Acute kidney injury in severely injured patients admitted to the intensive care unit
ConclusionWe found that age, APACHE II score, thoracic trauma, lactic acidosis, and dobutamine administration were independently associated with AKI. Trauma surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients. (Source: Military Medical Research)
Source: Military Medical Research - October 9, 2020 Category: International Medicine & Public Health Source Type: research
Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study
We report the study protocol of a pilot study funded under the South-Central Mental Illness Research, Education, and Clinical Center pilot study program from the U.S. Department of Veterans Affairs. This randomized, open-label study was designed to evaluate the feasibility of completing a randomized trial of quetiapine vs. treatment as usual to promote patient engagement in PTSD patients with a history of mTBI.DiscussionWe expect that the success of this ongoing study should provide us with the preliminary data necessary to design a full-scale randomized trial. Positive efficacy results in a full- scale trial should inform...
Source: Military Medical Research - October 8, 2020 Category: International Medicine & Public Health Source Type: research
Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma
ConclusionWhen COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment, alternative therapy with convalescent plasma administration may be considered. (Source: Military Medical Research)
Source: Military Medical Research - September 22, 2020 Category: International Medicine & Public Health Source Type: research
Mental health status in veterans residing in rural versus non-rural areas: results from the veterans ’ health study
ConclusionsRural residence is associated with lower mental health service use, but not with poor mental health in veterans with former warzone deployment, suggesting rural residence is possibly protective. (Source: Military Medical Research)
Source: Military Medical Research - September 20, 2020 Category: International Medicine & Public Health Source Type: research
Creation of an optic nerve sheath diameter ultrasound model for NeuroICU education
ConclusionA simple 3D ballistic ONSD model allows learners to practice proper hand placement and pressure, basic landmarks, and ONSD measurement prior to operating on a human eye. This model is replicable and sustainable given that the globe and platform are composed of ballistics gel. (Source: Military Medical Research)
Source: Military Medical Research - September 20, 2020 Category: International Medicine & Public Health Source Type: research
Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules
ConclusionThe results of the present study demonstrated the feasibility of chemically converting human and mouse astrocytes into motor neuron-like cells that are useful for neurodegenerative disease modeling and regenerative medicine. (Source: Military Medical Research)
Source: Military Medical Research - September 5, 2020 Category: International Medicine & Public Health Source Type: research
Chemoprophylaxis, diagnosis, treatments, and discharge management of COVID-19: An evidence-based clinical practice guideline (updated version)
AbstractThe novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a rapidly spreading illness, coronavirus disease 2019 (COVID-19), affecting more than seventeen million people around the world. Diagnosis and treatment guidelines for clinicians caring for patients are needed. In the early stage, we have issued “A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version)”; now there are many direct evidences emerged and may change some of previous recommendations and it is ripe for develop an evidence-based guideline. W...
Source: Military Medical Research - September 3, 2020 Category: International Medicine & Public Health Source Type: research
Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis
ConclusionA total of 12 parameters – T, GCS, pH, Lac, PLT, PT, Fib, TnI, AST, TBIL, Cr and gastrointestinal AGI classification – are the EHSS parameters with the best effectiveness in evaluating the prognosis of EHS patients. As EHSS score increases, the mortality rate of EHS patients gradually increases. (Source: Military Medical Research)
Source: Military Medical Research - August 26, 2020 Category: International Medicine & Public Health Source Type: research
Circadian misalignment on submarines and other non-24-h environments – from research to application
AbstractCircadian clocks have important physiological and behavioral functions in humans and other organisms, which enable organisms to anticipate and respond to periodic environmental changes. Disturbances in circadian rhythms impair sleep, metabolism, and behavior. People with jet lag, night workers and shift workers are vulnerable to circadian misalignment. In addition, non-24-h cycles influence circadian rhythms and cause misalignment and disorders in different species, since these periods are beyond the entrainment ranges. In certain special conditions, e.g., on submarines and commercial ships, non-24-h watch sched...
Source: Military Medical Research - August 18, 2020 Category: International Medicine & Public Health Source Type: research
The impacts of infectious complications on outcomes in acute pancreatitis: a retrospective study
ConclusionClinicians should be aware that extrapancreatic infection (EPI) significantly aggravates the main outcome in pancreatic infection patients. Infection with MDR bacteria is also associated with AP mortality. (Source: Military Medical Research)
Source: Military Medical Research - August 15, 2020 Category: International Medicine & Public Health Source Type: research
Interpretations and comments for expert consensus on the diagnosis and treatment of heat stroke in China
This article aims to interpret and supplement the major updates to the new consensus. (Source: Military Medical Research)
Source: Military Medical Research - August 5, 2020 Category: International Medicine & Public Health Source Type: research
Comparison of clinical laboratory tests between bacterial sepsis and SARS-CoV-2-associated viral sepsis
AbstractSepsis is a life-threatening condition that is characterized by multiple organ dysfunction due to abnormal host response to various pathogens, like bacteria, fungi and virus. The differences between viral and bacterial sepsis are indeed of great significance to deepen the understanding of the pathogenesis of sepsis, especially under pandemics of SARS-CoV-2 infection. (Source: Military Medical Research)
Source: Military Medical Research - August 3, 2020 Category: International Medicine & Public Health Source Type: research
EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study
ConclusionsUnder the latest LLSS, we find thatEPAS1 andVEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population; this tool might be useful for screening susceptible populations and predicting clinical symptoms leading to AMS before an individual reaches HA.Trial registrationChinese Clinical Trial Registration,ChiCTR-RCS-12002232. Registered 31 May 2012. (Source: Military Medical Research)
Source: Military Medical Research - July 26, 2020 Category: International Medicine & Public Health Source Type: research
Meta-analysis of the success rate of heartbeat recovery in patients with prehospital cardiac arrest in the past 40 years in China
Conclusions(1) The HRR is time-sensitive, and early rescue can improve it. (2) CPR performed within the platinum ten minutes must be executed by the public, and other forces are auxiliary. (3) The concept of peri-cardiac arrest period (PCAP) should be established and improved to guide CPR. (Source: Military Medical Research)
Source: Military Medical Research - July 6, 2020 Category: International Medicine & Public Health Source Type: research
Validation of the age-adjusted shock index for pediatric casualties in Iraq and Afghanistan
ConclusionsWithin the combat setting, the age-adjusted pediatric shock index had moderate sensitivity and relatively poor specificity for predicting massive transfusion and death. Better scoring systems are needed to predict resource needs prior to arrival, that perhaps include other physiologic metrics. We were unable to validate the previously published findings within the combat trauma population. (Source: Military Medical Research)
Source: Military Medical Research - July 1, 2020 Category: International Medicine & Public Health Source Type: research
