Evaluation of Mitochondrial Function on Pyruvate Dehydrogenase Complex Deficient Patient-derived Cell Lines

CONCLUSIONS: This study showed that arginine and thiamine, at therapeutical levels, increase the basal oxygen consumption rate of PDC-deficient cell lines, as well as their ATP-linked respiration. This parameter measures the capacity of the cell to meet its energetic demands and, therefore, its increase reveals a higher electron flow through the respiratory chain, which is coupled to elevated oxidative phosphorylation, thus indicating an overall increased robustness in mitochondrial- related bioenergetics.PMID:37861030 | DOI:10.2174/0118715303280072231004082458

Source: Endocrine, Metabolic and Immune Disorders Drug Targets - October 20, 2023 Category: Drugs & Pharmacology Authors: Hana Pavl ú-Pereira Cristina Florindo Filipa Carvalho Isabel Tavares de Almeida Joao Vicente Vanessa Morais Isabel Rivera Source Type: research