Evaluation of Mitochondrial Function on Pyruvate Dehydrogenase Complex Deficient Patient-derived Cell Lines
CONCLUSIONS: This study showed that arginine and thiamine, at therapeutical levels, increase the basal oxygen consumption rate of PDC-deficient cell lines, as well as their ATP-linked respiration. This parameter measures the capacity of the cell to meet its energetic demands and, therefore, its increase reveals a higher electron flow through the respiratory chain, which is coupled to elevated oxidative phosphorylation, thus indicating an overall increased robustness in mitochondrial- related bioenergetics.PMID:37861030 | DOI:10.2174/0118715303280072231004082458 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 20, 2023 Category: Endocrinology Authors: Hana Pavl ú-Pereira Cristina Florindo Filipa Carvalho Isabel Tavares de Almeida Joao Vicente Vanessa Morais Isabel Rivera Source Type: research
Evaluation of Mitochondrial Function on Pyruvate Dehydrogenase Complex Deficient Patient-derived Cell Lines
CONCLUSIONS: This study showed that arginine and thiamine, at therapeutical levels, increase the basal oxygen consumption rate of PDC-deficient cell lines, as well as their ATP-linked respiration. This parameter measures the capacity of the cell to meet its energetic demands and, therefore, its increase reveals a higher electron flow through the respiratory chain, which is coupled to elevated oxidative phosphorylation, thus indicating an overall increased robustness in mitochondrial- related bioenergetics.PMID:37861030 | DOI:10.2174/0118715303280072231004082458 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Hana Pavl ú-Pereira Cristina Florindo Filipa Carvalho Isabel Tavares de Almeida Joao Vicente Vanessa Morais Isabel Rivera Source Type: research
Evaluation of Mitochondrial Function on Pyruvate Dehydrogenase Complex Deficient Patient-derived Cell Lines
CONCLUSIONS: This study showed that arginine and thiamine, at therapeutical levels, increase the basal oxygen consumption rate of PDC-deficient cell lines, as well as their ATP-linked respiration. This parameter measures the capacity of the cell to meet its energetic demands and, therefore, its increase reveals a higher electron flow through the respiratory chain, which is coupled to elevated oxidative phosphorylation, thus indicating an overall increased robustness in mitochondrial- related bioenergetics.PMID:37861030 | DOI:10.2174/0118715303280072231004082458 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 20, 2023 Category: Endocrinology Authors: Hana Pavl ú-Pereira Cristina Florindo Filipa Carvalho Isabel Tavares de Almeida Joao Vicente Vanessa Morais Isabel Rivera Source Type: research
Effects of dietary thiamin (vitamin B1) on the growth performance, serum biochemical factors, immune response, and antioxidant activity of great sturgeon (Huso huso) juveniles
AbstractThe present research evaluated the positive effects of dietary thiamin (vitamin B1) levels on the growth performance, serum biochemistry factors, immune response, and antioxidant activity of great sturgeon (Huso huso) juveniles. Thiamin was included in diets with levels of 0 (control, T0), 7 (T7), 15 (T15), and 25 (T25) mg/kg diet. Measurements of thiamin levels in diets indicated that they contained 1.80 (T0), 8.02 (T7), 16.2 (T15), and 26.6 (T25) mg thiamin/kg feed. Sturgeon juveniles (240 individuals) with average weight of 44.8 ± 1.96 g were distributed into 12 tanks, and fed with the experimental diets ...
Source: Veterinary Research Communications - October 16, 2023 Category: Veterinary Research Source Type: research
Fatal cerebral air embolism from atrio-oesophageal fistula following cardiac ablation
Pract Neurol. 2023 Oct 12:pn-2023-003915. doi: 10.1136/pn-2023-003915. Online ahead of print.ABSTRACTA young woman with Rogers syndrome (thiamine-responsive megaloblastic anaemia, diabetes mellitus and sensorineural deafness) presented with headache, recurrent supraventricular tachycardia and features of an upper gastrointestinal bleed, 1 month after radiofrequency cardiac ablation for supraventricular tachycardia. She deteriorated rapidly after endoscopy and subsequently died. Brain imaging during the acute deterioration showed diffuse intracranial air embolism and hypoxic-ischaemic injury. Postmortem examination showed a...
Source: Practical Neurology - October 12, 2023 Category: Neurology Authors: Ryan Yann Shern Keh Daniel du Plessis Gillian M Potter Christopher Kobylecki Paul Cooper Source Type: research
Fatal cerebral air embolism from atrio-oesophageal fistula following cardiac ablation
Pract Neurol. 2023 Oct 12:pn-2023-003915. doi: 10.1136/pn-2023-003915. Online ahead of print.ABSTRACTA young woman with Rogers syndrome (thiamine-responsive megaloblastic anaemia, diabetes mellitus and sensorineural deafness) presented with headache, recurrent supraventricular tachycardia and features of an upper gastrointestinal bleed, 1 month after radiofrequency cardiac ablation for supraventricular tachycardia. She deteriorated rapidly after endoscopy and subsequently died. Brain imaging during the acute deterioration showed diffuse intracranial air embolism and hypoxic-ischaemic injury. Postmortem examination showed a...
Source: Practical Neurology - October 12, 2023 Category: Neurology Authors: Ryan Yann Shern Keh Daniel du Plessis Gillian M Potter Christopher Kobylecki Paul Cooper Source Type: research
Fatal cerebral air embolism from atrio-oesophageal fistula following cardiac ablation
Pract Neurol. 2023 Oct 12:pn-2023-003915. doi: 10.1136/pn-2023-003915. Online ahead of print.ABSTRACTA young woman with Rogers syndrome (thiamine-responsive megaloblastic anaemia, diabetes mellitus and sensorineural deafness) presented with headache, recurrent supraventricular tachycardia and features of an upper gastrointestinal bleed, 1 month after radiofrequency cardiac ablation for supraventricular tachycardia. She deteriorated rapidly after endoscopy and subsequently died. Brain imaging during the acute deterioration showed diffuse intracranial air embolism and hypoxic-ischaemic injury. Postmortem examination showed a...
Source: Practical Neurology - October 12, 2023 Category: Neurology Authors: Ryan Yann Shern Keh Daniel du Plessis Gillian M Potter Christopher Kobylecki Paul Cooper Source Type: research
Fatal cerebral air embolism from atrio-oesophageal fistula following cardiac ablation
Pract Neurol. 2023 Oct 12:pn-2023-003915. doi: 10.1136/pn-2023-003915. Online ahead of print.ABSTRACTA young woman with Rogers syndrome (thiamine-responsive megaloblastic anaemia, diabetes mellitus and sensorineural deafness) presented with headache, recurrent supraventricular tachycardia and features of an upper gastrointestinal bleed, 1 month after radiofrequency cardiac ablation for supraventricular tachycardia. She deteriorated rapidly after endoscopy and subsequently died. Brain imaging during the acute deterioration showed diffuse intracranial air embolism and hypoxic-ischaemic injury. Postmortem examination showed a...
Source: Practical Neurology - October 12, 2023 Category: Neurology Authors: Ryan Yann Shern Keh Daniel du Plessis Gillian M Potter Christopher Kobylecki Paul Cooper Source Type: research
Wernicke ’s encephalopathy in acute and chronic kidney disease: a systematic review
Thiamine (vitamin B1) deficiency is relatively common in patients with kidney disease. Wernicke ’s encephalopathy (WE) is caused by vitamin B1 deficiency. Our aim was to systematically review the signs and symptoms of WE in patients with kidney disease. We conducted a systematic literature review on WE in kidney disease and recorded clinical and radiographic characteristics, treatment and ou tcome. In total 323 manuscripts were reviewed, which yielded 46 cases diagnosed with acute and chronic kidney disease and WE published in 37 reports. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 12, 2023 Category: Urology & Nephrology Authors: Erik Oudman, Jan W. Wijnia, David Severs, Misha J. Oey, Mirjam van Dam, Maaike van Dorp, Albert Postma Tags: Review Article Source Type: research
Wernicke's Encephalopathy in Acute and Chronic Kidney Disease: A Systematic Review
Thiamine (vitamin B1) deficiency is relatively common in patients with kidney disease. Wernicke's encephalopathy (WE) is caused by vitamin B1 deficiency. Our aim was to systematically review the signs and symptoms of WE in patients with kidney disease. We conducted a systematic literature review on WE in kidney disease and recorded clinical and radiographic characteristics, treatment and outcome. In total 323 manuscripts were reviewed, which yielded 46 cases diagnosed with acute and chronic kidney disease and WE published in 37 reports. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - October 12, 2023 Category: Urology & Nephrology Authors: Erik Oudman, Jan W. Wijnia, David Severs, Misha J. Oey, Mirjam van Dam, Maaike van Dorp, Albert Postma Tags: Review Article Source Type: research
Wernicke Encephalopathy After Bariatric Surgery: a Literature Review
AbstractWernicke encephalopathy (WE) is an acute neurological disorder classically characterized by ataxia, ophthalmoplegia, and altered mental status. This is caused by thiamine deficiency and is usually seen in malnourished populations. However, with the advent and rise of bariatric surgery in the last 50 years, WE has become an increasingly recognized and potentially deadly complication. Here, we review the populations at risk, clinical presentation, and the incidence of WE in the bariatric surgery population from 1985 to 2023. While the predominant procedure shifts throughout the years, the overa ll incidence of WE p...
Source: Obesity Surgery - October 6, 2023 Category: Surgery Source Type: research
A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial
In conclusion, 28 consecutive days of vitamin B complex (Ex PLUS®) supplementation significantly improved exercise endurance performance and reduced exercise fatigue biochemical metabolites in not athletes. In addition, it does not cause adverse effects in humans when taken at appropriate doses.PMID:37786445 | PMC:PMC10542023 | DOI:10.7150/ijms.86738 (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - October 3, 2023 Category: Biomedical Science Authors: Mon-Chien Lee Yi-Ju Hsu Sih-Yu Shen Chin-Shan Ho Chi-Chang Huang Source Type: research
Element and Water-Soluble Vitamins Profile of Rhus coriaria L. (Sumac) Grown in Different Regions
In this study, the amounts of some elements and water-soluble vitamins in Rhus coriaria L. (Sumac) samples grown in different regions were analyzed by ICP-OES and HPLC, respectively. The maximum amount of Na, K, Mg, and P was determined in the sumac samples of Kadana, Sheladize, Maraş, and Derishke regions, respectively. The richest regions in terms of trace elements such as Zn, Cu, Fe, Se, Mn, Cr, Mo, Ni, and B were Charput, Derishke, Ranya, Charput, Ranya, Derishke, Elazığ, Derishke, and Kadana, respectively. The highest amount of As, Cd, Pb, and Hg in sumac samples were determined in Kadana, Kadana, Trawanish, and Ch...
Source: Biological Trace Element Research - September 30, 2023 Category: Biology Authors: Haval Mohammed Ali Fikret Karata ş Dursun Özer Sinan Saydam Source Type: research
Element and Water-Soluble Vitamins Profile of Rhus coriaria L. (Sumac) Grown in Different Regions
In this study, the amounts of some elements and water-soluble vitamins in Rhus coriaria L. (Sumac) samples grown in different regions were analyzed by ICP-OES and HPLC, respectively. The maximum amount of Na, K, Mg, and P was determined in the sumac samples of Kadana, Sheladize, Maraş, and Derishke regions, respectively. The richest regions in terms of trace elements such as Zn, Cu, Fe, Se, Mn, Cr, Mo, Ni, and B were Charput, Derishke, Ranya, Charput, Ranya, Derishke, Elazığ, Derishke, and Kadana, respectively. The highest amount of As, Cd, Pb, and Hg in sumac samples were determined in Kadana, Kadana, Trawanish, and Ch...
Source: Biological Trace Element Research - September 30, 2023 Category: Biology Authors: Haval Mohammed Ali Fikret Karata ş Dursun Özer Sinan Saydam Source Type: research
