Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine
AbstractIntegrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. Integrated TCM and WM has a long history in China, and has made important achievements in the process of clinical diagnosis and treatment. However, the methodological defects in currently published clinical practice guidelines limit its development. The organic integration of TCM and WM is a deeper integration of TCM and WM. To realize the progression of"integration" to"organic integration", ...
Source: Military Medical Research - September 27, 2023 Category: International Medicine & Public Health Source Type: research
Deep learning-based lung sound analysis for intelligent stethoscope
AbstractAuscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot record respiratory sounds for offline/retrospective diagnosis or remote prescriptions in telemedicine. The emergence of digital stethoscopes has overcome these limitations by allowing physicians to store and share respiratory sounds for consultation and education. On this basis, machine learning, particularly deep learning, enables the fully-automatic analysis of lung sounds that may pave the way for intelligent st...
Source: Military Medical Research - September 26, 2023 Category: International Medicine & Public Health Source Type: research
Enhancing the clinical relevance of haemorrhage prediction models in trauma
(Source: Military Medical Research)
Source: Military Medical Research - September 20, 2023 Category: International Medicine & Public Health Source Type: research
RARRES2 ’s impact on lipid metabolism in triple-negative breast cancer: a pathway to brain metastasis
(Source: Military Medical Research)
Source: Military Medical Research - September 12, 2023 Category: International Medicine & Public Health Source Type: research
Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities
ConclusionsShort-term heat exposure may increase the risk of hospitalization for CKD. Our findings provide insights into the health effects of climate change and suggest the necessity of guided protection strategies against the adverse effects of high temperatures. (Source: Military Medical Research)
Source: Military Medical Research - September 5, 2023 Category: International Medicine & Public Health Source Type: research
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
AbstractThe treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity, good drug-loading ability and sustained drug release properties. As a typical example, hyaluronic acid dressing (Healoderm) has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ulcers. However, the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted accord...
Source: Military Medical Research - August 23, 2023 Category: International Medicine & Public Health Source Type: research
Bioengineered skin organoids: from development to applications
AbstractSignificant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into complex structures and are increasingly recognized as effective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional systems and ethical concerns. The inherent plasticity of skin organoids allows for their construction into physiological and pathological models, enabling the study of skin development and dynamic changes. This review provid...
Source: Military Medical Research - August 22, 2023 Category: International Medicine & Public Health Source Type: research
Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer
(Source: Military Medical Research)
Source: Military Medical Research - August 18, 2023 Category: International Medicine & Public Health Source Type: research
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges
In conclusion, MSC-derived EVs-based therapies have important application prospects in wound repair. Here we provide a comprehensive overview of their current status, application potential, and associated drawbacks. (Source: Military Medical Research)
Source: Military Medical Research - August 17, 2023 Category: International Medicine & Public Health Source Type: research
Spatial transcriptomics: recent developments and insights in respiratory research
AbstractThe respiratory system ’s complex cellular heterogeneity presents unique challenges to researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) have provided insights into cell types and heterogeneity in the respiratory system, the relevant specific spatial localization and cell ular interactions have not been clearly elucidated. Spatial transcriptomics (ST) has filled this gap and has been widely used in respiratory studies. This review focuses on the latest iterative technology of ST in recent years, summarizing how ST can be applied to the physiological and pathologica...
Source: Military Medical Research - August 17, 2023 Category: International Medicine & Public Health Source Type: research
The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine
ConclusionThe piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops. (Source: Military Medical Research)
Source: Military Medical Research - July 31, 2023 Category: International Medicine & Public Health Source Type: research
RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
ConclusionsOur work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of BrM. RARRES2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM. (Source: Military Medical Research)
Source: Military Medical Research - July 25, 2023 Category: International Medicine & Public Health Source Type: research
China stroke surveillance report 2021
AbstractSince 2015, stroke has become the leading cause of death and disability in China, posing a significant threat to the health of its citizens as a major chronic non-communicable disease. According to the China Stroke High-risk Population Screening and Intervention Program, an estimated 17.8 million [95% confidence interval (CI) 17.6 –18.0 million] adults in China had experienced a stroke in 2020, with 3.4 million (95% CI 3.3–3.5 million) experiencing their first-ever stroke and another 2.3 million (95% CI 2.2–2.4 million) dying as a result. Additionally, approximately 12.5% (95% CI 12.4–12.5%) of stroke survi...
Source: Military Medical Research - July 19, 2023 Category: International Medicine & Public Health Source Type: research
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
This study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer therapy. Furthermore, we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them. (Source: Military Medical Research)
Source: Military Medical Research - July 17, 2023 Category: International Medicine & Public Health Source Type: research
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adversely affecting locomotion ability and life quality. Consequently, good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA. Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging. Herein, we review the fluorescent probes developed for the detection and imaging of RA biomarkers, namely reactive ...
Source: Military Medical Research - July 14, 2023 Category: International Medicine & Public Health Source Type: research
