Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D
(Source: Military Medical Research)
Source: Military Medical Research - February 8, 2024 Category: International Medicine & Public Health Source Type: research
In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy
(Source: Military Medical Research)
Source: Military Medical Research - February 3, 2024 Category: International Medicine & Public Health Source Type: research
Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways
(Source: Military Medical Research)
Source: Military Medical Research - February 1, 2024 Category: International Medicine & Public Health Source Type: research
Nickel ’s carcinogenicity: the need of more studies to progress
(Source: Military Medical Research)
Source: Military Medical Research - January 25, 2024 Category: International Medicine & Public Health Source Type: research
Antimicrobial resistance crisis: could artificial intelligence be the solution?
AbstractAntimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be developed. The discovery and introduction of novel antibiotics are time-consuming and expensive. According to WHO ’s report of antibacterial agents in clinical development, only 18 novel antibiotics have been approved since 2014. Therefore, novel antibiotics are critically needed. Artificial intelligence (AI) has been rapidly applied to drug development since its recent technical breakthrough and has dramatic a...
Source: Military Medical Research - January 23, 2024 Category: International Medicine & Public Health Source Type: research
Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations?
(Source: Military Medical Research)
Source: Military Medical Research - January 22, 2024 Category: International Medicine & Public Health Source Type: research
Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses
(Source: Military Medical Research)
Source: Military Medical Research - January 12, 2024 Category: International Medicine & Public Health Source Type: research
GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis
(Source: Military Medical Research)
Source: Military Medical Research - January 8, 2024 Category: International Medicine & Public Health Source Type: research
Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
ConclusionOur scaffold-based T-cell therapy presents an innovative in situ localized approach for programming T-cells to target solid tumors. This approach offers a viable alternative to in vitro manipulation of T-cells, circumventing the need for large-scale in vitro generation and culture of tumor-specific T-cells. It offers an off-the-shelf alternative that facilitates the use of host cells instead of allogeneic cells, thereby, overcoming a major hurdle. (Source: Military Medical Research)
Source: Military Medical Research - January 4, 2024 Category: International Medicine & Public Health Source Type: research
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
(Source: Military Medical Research)
Source: Military Medical Research - January 3, 2024 Category: International Medicine & Public Health Source Type: research
Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures
ConclusionWe conclude that disentangling GWI and PTSD by defining trauma-based subgroups may aid in the identification of unique GWI biosignatures that can help to improve diagnosis and target treatment of GWI more effectively. (Source: Military Medical Research)
Source: Military Medical Research - January 2, 2024 Category: International Medicine & Public Health Source Type: research
Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
ConclusionsFBXL6 activates KRAS or KRASG12D via ubiquitination at the site K128, leading to activation of the ERK/mTOR/PRELID2/ROS axis and tumorigenesis. Dual inhibition of MEK and mTOR effectively protects against FBXL6- and KRASG12D-induced tumorigenesis, providing a potential therapeutic strategy to treat this aggressive subtype of liver cancer. (Source: Military Medical Research)
Source: Military Medical Research - December 20, 2023 Category: International Medicine & Public Health Source Type: research
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
ConclusionsOur study identifies that megakaryocytic mitochondria-cGAS/STING-IFN- β-GBP2 axis serves as a fundamental checkpoint that instructs the size and function of platelets upon radiation injury and can be harnessed to treat platelet pathologies. (Source: Military Medical Research)
Source: Military Medical Research - December 19, 2023 Category: International Medicine & Public Health Source Type: research
The applied principles of EEG analysis methods in neuroscience and clinical neurology
This article reviews the types of EEG signals, multiple EEG signal analysis methods, and the application of relevant methods in the neuroscience field and for diagnosing neurological diseases. First, three types of EEG signals, including time-invariant EEG, accurate event-related EEG, and random event-related EEG, are introduced. Second, five main directions for the methods of EEG analysis, including power spectrum analysis, time –frequency analysis, connectivity analysis, source localization methods, and machine learning methods, are described in the main section, along with different sub-methods and effect evaluations ...
Source: Military Medical Research - December 19, 2023 Category: International Medicine & Public Health Source Type: research
Pre-hospital application of REBOA for life-threatening hemorrhage
(Source: Military Medical Research)
Source: Military Medical Research - December 13, 2023 Category: International Medicine & Public Health Source Type: research
