Surveillance of arthropod-borne viruses in Benin, West Africa 2020 –2021: detection of dengue virus 3 in Aedes aegypti (Diptera: Culicidae)
(Source: Military Medical Research)
Source: Military Medical Research - November 14, 2022 Category: International Medicine & Public Health Source Type: research
Introduction of monkeypox virus in Benin, 2022
(Source: Military Medical Research)
Source: Military Medical Research - November 9, 2022 Category: International Medicine & Public Health Source Type: research
Alterations in the human oral microbiome in cholangiocarcinoma
(Source: Military Medical Research)
Source: Military Medical Research - November 8, 2022 Category: International Medicine & Public Health Source Type: research
Extracellular vesicles in the pathogenesis and treatment of acute lung injury
AbstractAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening lung diseases associated with acute and severe inflammation. Both have high mortality rates, and despite decades of research on clinical ALI/ARDS, there are no effective therapeutic strategies. Disruption of alveolar-capillary barrier integrity or activation of inflammatory responses leads to lung inflammation and injury. Recently, studies on the role of extracellular vesicles (EVs) in regulating normal and pathophysiologic cell activities, including inflammation and injury responses, have attracted attention. Injured...
Source: Military Medical Research - November 1, 2022 Category: International Medicine & Public Health Source Type: research
Preemptive targeted muscle reinnervation: the single incision approach should be avoided in trans-tibial traumatic amputation
(Source: Military Medical Research)
Source: Military Medical Research - October 24, 2022 Category: International Medicine & Public Health Source Type: research
Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial
ConclusionThis study indicates that amisulpride augmentation therapy has important clinical significance for treating CTRS to improve clinical symptoms and cognitive function with tolerability and safety.Trial registration Clinicaltrials.gov identifier- NCT03652974. Registered August 31, 2018,https://clinicaltrials.gov/ct2/show/NCT03652974 (Source: Military Medical Research)
Source: Military Medical Research - October 18, 2022 Category: International Medicine & Public Health Source Type: research
Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias
ConclusionsI/R-induced cardiac PIASy activation increased Cav-3 SUMOylation by SUMO2/3 and dysregulated Nav1.5-related ventricular arrhythmias. Cardiac-targetedPIASy silencing mediated Cav-3 deSUMOylation and partially prevented I/R-induced Nav1.5 downregulation in the plasma membrane of cardiomyocytes, and subsequent ventricular arrhythmias in rats. PIASy was identified as a potential therapeutic target for life-threatening arrhythmias in patients with ischemic heart diseases. (Source: Military Medical Research)
Source: Military Medical Research - October 14, 2022 Category: International Medicine & Public Health Source Type: research
Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine
AbstractPancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity, especially in genetic alteration and microenvironment. Conventional therapeutic strategies for pancreatic cancer usually suffer resistance, highlighting the necessity for personalized precise treatment. Cancer vaccines have become promising alternatives for pancreatic cancer treatment because of their multifaceted advantages including multiple targeting, minimal nonspecific effects, broad therapeutic window, low toxicity, and induction of persistent immunological memory. Multiple conventional vaccines based on the cells, microorgan...
Source: Military Medical Research - October 13, 2022 Category: International Medicine & Public Health Source Type: research
Comparison of emergency surgical cricothyroidotomy and percutaneous cricothyroidotomy by experienced airway providers in an obese, in vivo porcine hemorrhage airway model
ConclusioneFONA by surgical cricothyroidotomy was faster and had increased oxygenation and survival, when performed under stress by board certified anesthesiologists, and may be an indication of preferred method in situations with hemorrhage and CICO, in obese patients. (Source: Military Medical Research)
Source: Military Medical Research - October 11, 2022 Category: International Medicine & Public Health Source Type: research
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
AbstractSepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is also one of the significant causes of death and increased health care costs in modern intensive care units. The use of antibiotics, fluid resuscitation, and organ support therapy have limited prognostic impact in patients with sepsis. Although its pathophysiology remains elusive, immunosuppression is now recognized as one of the major causes of septic death. Sepsis-induced immunosuppression is resulted from disruption of immune homeostasis. ...
Source: Military Medical Research - October 9, 2022 Category: International Medicine & Public Health Source Type: research
Monkeypox outbreak in the age of COVID-19: a new global health emergency
(Source: Military Medical Research)
Source: Military Medical Research - October 2, 2022 Category: International Medicine & Public Health Source Type: research
Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/ β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability
ConclusionsOur findings elucidate that melatonin mitigates the HDAC7/ β-catenin/c-Myc positive feedback loop and inhibits the USP10-maintained HDAC7 protein stability thus suppressing ESCC cell growth, and provides the reference for identifying biomarkers and therapeutic targets for ESCC. (Source: Military Medical Research)
Source: Military Medical Research - September 27, 2022 Category: International Medicine & Public Health Source Type: research
Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
AbstractThe advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour immune microenvironment (TIME). This review focuses on the application of scRNA-seq in investigation of the TIME. Over time, scRNA-seq methods have evolved, and components of the TIME have been deciphered with high resolution. In this review, we first introduced the principle of scRNA-seq and compared different sequencing approaches. Novel cell types in the TIME, a continuous transitional state, and mutual intercommunication among TIME components present potential targets for prognosis prediction and treatment in cancer. Thus,...
Source: Military Medical Research - September 26, 2022 Category: International Medicine & Public Health Source Type: research
An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening
ConclusionThis microfluidics-based “SMART” platform allows high-throughput single-cell capture and culture, dynamic drug-gradient treatment and cell response monitoring, which represents a new approach to efficiently investigate anticancer drug effects and should benefit drug discovery for leukemia and other cancers. (Source: Military Medical Research)
Source: Military Medical Research - September 22, 2022 Category: International Medicine & Public Health Source Type: research
The relationship between chronic PTSD, cortical volumetry and white matter microstructure among Australian combat veterans
ConclusionsFindings from this study reinforce reports of white matter alterations, as indicated by reduced fractional anisotropy values, in relation to PTSD symptom severity, as well as patterns of reduced volume in the prefrontal cortex. These results contribute to the developing profile of neuroanatomical differences uniquely attributable to veterans who suffer from chronic PTSD. (Source: Military Medical Research)
Source: Military Medical Research - September 16, 2022 Category: International Medicine & Public Health Source Type: research
