Cholesterol transport and beyond: Illuminating the versatile functions of HDL apolipoproteins through structural insights and functional implications
High-density lipoproteins are versatile lipoprotein nanoparticles that have pleotropic functions in regulating lipid metabolism, innate immunity, and protection of cardiovascular system. They comprise of several proteins among which 15 apolipoproteins are the major proteins, with diverse functions. This review focuses on the structure, function, polymorphisms, and their role in human health and diseases and implications of developing novel therapeutic. AbstractHigh-density lipoproteins (HDLs) play a vital role in lipid metabolism and cardiovascular health, as they are intricately involved in cholesterol transport and infla...
Source: BioFactors - April 26, 2024 Category: Biochemistry Authors: Aishwarya Sudam Bhale,
Olivier Meilhac,
Christian Lefebvre d'Hellencourt,
Mookambeswaran A. Vijayalakshmi,
Krishnan Venkataraman Tags: REVIEW ARTICLE Source Type: research
BAG3 regulates cilia homeostasis of glioblastoma via its WW domain
Building on our previously identified and novel deciliating function of BAG3, we further decipher the molecular mechanisms of BAG3-regulated cilia homeostasis in glioblastoma (GBM). Based on identification of BAG3 interactomes and the contribution of different functional domains we now demonstrate that BAG3 regulates cilia homeostasis via its WW domain and modulation of YAP1 activity/downstream YAP1-dependent signaling. We also provide evidence for a complex interaction network of BAG3 with several pathways regulating cilia homeostasis at the level of ciliogenesis and cilium degradation. AbstractThe multidomain protein BAG...
Source: BioFactors - April 25, 2024 Category: Biochemistry Authors: Caterina Roth,
Lara Paulini,
Marina E. Hoffmann,
Thorsten Mosler,
Ivan Dikic,
Andreas Brunschweiger,
Hagen K örschgen,
Christian Behl,
Benedikt Linder,
Donat Kögel Tags: RESEARCH ARTICLE Source Type: research
Novel enzyme ‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice
In conclusion, Pro3 amino acid substitution of PP, either alone or together with mid-chain acylation, creates PP analogs with benefits on beta-cell rest, islet cell turnover, and energy regulation that may be applicable to the treatment of diabetes and obesity. (Source: BioFactors)
Source: BioFactors - April 19, 2024 Category: Biochemistry Authors: Wuyun Zhu,
Neil Tanday,
Ryan A. Lafferty,
Peter R. Flatt,
Nigel Irwin Tags: RESEARCH ARTICLE Source Type: research
Nerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK/AKT pathway
In conclusion, our study reveals for the first time that nerolidol can ameliorate hippocampal damage, neuroinflammation, synaptic, ER, and mitochondrial damage in diabetic rats. Furthermore, we suggest that nerolidol may inhibit NLRP3 inflammasome activation via MAPK and AKT signaling pathways. These findings provide a new experimental basis for the use of nerolidol to ameliorate diabetes-induced brain tissue damage and the associated disease. AbstractDespite the observation of diabetes-induced brain tissue damage and impaired learning and memory, the underlying mechanism of damage remains elusive, and effective, targeted ...
Source: BioFactors - April 17, 2024 Category: Biochemistry Authors: Yining Lei,
Manqin Li,
Xinran Liu,
Lu Zhang,
Ruyi Zhang,
Fei Cai Tags: RESEARCH ARTICLE Source Type: research
Issue Information
(Source: BioFactors)
Source: BioFactors - April 13, 2024 Category: Biochemistry Tags: ISSUE INFORMATION Source Type: research
Issue Information ‐ Cover
(Source: BioFactors)
Source: BioFactors - April 12, 2024 Category: Biochemistry Tags: ISSUE INFORMATION ‐ COVER Source Type: research
SP1/CTR1 ‐mediated oxidative stress‐induced cuproptosis in intervertebral disc degeneration
This study highlights the importance of cuproptosis in IDD progression and provides a promising therapeutic target for IDD treatment. (Source: BioFactors)
Source: BioFactors - April 11, 2024 Category: Biochemistry Authors: Xuanzuo Chen,
Kanglu Li,
Yan Xiao,
Wei Wu,
Hui Lin,
Xiangcheng Qing,
Shuo Tian,
Sheng Liu,
Shiqing Feng,
Baichuan Wang,
Zengwu Shao,
Yizhong Peng Tags: RESEARCH ARTICLE Source Type: research
Myokines: A central point in managing redox homeostasis and quality of life
The present review provides a comprehensive overview of skeletal muscle secreted myokines in managing redox homeostasis and quality of life. Additionally, probable strategies will be also discussed which provide a solution for betterment of life. AbstractRedox homeostasis is a crucial phenomenon that is obligatory for maintaining the healthy status of cells. However, the loss of redox homeostasis may lead to numerous diseases that ultimately result in a compromised quality of life. Skeletal muscle is an endocrine organ that secretes hundreds of myokines. Myokines are peptides and cytokines produced and released by muscle f...
Source: BioFactors - April 5, 2024 Category: Biochemistry Authors: Richa Rathor,
Geetha Suryakumar Tags: REVIEW ARTICLE Source Type: research
Soluble klotho induces the heat shock factor 1 through EGR1 expression
The transcription factor array approach was used to identify novel signaling pathways that are regulated by klotho gene/proteins. Klotho deficiency (kl−/−) largely decreased HSF1 levels and impaired heat shock protein expression. Additionally, klotho transcriptionally regulates HSF1 by modulating EGR-1. AbstractKlotho is an antiaging protein that has multiple functions. The purpose of this study is to investigate whether soluble klotho plays a role in cellular stress response pathways. We found that klotho deficiency (kl−/−) largely decreased HSF1 levels and impaired heat shock protein expression. Interestingly, re...
Source: BioFactors - April 4, 2024 Category: Biochemistry Authors: Soo ‐A Kim,
Nguyen Khanh Toan,
Sang‐Gun Ahn Tags: RESEARCH ARTICLE Source Type: research
SUMO ‐specific proteases: SENPs in oxidative stress‐related signaling and diseases
This article aims to illustrate the significant contribution of SENPs to the oxidative stress pathway through deSUMOylation by reviewing their structure and classification, their roles in oxidative stress, and the changes in their expression and activity in several typical oxida tive stress-related diseases. (Source: BioFactors)
Source: BioFactors - April 2, 2024 Category: Biochemistry Authors: Yaqi Jiao,
Xiaojuan Zhang,
Zhenshan Yang Tags: REVIEW ARTICLE Source Type: research
Indicaxanthin prevents eryptosis induced by cigarette smoke extract by interfering with active Fas ‐mediated signaling
In conclusion, Ind concentrations comparable to nutritionally relevant plasma concentrations, can prevent Fas-mediated RBC death signaling induced by CSE, which suggests that di etary intake of cactus pear fruits may limit the deleterious effects of cigarette smoking. (Source: BioFactors)
Source: BioFactors - March 24, 2024 Category: Biochemistry Authors: Ignazio Restivo,
Ilenia Concetta Giardina,
Rosario Barone,
Antonio Cilla,
Stefano Burgio,
Mario Allegra,
Luisa Tesoriere,
Alessandro Attanzio Tags: RESEARCH ARTICLE Source Type: research
Lactate dehydrogenase A is implicated in the pathogenesis of B ‐cell lymphoma through regulation of the FER signaling pathway
It is the first to report that LDHA may affect the metabolic activity of B-cell lymphoma through the FER pathway, such as mitochondrial membrane potential, ATP generation, and glycolysis, and further affect its proliferation, invasion, and in vivo development. It, therefore, provides new insights into potential therapeutic strategies targeting LDHA/FER for the treatment of B-cell lymphoma. AbstractLactate dehydrogenase A (LDHA) is highly expressed in various tumors. However, the role of LDHA in the pathogenesis of B-cell lymphoma remains unclear. Analysis of data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expr...
Source: BioFactors - March 23, 2024 Category: Biochemistry Authors: Xiumei Feng,
Jing Ren,
Xunqi Zhang,
Dexiao Kong,
Linlin Yin,
Qian Zhou,
Shunye Wang,
Ai Li,
Yanan Guo,
Yongjing Wang,
Xiaoli Feng,
Xiaoyun Wang,
Jianhua Niu,
Yang Jiang,
Chengyun Zheng Tags: RESEARCH ARTICLE Source Type: research
