TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
(Source: Military Medical Research)
Source: Military Medical Research - June 22, 2022 Category: International Medicine & Public Health Source Type: research
Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
(Source: Military Medical Research)
Source: Military Medical Research - June 21, 2022 Category: International Medicine & Public Health Source Type: research
Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up
ConclusionsThis study is the first to characterize the oral and gut microbiome and metabonomics in 1-year convalescents of COVID-19. The key microbiome and metabolites in the process of recovery were identified, and provided new treatment ideas for accelerating recovery. And the predictive models based on the microbiome and metabolomics afford new insights for predicting the recovery situation which benefited affected individuals and healthcare. (Source: Military Medical Research)
Source: Military Medical Research - June 17, 2022 Category: International Medicine & Public Health Source Type: research
An unfolding monkeypox outbreak in Europe and beyond
(Source: Military Medical Research)
Source: Military Medical Research - June 15, 2022 Category: International Medicine & Public Health Source Type: research
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
ConclusionsWe found that CQ could disrupt glycolysis and energy metabolism of malarial parasites through direct binding with some of the key enzymes, a new mechanism that is different from its well-known inhibitory effect of hemozoin formation. This is the first report of identifying CQ antimalarial targets by a parallel usage of labeled (ABPP) and label-free (MS-CETSA) methods. (Source: Military Medical Research)
Source: Military Medical Research - June 14, 2022 Category: International Medicine & Public Health Source Type: research
Monkeypox outbreak: A novel threat after COVID-19?
(Source: Military Medical Research)
Source: Military Medical Research - June 13, 2022 Category: International Medicine & Public Health Source Type: research
Pushing the frontiers of military medical excellence: updates, progress and future needs
AbstractSince its establishment in 2014,MilitaryMedicalResearch has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with military relevance. The field of military medicine may be obscure, and may not be readily encountered by the typical clinician on a day-to-day basis. This journal aims not only to pursue excellence in military research, but also keep current with the latest advancements on general medical topics from each and every specialty. This editorial serves to recap and synthesize the existing progress, updates and future n...
Source: Military Medical Research - June 10, 2022 Category: International Medicine & Public Health Source Type: research
Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives
AbstractGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutation, as well as the presence of the blood –brain barrier (BBB), have reduced the efficacy of GBM treatment. The emergence of a novel therapeutic method, namely, sonodynamic therapy (SDT), provides a promising strategy for eradicating tumors via activated sonosensitizers coupled with low-intensity ultrasound. SDT can provide tumor killing effects for deep-seated tumors, such as brain tumors. However, conventi...
Source: Military Medical Research - June 9, 2022 Category: International Medicine & Public Health Source Type: research
Molecular diagnostic approaches for enteric parasites: an issue of relevance for deployed soldiers?
(Source: Military Medical Research)
Source: Military Medical Research - June 9, 2022 Category: International Medicine & Public Health Source Type: research
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis
ConclusionsCIRI activated Drp1 and accelerated the p62-mediated formation of autophagosomes while inhibiting the transition of autophagosomes to autolysosomes via the RIP1/RIP3 pathway activation. Undegraded autophagosomes were secreted extracellularly in the form of exosomes, leading to inflammatory cascades that further damaged mitochondria, resulting in excessive ROS generation and the blockage of autophagosome degradation, triggering a vicious cycle. (Source: Military Medical Research)
Source: Military Medical Research - May 27, 2022 Category: International Medicine & Public Health Source Type: research
Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients
ConclusionsActivation-induced MAIT cell pyroptosis contributes to the loss of MAIT cells in HIV-1 infected patients, which could potentiate disease progression and poor immune reconstitution. (Source: Military Medical Research)
Source: Military Medical Research - May 27, 2022 Category: International Medicine & Public Health Source Type: research
Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy
ConclusionRisa could inhibit autophagy by regulating the Sirt1/GSK3 β axis, thereby aggravating podocyte injury in DN.Risa may serve as a therapeutic target for the treatment of DN. (Source: Military Medical Research)
Source: Military Medical Research - May 26, 2022 Category: International Medicine & Public Health Source Type: research
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
ConclusionCel inhibits inflammation and the Warburg effect in sepsis via targeting PKM2 and HMGB1 protein. (Source: Military Medical Research)
Source: Military Medical Research - May 20, 2022 Category: International Medicine & Public Health Source Type: research
Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
AbstractIdiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lung function. Chronic inflammation has been demonstrated to be the pathological basis of fibrosis. Emerging studies have revealed that most interleukin-17 (IL-17) isoforms are essential for the mediation of acute and chronic inflammation via innate and adaptive immunity. Overexpression or aberrant expression of IL-17 cytokines contributes to various pathological outcomes, including the initiation and exacerbatio...
Source: Military Medical Research - May 12, 2022 Category: International Medicine & Public Health Source Type: research
Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology. The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidence-based consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. (Source: Military Medical Research)
Source: Military Medical Research - April 26, 2022 Category: International Medicine & Public Health Source Type: research
