N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance
ConclusionsCENPK was shown to have an oncogenic role in cervical cancer and can thus serve as a prognostic indicator and novel target for cervical cancer treatment. (Source: Military Medical Research)
Source: Military Medical Research - April 14, 2022 Category: International Medicine & Public Health Source Type: research
Veterans utilizing a federally qualified health center: a clinical snapshot
(Source: Military Medical Research)
Source: Military Medical Research - April 13, 2022 Category: International Medicine & Public Health Source Type: research
Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury
AbstractSpinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of this disease still faces a huge challenge. Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord. Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneratio...
Source: Military Medical Research - April 12, 2022 Category: International Medicine & Public Health Source Type: research
Supraglottic jet oxygenation and ventilation (SJOV) for resuscitation of injured soldiers and people in war field
(Source: Military Medical Research)
Source: Military Medical Research - April 12, 2022 Category: International Medicine & Public Health Source Type: research
Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data
ConclusionThe proposed nodal staging strategy was successfully validated in large multi-ethnic GC datasets and represents a practical approach for homogenizing the classification of GC cohorts comprising of patients with < 16 and ≥ 16 rLNs. (Source: Military Medical Research)
Source: Military Medical Research - April 7, 2022 Category: International Medicine & Public Health Source Type: research
Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)
AbstractBenign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Transurethral plasmakinetic resection of prostate (TUPKP) is one of the foremost surgical procedures for the treatment of BPH. It has become well established in clinical practice with good efficacy and safety. In 2018, we issued the guideline “2018 Standard Edition”. However much new direct evidence has now emerged and this may change some of previous recommendations. The time is ripe to develop new evidence...
Source: Military Medical Research - April 1, 2022 Category: International Medicine & Public Health Source Type: research
Small molecules facilitate single factor-mediated sweat gland cell reprogramming
ConclusionWe developed a SG reprogramming strategy to generate functional iSGCs from HDFs by using the single factor EDA in combination with SGM and small molecules. The generation of iSGCs has important implications for future in situ skin regeneration with SG restoration. (Source: Military Medical Research)
Source: Military Medical Research - March 29, 2022 Category: International Medicine & Public Health Source Type: research
Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats
ConclusionOur findings suggested an association between the gut microbiota and BPH, but the causal relationship between the two groups is unclear. Thus, further studies are warranted to elucidate the potential mechanisms and causal relationships between BPH and gut microbiota. (Source: Military Medical Research)
Source: Military Medical Research - March 28, 2022 Category: International Medicine & Public Health Source Type: research
Microfluidics-based strategies for molecular diagnostics of infectious diseases
AbstractTraditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing (POCT). Emerging microfluidics, a highly miniaturized, automatic, and integrated technology, are a potential substitute for traditional methods in performing rapid, low-cost, accurate, and on-site diagnoses. Molecular diagnostics are widely used in microfluidic devices as the most effective approaches for pathogen detection. This review summarizes the latest advances in microfluidics-based molecular diagnostics for infectious diseases from academic perspectives and industr...
Source: Military Medical Research - March 18, 2022 Category: International Medicine & Public Health Source Type: research
Advances in electrical impedance tomography-based brain imaging
AbstractNovel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography (EIT) is a functional imaging technique that measures the transfer impedances between electrodes on the body surface to estimate the spatial distribution of electrical properties of tissues. EIT offers many advantages over other neuroimaging technologies, which has led to its potential clinical use. This qualitative review provides an overview of the basic principles, algorithms, and system composition of EIT. Re...
Source: Military Medical Research - February 28, 2022 Category: International Medicine & Public Health Source Type: research
Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo
ConclusionUTMD enhanced the radiosensitivity of glioblastoma partially by disrupting PGRMC1-mediated autophagy. (Source: Military Medical Research)
Source: Military Medical Research - February 14, 2022 Category: International Medicine & Public Health Source Type: research
Wave-shaped microfluidic chip assisted point-of-care testing for accurate and rapid diagnosis of infections
ConclusionsWMC-MDP allows simultaneous, rapid, and sensitive detection of CRP, PCT, and IL-6 with satisfactory selectivity and repeatability, requiring minimal manipulation. However, WMC-MDP takes advantage of being a microfluidic device showing the coefficients of variation less than 10% enabling WMC-MDP to be a type of point-of-care testing (POCT). Therefore, WMC-MDP provides a promising alternative to POCT of multiple biomarkers. We believe the practical application of WMC-MDP in militarized fields will revolutionize infection diagnosis for soldiers. (Source: Military Medical Research)
Source: Military Medical Research - February 11, 2022 Category: International Medicine & Public Health Source Type: research
Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer
(Source: Military Medical Research)
Source: Military Medical Research - February 4, 2022 Category: International Medicine & Public Health Source Type: research
FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF- κB pathway in airway epithelial cells
ConclusionOur findings suggest that FGF2 is a potential inflammatory modulator in asthma, which can be induced by HDM and acts through the FGFR/MAPK/NF- κB pathway in the airway epithelial cells. (Source: Military Medical Research)
Source: Military Medical Research - January 29, 2022 Category: International Medicine & Public Health Source Type: research
Early prostate specific antigen decline and its velocity are independent predictive factors for outcomes of mCRPC patients treated with abiraterone acetate
(Source: Military Medical Research)
Source: Military Medical Research - January 24, 2022 Category: International Medicine & Public Health Source Type: research
