Correction to: Nanomedicine ‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
(Source: Military Medical Research)
Source: Military Medical Research - January 25, 2023 Category: International Medicine & Public Health Source Type: research
Explosive eye injuries: characteristics, traumatic mechanisms, and prognostic factors for poor visual outcomes
ConclusionsExplosion ocular trauma has complex mechanisms, with multiple eyes involved and poor prognosis. In lethal level I explosion injuries, eyeball rupture is a serious condition, whereas contusion is more likely to improve. In level II injuries, IOFBs are more harmful than penetrating injuries, and level IV represents burn-related eye injuries. PVR is more associated with penetrating mechanisms than with OGI. Identifying the risk predictors for visual prognosis can guide clinicians in the evaluation and treatment of ocular blast injuries. (Source: Military Medical Research)
Source: Military Medical Research - January 12, 2023 Category: International Medicine & Public Health Source Type: research
Self-reported physical functioning, cardiometabolic health conditions, and health care utilization patterns in Million Veteran Program enrollees with Traumatic Brain Injury Screening and Evaluation Program data
ConclusionsThe findings suggest that veterans who screen positive for TBI, regardless of whether they are ultimately diagnosed with TBI, are at greater risk for negative health outcomes, signifying that these veterans represent a vulnerable group that may benefit from increased clinical care and prevention efforts. (Source: Military Medical Research)
Source: Military Medical Research - January 3, 2023 Category: International Medicine & Public Health Source Type: research
Adipose tissue macrophages: implications for obesity-associated cancer
AbstractObesity is one of the most serious global health problems, with an incidence that increases yearly and coincides with the development of cancer. Adipose tissue macrophages (ATMs) are particularly important in this context and contribute to linking obesity-related inflammation and tumor progression. However, the functions of ATMs on the progression of obesity-associated cancer remain unclear. In this review, we describe the origins, phenotypes, and functions of ATMs. Subsequently, we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment, including the direct excha...
Source: Military Medical Research - January 3, 2023 Category: International Medicine & Public Health Source Type: research
Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression
AbstractEmerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was developed. Literature related to the immune monitoring and treatment of sepsis were retrieved from PubMed, Web of Science, and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online questionnaire. Then, the Delphi method was used to form consensus opinions, and RAND appropri...
Source: Military Medical Research - December 26, 2022 Category: International Medicine & Public Health Source Type: research
Correction to: Pushing the frontiers of military medical excellence: updates, progress and future needs
(Source: Military Medical Research)
Source: Military Medical Research - December 23, 2022 Category: International Medicine & Public Health Source Type: research
Neuroinflammation in mild respiratory COVID-19: insights into cognitive impairment in milder cases
(Source: Military Medical Research)
Source: Military Medical Research - December 20, 2022 Category: International Medicine & Public Health Source Type: research
Expression dynamics of periodic transcripts during cancer cell cycle progression and their correlation with anticancer drug sensitivity
ConclusionsIn summary, we identified a panel of cell cycle-related periodic transcripts and found that the levels of transcripts of drug target genes showed different values for predicting drug sensitivity, providing novel insights into alternative splicing-related drug development and evaluation. (Source: Military Medical Research)
Source: Military Medical Research - December 19, 2022 Category: International Medicine & Public Health Source Type: research
A review on cell damage, viability, and functionality during 3D bioprinting
AbstractThree-dimensional (3D) bioprinting fabricates 3D functional tissues/organs by accurately depositing the bioink composed of the biological materials and living cells. Even though 3D bioprinting techniques have experienced significant advancement over the past decades, it remains challenging for 3D bioprinting to artificially fabricate functional tissues/organs with high post-printing cell viability and functionality since cells endure various types of stress during the bioprinting process. Generally, cell viability which is affected by several factors including the stress and the environmental factors, such as pH an...
Source: Military Medical Research - December 16, 2022 Category: International Medicine & Public Health Source Type: research
Nanomedicine ‐boosting icaritin-based immunotherapy of advanced hepatocellular carcinoma
AbstractTraditional treatments for advanced hepatocellular carcinoma (HCC), such as surgical resection, transplantation, radiofrequency ablation, and chemotherapy are unsatisfactory, and therefore the exploration of powerful therapeutic strategies is urgently needed. Immunotherapy has emerged as a promising strategy for advanced HCC treatment due to its minimal side effects and long-lasting therapeutic memory effects. Recent studies have demonstrated that icaritin could serve as an immunomodulator for effective immunotherapy of advanced HCC. Encouragingly, in 2022, icaritin soft capsules were approved by the National Medic...
Source: Military Medical Research - December 12, 2022 Category: International Medicine & Public Health Source Type: research
Treating traumatic brain injury at sea: how to improve the skills and capabilities of the naval medical personnel
(Source: Military Medical Research)
Source: Military Medical Research - December 5, 2022 Category: International Medicine & Public Health Source Type: research
Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications
AbstractThe application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic strategies. With the expansion of capacity for high-throughput scRNA-seq, including clinical samples, the analysis of these huge volumes of data has become a daunting prospect for researchers entering this field. Here, we review the workflow for typical scRNA-seq data analysis, covering raw data processing and quality control, basic data analysis applicable for almost all scRNA-seq data sets, and advanced dat...
Source: Military Medical Research - December 2, 2022 Category: International Medicine & Public Health Source Type: research
Enzymatic debridement shall not modify the global strategy for mass burn events
(Source: Military Medical Research)
Source: Military Medical Research - November 26, 2022 Category: International Medicine & Public Health Source Type: research
The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
AbstractBone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone, cartilage, and soft tissue regeneration, effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone, cartilage, and soft tissue regeneration; therefore, an in-depth understanding of the...
Source: Military Medical Research - November 19, 2022 Category: International Medicine & Public Health Source Type: research
Surveillance of arthropod-borne viruses in Benin, West Africa 2020 –2021: detection of dengue virus 3 in Aedes aegypti (Diptera: Culicidae)
(Source: Military Medical Research)
Source: Military Medical Research - November 14, 2022 Category: International Medicine & Public Health Source Type: research
