Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration
We examined the predictive properties of PGS25OHD, and two scores related to DBP concentration with respect to 1322 health-related phenotypes and 315 laboratory-measured phenotypes from electronic health records. In those with European ancestry: (a) the PGS25OHD and PGSDBP scores, and individual SNPs rs4588 and rs7041 were associated with both 25OHD concentration and 1,25 dihydroxyvitamin D concentrations; (b) higher PGS25OHD was associated with decreased concentrations of triglycerides and cholesterol, and reduced risks of vitamin D deficiency, disorders of lipid metabolism, and diabetes. In general, the findings for the ...
Source: Twin Research and Human Genetics - April 22, 2024 Category: Genetics & Stem Cells Authors: Hailey A Kresge Freida Blostein Slavina Goleva Clara Albi ñana Joana A Revez Naomi R Wray Bjarni J Vilhj álmsson Zhihong Zhu John J McGrath Lea K Davis Source Type: research
Vitamin D: Synthesis, deficiency, polymorphisms and resistance to its action in Latin American countries
Biomedica. 2024 Mar 31;44(1):5-9. doi: 10.7705/biomedica.7477.NO ABSTRACTPMID:38648341 | DOI:10.7705/biomedica.7477 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - April 22, 2024 Category: International Medicine & Public Health Authors: Pedro Nel Rueda-Plata Source Type: research
Association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV) incidence and recurrence: a systematic review and meta-analysis
Conclusion
Results of this systematic review and meta-analysis demonstrated a negative correlation between serum vitamin D and BPPV incidence, while any relationship between serum vitamin D and BPPV recurrence remained uncertain. Risk of bias analysis revealed evidence of variable quality. There were insufficient data available to evaluate seasonal relationships between serum vitamin D and BPPV. Given the potential for this as a confounding factor, future research should aim to investigate this further.
PROSPERO registration number
CRD42021271840. (Source: BMJ Open)
Source: BMJ Open - April 22, 2024 Category: General Medicine Authors: Wood, H., Kluk, K., BinKhamis, G. Tags: Open access, Ear, nose and throat/otolaryngology Source Type: research
Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency
Vitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics profiling to study the relationship. (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 20, 2024 Category: OBGYN Authors: Xiaogang Li, Zhuoling An, Aimin Yao, Rui Li, Suhan Zhang, Songlin Yu, Liangkun Ma and Yanping Liu Tags: Research Source Type: research
The yield of routine laboratory examination in osteoporosis evaluation in primary care
ConclusionsWe identified a low prevalence of laboratory abnormalities in a primary care population of older women and the majority of these findings had no medical consequences. (Source: Osteoporosis International)
Source: Osteoporosis International - April 19, 2024 Category: Orthopaedics Source Type: research
The role of vitamin D against COVID-19 infection, progression and severity
CONCLUSION: People hospitalized for COVID-19 should be checked for vitamin D status and supplemented, and high-dose-in testing should be considered in the recovery trial. More importantly, screening for malnutrition and the administration of the best nutritional supplements are essential for the immune system of the human body to function as it should be. Thus, nutritional supplementation is crucial for people with risk factors as well as older adults with compromised immune systems.PMID:38640148 | DOI:10.3233/HAB-240009 (Source: Human Antibodies)
Source: Human Antibodies - April 19, 2024 Category: Biochemistry Authors: Hiba Sh Ahmed Hind Sh Ahmed Haylim N Abud Source Type: research
Viruses, Vol. 16, Pages 639: Vitamin D Levels and SARS-CoV-2 Infection among Medically Underserved Populations in the Minority and Rural Coronavirus Insights Study
Conclusion: Vitamin D levels were associated with an increased risk of SARS-CoV-2 infection. Hispanic/Latino and Black, non-Hispanic compared to White, non-Hispanic participants were at increased odds for infection, after adjusting for race/ethnicity and age. (Source: Viruses)
Source: Viruses - April 19, 2024 Category: Virology Authors: Makella S. Coudray Shantoy Hansel Salvatore Alesci William A. Meyer Robert H. Christenson Latrice G. Landry Christina Edwards Gary Puckrein Derrick J. Forney Ola Akinboboye Tags: Article Source Type: research
Vitamin D status of pregnant women with obesity in the United Kingdom and its association with pregnancy outcomes: a secondary analysis of the UPBEAT study
Br J Nutr. 2024 Apr 18:1-28. doi: 10.1017/S0007114524000862. Online ahead of print.ABSTRACTPrenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT), we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI≥30kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17±1 weeks' gestation were assessed using multivariable linear regression and reported as percent differences in serum hydroxyvitamin D (25(OH)D)....
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Karen M O'Callaghan Katarzyna G Nowak Kathryn V Dalrymple Lucilla Poston Jessica Rigutto-Farebrother Ola F Quotah Sara L White Angela C Flynn UPBEAT Consortium Source Type: research
The Role of Blood Testing in Prevention, Diagnosis, and Management of Chronic Diseases: A Review
Am J Med Sci. 2024 Apr 16:S0002-9629(24)01169-8. doi: 10.1016/j.amjms.2024.04.009. Online ahead of print.ABSTRACTBlood tests are vital to prevention, diagnosis, and management of chronic diseases. Despite this, it can be challenging to construct a comprehensive view of the clinical importance of blood testing because relevant literature is typically fragmented across different disease areas and patient populations. This lack of collated evidence can also make it difficult for primary care providers to adhere to best practices for blood testing across different diseases and guidelines. Thus, this review article synthesizes ...
Source: The American Journal of the Medical Sciences - April 18, 2024 Category: General Medicine Authors: Imelda Cabalar Thu H Le Abigail Silber Matthew O'Hara Bilal Abdallah Monisha Parikh Robert Busch Source Type: research
Vitamin D status of pregnant women with obesity in the United Kingdom and its association with pregnancy outcomes: a secondary analysis of the UPBEAT study
Br J Nutr. 2024 Apr 18:1-28. doi: 10.1017/S0007114524000862. Online ahead of print.ABSTRACTPrenatal vitamin D deficiency is widely reported and may affect perinatal outcomes. In this secondary analysis of the UK Pregnancies Better Eating and Activity Trial (UPBEAT), we examined vitamin D status and its relationship with selected pregnancy outcomes in women with obesity (BMI≥30kg/m2) from multi-ethnic inner-city settings in the UK. Determinants of vitamin D status at a mean of 17±1 weeks' gestation were assessed using multivariable linear regression and reported as percent differences in serum hydroxyvitamin D (25(OH)D)....
Source: The British Journal of Nutrition - April 18, 2024 Category: Nutrition Authors: Karen M O'Callaghan Katarzyna G Nowak Kathryn V Dalrymple Lucilla Poston Jessica Rigutto-Farebrother Ola F Quotah Sara L White Angela C Flynn UPBEAT Consortium Source Type: research
The effects of cholecalciferol and afamelanotide on vitamin D levels in erythropoietic protoporphyria; a multicentre cohort study
CONCLUSION: Cholecalciferol remains essential for treatment of vitamin D deficiency in EPP, irrespective of new treatment options like afamelanotide. Afamelanotide treatment did not affect vitamin D levels. We suggest that future guidelines include continuous monitoring of vitamin D and prescription of cholecalciferol in all patients with EPP, including those treated with afamelanotide.PMID:38634774 | DOI:10.1093/bjd/ljae148 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 18, 2024 Category: Dermatology Authors: Louisa G Kluijver Mitra Nekouei Shahraki Margreet A E M Wagenmakers Bettina E Hanssen Viola Kuerten Kathrin Schelonke Bernhard Homey Janneke G Langendonk Source Type: research
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research
Gene expression profiling of vitamin D metabolism enzymes in leukemia and lymphoma patients: molecular aspect interplay of VDR, CYP2R1, and CYP24A1
CONCLUSION: The study revealed a noteworthy difference in VDR protein levels between men and women. The highest mean CYP24A1 protein levels were observed in the age group > 60 years. This study found a significant, moderately positive correlation between VDR protein levels and CYP24A1 protein levels in the male and vitamin D sufficiency groups. In addition, a significant positive correlation was found between VDR mRNA levels and CYP2R1 mRNA levels, VDR mRNA levels and CYP2R1 mRNA levels, and CYP2R1 mRNA levels and CYP24A1 mRNA levels. However, the expression of these genes does not correlate with the protein levels of i...
Source: Molecular Biology Reports - April 17, 2024 Category: Molecular Biology Authors: Anggraini Iriani Andhika Rachman Marsya Kaila Fatina Rizka Kurnia Gemilang Andi Trisnandi Media Fitri Isma Nugraha Source Type: research
