Mitochondrial quality control in human health and disease
AbstractMitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiological signals or external stimuli, a sophisticated mitochondrial quality control (MQC) mechanism has evolved, encompassing key processes like mitochondrial biogenesis, mitochondrial dynamics, and mitophagy, which have garnered increasing attention from researchers to unv...
Source: Military Medical Research - May 29, 2024 Category: International Medicine & Public Health Source Type: research
Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
AbstractAging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through a lens that encompasses both spatial and temporal dimensions. Conventional omics methodologies, such as genomics and transcriptomics, have been instrumental in identifying critical molecular facets of aging and regeneration. However, these methods are somewhat limited, constrained by their spatial resolution and their lack of capacity to dynamically represent tissue alterations. The advent of emerging spatiote...
Source: Military Medical Research - May 27, 2024 Category: International Medicine & Public Health Source Type: research
P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
ConclusionP. gingivalis was abundant in the Pf of patients with BPH concurrent periodontitis.P. gingivalis infection can promote BPH, which may affect the progression of BPH via inflammation and the Akt signaling pathway. (Source: Military Medical Research)
Source: Military Medical Research - May 20, 2024 Category: International Medicine & Public Health Source Type: research
Biomaterials science and surface engineering strategies for dental peri-implantitis management
AbstractPeri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antibacterial properties, and bacterial colonization and biofilm formation on the dental implants are major causes of peri-implantitis. Treatment strategies such as mechanical debridement and antibiotic therapy have been used to remove dental plaque. However, it is particularly important to prevent the occurrence of peri-implantitis rather than treatment. Therefore, the current research spot has focused on improving...
Source: Military Medical Research - May 13, 2024 Category: International Medicine & Public Health Source Type: research
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
ConclusionsIn summary, through integrated multiomics analysis, including both in vivo and in vitro experiments, this study demonstrated that mannose primarily exerts its anti-catabolic effects on IVDD through the TXNIP-glutamine axis. These findings provide strong evidence supporting the potential of the use of mannose in clinical applications for alleviating IVDD. Compared to existing clinically invasive or pain-relieving therapies for IVDD, the oral administration of mannose has characteristics that are more advantageous for clinical IVDD treatment. (Source: Military Medical Research)
Source: Military Medical Research - May 6, 2024 Category: International Medicine & Public Health Source Type: research
Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
ConclusionsThe present study revealed that neuronal Panx1 is a prominent driver of peripheral sensitivity in the setting of inflammatory pain through cell-autonomous effects on neuronal excitability. This hyperexcitability dependence on neuronal Panx1 contrasts with inflammatory orofacial pain, where similar studies revealed a prominent role for glial Panx1. The apparent differences in Panx1 expression in neuronal and non-neuronal TG and DRG cells are likely responsible for the distinct impact of these cell types in the two pain models. (Source: Military Medical Research)
Source: Military Medical Research - April 29, 2024 Category: International Medicine & Public Health Source Type: research
CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
(Source: Military Medical Research)
Source: Military Medical Research - April 23, 2024 Category: International Medicine & Public Health Source Type: research
N-terminal pro-brain natriuretic peptide – a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke
(Source: Military Medical Research)
Source: Military Medical Research - April 23, 2024 Category: International Medicine & Public Health Source Type: research
Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
AbstractSepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of intercellular communication, play a pivotal role in the pathogenesis of sepsis through modulating immune responses, metabolic reprogramming, coagulopathy, and organ dysfunction. This review highlights the emerging significance of exosomes in these processes. Initially, it provides an in-depth insight into exosome biogenesis and characterization, laying the groundwork for understanding their diverse and intricate functions. Subsequently, it explores the regulatory role...
Source: Military Medical Research - April 22, 2024 Category: International Medicine & Public Health Source Type: research
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
AbstractChronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of underlying comorbidities, such as diabetes or vascular diseases, lifestyle factors, and genetic risk profiles which may predispose extremities to local ischemia. Injuries are further exacerbated by bacterial colonization and the formation of biofilms. Infection, consequently, perpetuates a chronic inflammatory microenvironment, preventing the progression and completion of normal wound healing. The current standar...
Source: Military Medical Research - April 18, 2024 Category: International Medicine & Public Health Source Type: research
Interferon- α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
ConclusionsThis study provides mechanistic evidence that IFN- α stimulates DHX58 to promote the translation of m6A-modifiedGpx4 mRNA, suggesting the potential clinical application of IFN- α in the prevention of hepatic ferroptosis during liver I/R injury. (Source: Military Medical Research)
Source: Military Medical Research - April 15, 2024 Category: International Medicine & Public Health Source Type: research
The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
AbstractIn recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments in the current era, particularly the emerging integration of single-cell and spatiotemporal transcriptomics, have enabled a detailed molecular comprehension of the complex regulation of cell fate. The insights obtained from these methodologies are anticipated to significantly contribute to the development of personalized medicine. Currently, single-cell technology is less frequently utilized for prostate cancer compared with other types of tumors. Starting from the perspective of RNA sequencing technolog...
Source: Military Medical Research - April 11, 2024 Category: International Medicine & Public Health Source Type: research
FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
ConclusionsFOXO1high neutrophils represent a novel neutrophil phenotype that emerges in response to acute and chronic TBI, which provides insight into the heterogeneity, reprogramming activity, and versatility of neutrophils in TBI. (Source: Military Medical Research)
Source: Military Medical Research - March 31, 2024 Category: International Medicine & Public Health Source Type: research
Immune cells: potential carriers or agents for drug delivery to the central nervous system
AbstractDrug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous system (CNS) remains a challenge mainly due to the obstruction from brain barriers. Immune cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug delivery. Herein, we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood –brain barrier. We subsequently review biomimetic strategies ut...
Source: Military Medical Research - March 29, 2024 Category: International Medicine & Public Health Source Type: research
Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure
(Source: Military Medical Research)
Source: Military Medical Research - March 20, 2024 Category: International Medicine & Public Health Source Type: research
