Gastrointestinal dysfunction is associated with mortality in severe burn patients: a 10-year retrospective observational study from South China
ConclusionPatients with severe burns have an unfavourable prognosis, as nearly one-fifth died within 90 d. Half of our patients had comorbidities related to GI dysfunction, among which GI ulcers and haemorrhages were independently correlated with 90-day mortality. More attention should be given to severe burn patients with GI dysfunction. (Source: Military Medical Research)
Source: Military Medical Research - September 5, 2022 Category: International Medicine & Public Health Source Type: research
Masquelet technique in military practice: specificities and future directions for combat-related bone defect reconstruction
AbstractBecause of its simplicity, reliability, and replicability, the Masquelet induced membrane technique (IMT) has become one of the preferred methods for critical bone defect reconstruction in extremities. Although it is now used worldwide, few studies have been published about IMT in military practice. Bone reconstruction is particularly challenging in this context of care due to extensive soft-tissue injury, early wound infection, and even delayed management in austere conditions. Based on our clinical expertise, recent research, and a literature analysis, this narrative review provides an overview of the IMT applica...
Source: Military Medical Research - September 2, 2022 Category: International Medicine & Public Health Source Type: research
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles
ConclusionOur work showed that C3 and C4 are qualified candidates for the treatment of wear particle-induced osteolysis. (Source: Military Medical Research)
Source: Military Medical Research - August 23, 2022 Category: International Medicine & Public Health Source Type: research
Correction: Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
(Source: Military Medical Research)
Source: Military Medical Research - August 23, 2022 Category: International Medicine & Public Health Source Type: research
DPP-4 inhibitors and GLP-1RAs: cardiovascular safety and benefits
AbstractGlucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used treatments for patients with type 2 diabetes mellitus (T2DM). Both anti-diabetic treatments function by playing key modulatory roles in the incretin system. Though these drugs have been deemed effective in treating T2DM, the Food and Drug Administration (FDA) and some members of the scientific community have questioned the safety of these therapeutics relative to important cardiovascular endpoints. As a result, since 2008, the FDA has required all new drugs for glycemic control in T2DM patients to demonstrate cardiovas...
Source: Military Medical Research - August 20, 2022 Category: International Medicine & Public Health Source Type: research
Treatment and surveillance for non-muscle-invasive bladder cancer: a clinical practice guideline (2021 edition)
AbstractNon-muscle invasive bladder cancer (NMIBC) is a major type of bladder cancer with a high incidence worldwide, resulting in a great disease burden. Treatment and surveillance are the most important part of NIMBC management. In 2018, we issued “Treatment and surveillance for non-muscle-invasive bladder cancer in China: an evidence-based clinical practice guideline”. Since then, various studies on the treatment and surveillance of NMIBC have been published. There is a need to incorporate these materials and also to take into account th e relatively limited medical resources in primary medical institutions in China...
Source: Military Medical Research - August 17, 2022 Category: International Medicine & Public Health Source Type: research
Multifaceted roles of extracellular RNAs in different diseases
AbstractExtracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarkers. There has been immense work carried out since the discovery of exRNAs in circulation and other biological fluids to catalog and determine whether exRNAs may be utilized as indicators for health and illness. In this review, we aim to understand the current state of exRNAs in relation to various diseases and their potential as biomarkers. We will also review current issues and challenges faced in using exRNA...
Source: Military Medical Research - August 11, 2022 Category: International Medicine & Public Health Source Type: research
Early burn wound excision in mass casualty events
(Source: Military Medical Research)
Source: Military Medical Research - August 9, 2022 Category: International Medicine & Public Health Source Type: research
The minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing
(Source: Military Medical Research)
Source: Military Medical Research - July 16, 2022 Category: International Medicine & Public Health Source Type: research
The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer
AbstractOverexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15 –20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase kinase activity, and its overexpression is linked to poor prognosis and shorter progression-free survival (PFS) and overall survival (OS). Among various treatment options, HER2-targe ting monoclonal antibodies and tyrosine kinase inhibitors (TKIs) have mostly been applied in recent decades to treat HER2-positive (HER2+) breast cancer patients. Although positive clinical outcomes were documented in both advan...
Source: Military Medical Research - July 13, 2022 Category: International Medicine & Public Health Source Type: research
mRNA vaccine development for cholangiocarcinoma: a precise pipeline
AbstractCholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments, including immune checkpoint blockade therapy. The mRNA vaccine-based immunotherapeutic strategy has attracted much attention for various diseases, however, its application in CHOL is limited due to the thoughtlessness in the integration of vaccine design and patient selection. A recent study established an integrated path for identifying potent CHOL antigens for mRNA vaccine development and a precise stratification for identifying CHOL patients who can benefit from the mRN...
Source: Military Medical Research - July 12, 2022 Category: International Medicine & Public Health Source Type: research
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
ConclusionsOur findings reveal that AD-like tau accumulation inhibits autophagosome formation and induces autophagy deficits by activating the TIA1/amino acid/mTORC1 pathway, and thus this work reveals new insight into tau-associated neurodegeneration and provides evidence supporting the use of new therapeutic targets for AD treatment and that of related tauopathies. (Source: Military Medical Research)
Source: Military Medical Research - July 7, 2022 Category: International Medicine & Public Health Source Type: research
Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury
ConclusionsAbrupt dysregulation of intestinal homeostasis plays a critical role in the progression toward TCI-induced death. Oral administration of Asn plus IPA may serve as an effective regimen to restore intestinal functions and prolong the posttraumatic survival time. (Source: Military Medical Research)
Source: Military Medical Research - July 6, 2022 Category: International Medicine & Public Health Source Type: research
Lethal means and suicide prevention among military veterans
(Source: Military Medical Research)
Source: Military Medical Research - July 5, 2022 Category: International Medicine & Public Health Source Type: research
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences
AbstractThe literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac hypertrophy and protecting blood vessels through improving the function of endothelium. However, do these interventions work in the aged human hearts? Cardiac aging is accompanied by an increase in left ventricular hypertrophy, along with diastolic and systolic dysfunction. It also confers significant cardiovascular risks for both sexes. The incidence and prevalence of CVD increase sharply at an earlier age in...
Source: Military Medical Research - July 4, 2022 Category: International Medicine & Public Health Source Type: research
