Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
ConclusionsThe present study revealed that neuronal Panx1 is a prominent driver of peripheral sensitivity in the setting of inflammatory pain through cell-autonomous effects on neuronal excitability. This hyperexcitability dependence on neuronal Panx1 contrasts with inflammatory orofacial pain, where similar studies revealed a prominent role for glial Panx1. The apparent differences in Panx1 expression in neuronal and non-neuronal TG and DRG cells are likely responsible for the distinct impact of these cell types in the two pain models. (Source: Military Medical Research)
Source: Military Medical Research - April 29, 2024 Category: International Medicine & Public Health Source Type: research
CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
(Source: Military Medical Research)
Source: Military Medical Research - April 23, 2024 Category: International Medicine & Public Health Source Type: research
N-terminal pro-brain natriuretic peptide – a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke
(Source: Military Medical Research)
Source: Military Medical Research - April 23, 2024 Category: International Medicine & Public Health Source Type: research
Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
AbstractSepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of intercellular communication, play a pivotal role in the pathogenesis of sepsis through modulating immune responses, metabolic reprogramming, coagulopathy, and organ dysfunction. This review highlights the emerging significance of exosomes in these processes. Initially, it provides an in-depth insight into exosome biogenesis and characterization, laying the groundwork for understanding their diverse and intricate functions. Subsequently, it explores the regulatory role...
Source: Military Medical Research - April 22, 2024 Category: International Medicine & Public Health Source Type: research
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
AbstractChronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of underlying comorbidities, such as diabetes or vascular diseases, lifestyle factors, and genetic risk profiles which may predispose extremities to local ischemia. Injuries are further exacerbated by bacterial colonization and the formation of biofilms. Infection, consequently, perpetuates a chronic inflammatory microenvironment, preventing the progression and completion of normal wound healing. The current standar...
Source: Military Medical Research - April 18, 2024 Category: International Medicine & Public Health Source Type: research
Interferon- α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
ConclusionsThis study provides mechanistic evidence that IFN- α stimulates DHX58 to promote the translation of m6A-modifiedGpx4 mRNA, suggesting the potential clinical application of IFN- α in the prevention of hepatic ferroptosis during liver I/R injury. (Source: Military Medical Research)
Source: Military Medical Research - April 15, 2024 Category: International Medicine & Public Health Source Type: research
The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
AbstractIn recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments in the current era, particularly the emerging integration of single-cell and spatiotemporal transcriptomics, have enabled a detailed molecular comprehension of the complex regulation of cell fate. The insights obtained from these methodologies are anticipated to significantly contribute to the development of personalized medicine. Currently, single-cell technology is less frequently utilized for prostate cancer compared with other types of tumors. Starting from the perspective of RNA sequencing technolog...
Source: Military Medical Research - April 11, 2024 Category: International Medicine & Public Health Source Type: research
FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
ConclusionsFOXO1high neutrophils represent a novel neutrophil phenotype that emerges in response to acute and chronic TBI, which provides insight into the heterogeneity, reprogramming activity, and versatility of neutrophils in TBI. (Source: Military Medical Research)
Source: Military Medical Research - March 31, 2024 Category: International Medicine & Public Health Source Type: research
Immune cells: potential carriers or agents for drug delivery to the central nervous system
AbstractDrug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous system (CNS) remains a challenge mainly due to the obstruction from brain barriers. Immune cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug delivery. Herein, we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood –brain barrier. We subsequently review biomimetic strategies ut...
Source: Military Medical Research - March 29, 2024 Category: International Medicine & Public Health Source Type: research
Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure
(Source: Military Medical Research)
Source: Military Medical Research - March 20, 2024 Category: International Medicine & Public Health Source Type: research
Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
ConclusionsOur data reveal that the KIF5B/EndoA2/Piezo2 complex is essential for Piezo2 trafficking and for sustaining transmission of touch and mechanical hypersensitivity signals. EndoA2 regulates touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking in sensory neurons. Our findings identify a potential new target for the treatment of mechanical pain. (Source: Military Medical Research)
Source: Military Medical Research - March 12, 2024 Category: International Medicine & Public Health Source Type: research
Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
ConclusionThis study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau accumulation. Notably, our novel findings regarding the efficacy of UA in reducing tau load and targeting the vCA1 microcircuit may provide a promising strategy for treating AD in the future. (Source: Military Medical Research)
Source: Military Medical Research - March 11, 2024 Category: International Medicine & Public Health Source Type: research
Emerging roles of ADP-dependent glucokinase in prostate cancer
(Source: Military Medical Research)
Source: Military Medical Research - February 27, 2024 Category: International Medicine & Public Health Source Type: research
CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD
ConclusionsThe intuitive nomogram constructed by CT-based whole-lung radiomic has shown good performance and high accuracy in identifying COPD in this multicenter study. (Source: Military Medical Research)
Source: Military Medical Research - February 20, 2024 Category: International Medicine & Public Health Source Type: research
Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration
AbstractScar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological function. Accumulating evidence underscores the potential of targeted modulation of mechanical cues to enhance skin regeneration, promoting scarless repair by influencing the extracellular microenvironment and driving the phenotypic transitions. The field of skin repair and skin appendage regeneration has witnessed remarkable advancements in the utilization of biomaterials with distinct physical properties. How...
Source: Military Medical Research - February 18, 2024 Category: International Medicine & Public Health Source Type: research
