is a multifactorial disease with pre- and postnatal origins inc... (Source: Respiratory Research)
Source: Respiratory Research - October 16, 2023 Category: Respiratory Medicine Authors: Birte Staude, Silvia Gschwendtner, Tina Frodermann, Frank Oehmke, Thomas Kohl, Susanne Kublik, Michael Schloter and Harald Ehrhardt Tags: Research Source Type: research

Effectiveness of the booster dose of inactivated COVID-19 vaccine against Omicron BA.5 infection: a matched cohort study of adult close contacts
Although COVID-19 vaccines and their booster regimens protect against symptomatic infections and severe outcomes, there is limited evidence about their protection against asymptomatic and symptomatic infection... (Source: Respiratory Research)
Source: Respiratory Research - October 12, 2023 Category: Respiratory Medicine Authors: Ting Zeng, Yaoqin Lu, Yanji Zhao, Zihao Guo, Shengzhi Sun, Zhidong Teng, Maozai Tian, Jun Wang, Shulin Li, Xucheng Fan, Weiming Wang, Yongli Cai, Gengze Liao, Xiao Liang, Daihai He, Kai Wang & hellip; Tags: Research Source Type: research

Targeting Rev-Erb α to protect against ischemia-reperfusion-induced acute lung injury in rats
The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erb α in ischemia-reper... (Source: Respiratory Research)
Source: Respiratory Research - October 12, 2023 Category: Respiratory Medicine Authors: Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu and Shih-En Tang Tags: Research Source Type: research

Bronchial epithelial gene expression and interstitial lung abnormalities
Interstitial lung abnormalities (ILA) often represent early fibrotic changes that can portend a progressive fibrotic phenotype. In particular, the fibrotic subtype of ILA is associated with increased mortality... (Source: Respiratory Research)
Source: Respiratory Research - October 10, 2023 Category: Respiratory Medicine Authors: Aravind A. Menon, Minyi Lee, Xu Ke, Rachel K. Putman, Takuya Hino, Jonathan A. Rose, Fenghai Duan, Samuel Y. Ash, Michael H. Cho, George T. O ’Connor, Josée Dupuis, Hiroto Hatabu, Marc E. Lenburg, Ehab S. Billatos and Gary M. Hunninghake Tags: Correspondence Source Type: research

The effect of inhaled extrafine beclometasone dipropionate/formoterol fumarate/glycopyrronium bromide on distal and central airway indices, assessed using Functional Respiratory Imaging in COPD (DARWiIN)
This study, in patients with symptomatic chronic obstructive pulmonary disease (COPD), explored switching therapy from non-extrafine high-dose inhaled corticosteroid/long-acting β2-agonist (ICS/LABA; fluticasone ... (Source: Respiratory Research)
Source: Respiratory Research - October 6, 2023 Category: Respiratory Medicine Authors: Gwen S. Skloot, Alessandro Guasconi, Benjamin R. Lavon, George Georges, Wilfried De Backer, Dmitry Galkin, Mauro Cortellini, Ilaria Panni and Jason H. T. Bates Tags: Research Source Type: research

3D in vitro hydrogel models to study the human lung extracellular matrix and fibroblast function
The pulmonary extracellular matrix (ECM) is a macromolecular structure that provides mechanical support, stability and elastic recoil for different pulmonary cells including the lung fibroblasts. The ECM plays... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Sakshi Phogat, Fama Thiam, Safiya Al Yazeedi, Filsan Ahmed Abokor and Emmanuel Twumasi Osei Tags: Review Source Type: research

Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan
Computed tomography (CT) imaging and artificial intelligence (AI)-based analyses have aided in the diagnosis and prediction of the severity of COVID-19. However, the potential of AI-based CT quantification of ... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda Tags: Research Source Type: research

Ex-vivo RNA expression analysis of vaccine candidate genes in COPD sputum samples
Chronic obstructive pulmonary disease (COPD) is a lung disease characterised by airflow-limiting inflammation and mucus production. Acute exacerbations are a major cause of COPD-related morbidity and mortality... (Source: Respiratory Research)
Source: Respiratory Research - October 5, 2023 Category: Respiratory Medicine Authors: Cecilia Brettoni, Alessandro Muzzi, Simona Rondini, Vincent Weynants and Silvia Rossi Paccani Tags: Research Source Type: research

KIF15 missense variant is associated with the early onset of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) has an unknown aetiology and limited treatment options. A recent meta-analysis identified three novel causal variants in the TERT, SPDL1, and KIF15 genes. This observational st... (Source: Respiratory Research)
Source: Respiratory Research - September 30, 2023 Category: Respiratory Medicine Authors: Maria Hollm én, Atte Laaka, Juulia J. Partanen, Jukka Koskela, Eva Sutinen, Riitta Kaarteenaho, Mari Ainola and Marjukka Myllärniemi Tags: Research Source Type: research

Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells
Airway basal stem cells (ABSCs) have self-renewal and differentiation abilities. Although an abnormal mechanical environment related to chronic airway disease (CAD) can cause ABSC dysfunction, it remains uncle... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Li-Qin Lin, Hai-Kang Zeng, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu and Shi-Yue Li Tags: Research Source Type: research

Rhinovirus induces airway remodeling: what are the physiological consequences?
Rhinovirus infections commonly evoke asthma exacerbations in children and adults. Recurrent asthma exacerbations are associated with injury-repair responses in the airways that collectively contribute to airwa... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Cassandra Spector, Camden M. De Sanctis, Reynold A. Panettieri Jr. and Cynthia J. Koziol-White Tags: Review Source Type: research

Comparative cardiovascular safety of LABA/LAMA FDC versus LABA/ICS FDC in patients with chronic obstructive pulmonary disease: a population-based cohort study with a target trial emulation framework
Use of combinations of long-acting β2 agonists/long-acting muscarinic antagonists (LABA/LAMA) in patients with chronic obstructive pulmonary disease (COPD) is increasing. Nevertheless, existing evidence on cardio... (Source: Respiratory Research)
Source: Respiratory Research - September 29, 2023 Category: Respiratory Medicine Authors: Chun-Yu Chen, Sheng-Wei Pan, Chia-Chen Hsu, Jason J. Liu, Hiraku Kumamaru and Yaa-Hui Dong Tags: Research Source Type: research

Achieving clinical outcomes with benralizumab in severe eosinophilic asthma patients in a real-world setting: orbe II study
The ORBE II study aimed to describe the characteristics and clinical outcomes of adult patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting in Spain. (Source: Respiratory Research)
Source: Respiratory Research - September 28, 2023 Category: Respiratory Medicine Authors: Alicia Padilla-Galo, Isabel Moya Carmona, Pilar Aus ín, Luis Carazo Fernández, Ismael García-Moguel, José Luis Velasco-Garrido, Rubén Andújar-Espinosa, Francisco Casas-Maldonado, Eva Martínez-Moragón, Carlos Martínez Rivera, Elisabet Vera Solsona Tags: Research Source Type: research

Lung immune signatures define two groups of end-stage IPF patients
The role of the immune system in the pathobiology of Idiopathic Pulmonary Fibrosis (IPF) is controversial. (Source: Respiratory Research)
Source: Respiratory Research - September 28, 2023 Category: Respiratory Medicine Authors: Tamara Cruz, N úria Mendoza, Sandra Casas-Recasens, Guillaume Noell, Fernanda Hernandez-Gonzalez, Alejandro Frino-Garcia, Xavi Alsina-Restoy, María Molina, Mauricio Rojas, Alvar Agustí, Jacobo Sellares and Rosa Faner Tags: Research Source Type: research