Potential roles of vitamin D binding protein in attenuating liver injury in sepsis
ConclusionVDBP may be protective against sepsis-induced liver injury. (Source: Military Medical Research)
Source: Military Medical Research - January 20, 2022 Category: International Medicine & Public Health Source Type: research
Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
AbstractBacteria can evolve rapidly by acquiring new traits such as virulence, metabolic properties, and most importantly, antimicrobial resistance, through horizontal gene transfer (HGT). Multidrug resistance in bacteria, especially in Gram-negative organisms, has become a global public health threat often through the spread of mobile genetic elements. Conjugation represents a major form of HGT and involves the transfer of DNA from a donor bacterium to a recipient by direct contact. Conjugative plasmids, a major vehicle for the dissemination of antimicrobial resistance, are selfish elements capable of mediating their own ...
Source: Military Medical Research - January 10, 2022 Category: International Medicine & Public Health Source Type: research
Military traumatic brain injury: a challenge straddling neurology and psychiatry
AbstractMilitary psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiological data, neuropathology, and the research achievements of diagnosis and treatment technology, and discussing its comorbidity and sequelae. To date, advances in neuroimaging and molecular biology have greatly boosted the studies on military traumatic brain injury (TBI). In particular, in terms of pathophysiological mechanisms, several preclinical studies have identified abnormal protein accumulation, blood â...
Source: Military Medical Research - January 6, 2022 Category: International Medicine & Public Health Source Type: research
Autologous omentum transposition for regeneration of a renal injury model in rats
ConclusionAutologous omentum tissue for kidney injury repair attenuated inflammation and granulation. Additionally, the use of omental tissue to facilitate healing of kidney injury may theoretically lead to a more effective healing process and reduced fibrosis and tissue and function loss. (Source: Military Medical Research)
Source: Military Medical Research - January 4, 2022 Category: International Medicine & Public Health Source Type: research
Cell fusion in the pathogenesis of COVID-19
(Source: Military Medical Research)
Source: Military Medical Research - December 20, 2021 Category: International Medicine & Public Health Source Type: research
Advances in the design and development of SARS-CoV-2 vaccines
AbstractSince the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious and prone to rapid mutation, encodes both structural and nonstructural proteins. Vaccination is currently the only effective method to prevent COVID-19, and structural proteins are critical targets for vaccine development. Currently, many vaccines are in clinical trials or are already on the market. This review highlights ongoing advances in the design of prophylactic or therapeutic vaccines against COVID-19, ...
Source: Military Medical Research - December 16, 2021 Category: International Medicine & Public Health Source Type: research
Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model
ConclusionThis study suggested that melatonin could protect CBSCs against Îł-ray radiation and assist in the healing of postradiation bone defects. (Source: Military Medical Research)
Source: Military Medical Research - December 12, 2021 Category: International Medicine & Public Health Source Type: research
Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model
ConclusionsThis is the qualitative systematic review of studies on risk factors for MSkIs in the military that has attempted to be all-inclusive. A total of 57 different potential risk factors were identified, and a new, prioritizing injury model was developed. This model may help us to understand risk factors that can be addressed, and in which order they should be prioritized when planning intervention strategies within military groups. (Source: Military Medical Research)
Source: Military Medical Research - December 10, 2021 Category: International Medicine & Public Health Source Type: research
Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019
ConclusionOver the past three decades, the disease burden has increased for UTI but decreased for urolithiasis and BPH. The allocation of medical resources should be based more on the epidemiological characteristics and geographical distribution of diseases. (Source: Military Medical Research)
Source: Military Medical Research - December 9, 2021 Category: International Medicine & Public Health Source Type: research
Estimation of radiation-induced health hazards from a “dirty bomb” attack with radiocesium under different assault and rescue conditions
AbstractIn the case of a terrorist attack by a “dirty bomb”, blast injuries, external irradiation and the incorporation of radioactivity are to be expected. Departing from information about the radiological attack scenario with cesium-137 in the U.S. National Scenario Planning Guide, we estimated the radiological doses absorbed. Similar calc ulations were performed for a smaller plume size and a detonation in a subway. For conditions as described in the U.S. scenario, the committed effective dose amounted to a maximum of 848 mSv, even for very unfavorable conditions. Red bone marrow equivalent doses are insufficient t...
Source: Military Medical Research - December 9, 2021 Category: International Medicine & Public Health Source Type: research
Excellent effects and possible mechanisms of action of a new antibody –drug conjugate against EGFR-positive triple-negative breast cancer
ConclusionsLR004-VC-MMAE showed effective antitumor activity by inhibiting the activation of EGFR signaling and the expression of cancer stemness marker genes. It might be a promising therapeutic candidate and provides a potential therapeutic avenue for the treatment of EGFR-positive TNBC. (Source: Military Medical Research)
Source: Military Medical Research - December 9, 2021 Category: International Medicine & Public Health Source Type: research
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood –brain barrier injury through the Wnt/β-catenin signalling pathway
ConclusionThis study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/ β-catenin signalling pathway under ischemic conditions. (Source: Military Medical Research)
Source: Military Medical Research - December 3, 2021 Category: International Medicine & Public Health Source Type: research
Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990 –2019
ConclusionsKidney, bladder, and prostate cancers remain major global public health challenges, but with distinct trend for different disease entity across different regions and socioeconomic status. More proactive intervention strategies, at both the administrative and academic levels, based on the dynamic changes, are needed. (Source: Military Medical Research)
Source: Military Medical Research - November 24, 2021 Category: International Medicine & Public Health Source Type: research
Regional trauma system development in Shenzhen, China: an 8-year journey
(Source: Military Medical Research)
Source: Military Medical Research - November 13, 2021 Category: International Medicine & Public Health Source Type: research
Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
ConclusionIt is concluded that propofol postconditioning attenuated H9c2 cardiac cells apoptosis and autophagy induced by H/R injury through upregulating FoxO1 and FoxO3a under hyperglycemia. (Source: Military Medical Research)
Source: Military Medical Research - November 10, 2021 Category: International Medicine & Public Health Source Type: research
