RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
ConclusionsOur work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of BrM. RARRES2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM. (Source: Military Medical Research)
Source: Military Medical Research - July 25, 2023 Category: International Medicine & Public Health Source Type: research
China stroke surveillance report 2021
AbstractSince 2015, stroke has become the leading cause of death and disability in China, posing a significant threat to the health of its citizens as a major chronic non-communicable disease. According to the China Stroke High-risk Population Screening and Intervention Program, an estimated 17.8 million [95% confidence interval (CI) 17.6 –18.0 million] adults in China had experienced a stroke in 2020, with 3.4 million (95% CI 3.3–3.5 million) experiencing their first-ever stroke and another 2.3 million (95% CI 2.2–2.4 million) dying as a result. Additionally, approximately 12.5% (95% CI 12.4–12.5%) of stroke survi...
Source: Military Medical Research - July 19, 2023 Category: International Medicine & Public Health Source Type: research
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
This study aims to highlight the cutting-edge approaches in cancer-gene editing therapy based on the CRISPR/Cas technology to target miRNAs in cancer therapy. Furthermore, we highlight the potential challenges in CRISPR/Cas-mediated miRNA gene editing and offer advanced strategies to overcome them. (Source: Military Medical Research)
Source: Military Medical Research - July 17, 2023 Category: International Medicine & Public Health Source Type: research
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adversely affecting locomotion ability and life quality. Consequently, good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA. Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging. Herein, we review the fluorescent probes developed for the detection and imaging of RA biomarkers, namely reactive ...
Source: Military Medical Research - July 14, 2023 Category: International Medicine & Public Health Source Type: research
Correction to: Bioengineered materials with selective antimicrobial toxicity in biomedicine
(Source: Military Medical Research)
Source: Military Medical Research - July 12, 2023 Category: International Medicine & Public Health Source Type: research
What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments?
AbstractThe present study aimed to explore the potential of artificial intelligence (AI) methodology based on magnetic resonance (MR) images to aid in the management of prostate cancer (PCa). To this end, we reviewed and summarized the studies comparing the diagnostic and predictive performance for PCa between AI and common clinical assessment methods based on MR images and/or clinical characteristics, thereby investigating whether AI methods are generally superior to common clinical assessment methods for the diagnosis and prediction fields of PCa. First, we found that, in the included studies of the present study, AI met...
Source: Military Medical Research - June 26, 2023 Category: International Medicine & Public Health Source Type: research
Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis
(Source: Military Medical Research)
Source: Military Medical Research - June 25, 2023 Category: International Medicine & Public Health Source Type: research
Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
ConclusionsThis study identifiesHLA-DRlowS100Ahigh monocytes correlated with immunosuppressive state upon septic challenge, inhibition of which can markedly mitigate sepsis-induced immune depression, thereby providing a novel therapeutic strategy for the management of sepsis. (Source: Military Medical Research)
Source: Military Medical Research - June 19, 2023 Category: International Medicine & Public Health Source Type: research
A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities
AbstractSpinal cord injury (SCI) is a devastating and disabling medical condition generally caused by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological mechanisms directed to ameliorate neural damage but also exacerbate initial damage (secondary injury). The alterations that occur in the spinal cord have not only local but also systemic consequences and virtually all organs and tissues of the body incur important changes after SCI, explaining the progression and detrimental consequences related to this condition. Psychoneuroimmunoendocrinology (PNIE) is a growing area of research...
Source: Military Medical Research - June 9, 2023 Category: International Medicine & Public Health Source Type: research
Aspartoacylase suppresses prostate cancer progression by blocking LYN activation
ConclusionOur findings provide novel insights into the tumor-suppressive function of ASPA in PCa and highlight its potential as a prognostic biomarker and therapeutic target for the management of this malignancy. (Source: Military Medical Research)
Source: Military Medical Research - June 5, 2023 Category: International Medicine & Public Health Source Type: research
Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis
ConclusionsThis study presents a promising precision medicine approach to evaluate treatment response, which has the potential to aid clinicians in making informed decisions about APD treatment for patients with SCZ.Trial registration Chinese Clinical Trial Registry (https://www.chictr.org.cn/), 18. Aug 2009 retrospectively registered: CAPOC —ChiCTR-RNC-09000521 (https://www.chictr.org.cn/showproj.aspx?proj=9014), CAPEC —ChiCTR-RNC-09000522 (https://www.chictr.org.cn/showproj.aspx?proj=9013). (Source: Military Medical Research)
Source: Military Medical Research - June 2, 2023 Category: International Medicine & Public Health Source Type: research
Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus
AbstractContinuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal circulation during CRRT. Regional citrate anticoagulation (RCA) has been shown to potentially be safer and more effective and is now recommended as the preferred anticoagulant method for CRRT. However, there is still a lack of unified standards for RCA management in the world, and there are many problems in using this method in clinical practice. The Emergency Medical Doctor Branch of the Chinese Medical Doctor...
Source: Military Medical Research - May 29, 2023 Category: International Medicine & Public Health Source Type: research
Artificial intelligence-driven radiomics study in cancer: the role of feature engineering and modeling
AbstractModern medicine is reliant on various medical imaging technologies for non-invasively observing patients ’ anatomy. However, the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians. Moreover, some potentially useful quantitative information in medical images, especially that which is not visible to the naked eye, is often ignored during clinical prac tice. In contrast, radiomics performs high-throughput feature extraction from medical images, which enables quantitative analysis of medical images and prediction of various clinical endpoints. Studies have reported ...
Source: Military Medical Research - May 16, 2023 Category: International Medicine & Public Health Source Type: research
Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration
ConclusionsThese findings suggest that Ti-PDA@SNP-OGP is a promising multi-functional material for the high-efficient treatment of MRSA infections in implant replacement surgeries. (Source: Military Medical Research)
Source: Military Medical Research - May 4, 2023 Category: International Medicine & Public Health Source Type: research
Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
AbstractImmune checkpoint blockade (ICB) therapy for cancer has achieved great success both in clinical results and on the market. At the same time, success drives more attention from scientists to improve it. However, only a small portion of patients are responsive to this therapy, and it comes with a unique spectrum of side effects termed immune-related adverse events (irAEs). The use of nanotechnology could improve ICBs ’ delivery to the tumor, assist them in penetrating deeper into tumor tissues and alleviate their irAEs. Liposomal nanomedicine has been investigated and used for decades, and is well-recognized as th...
Source: Military Medical Research - April 28, 2023 Category: International Medicine & Public Health Source Type: research
