Novel enzyme ‐resistant pancreatic polypeptide analogs evoke pancreatic beta‐cell rest, enhance islet cell turnover, and inhibit food intake in mice

In conclusion, Pro3 amino acid substitution of PP, either alone or together with mid-chain acylation, creates PP analogs with benefits on beta-cell rest, islet cell turnover, and energy regulation that may be applicable to the treatment of diabetes and obesity.

Source: BioFactors - April 19, 2024 Category: Biochemistry Authors: Wuyun Zhu, Neil Tanday, Ryan A. Lafferty, Peter R. Flatt, Nigel Irwin Tags: RESEARCH ARTICLE Source Type: research