Macrophage P2Y6 receptor deletion attenuates atherosclerosis by limiting foam cell formation through phospholipase C β/store-operated calcium entry/calreticulin/scavenger receptor A pathways
CONCLUSIONS: Macrophage P2Y6R regulates phospholipase Cβ/store-operated calcium entry/calreticulin signalling pathway to increase scavenger receptor A protein level, thereby improving foam cell formation and atherosclerosis, indicating that the P2Y6R may be a potential therapeutic target for intervention of atherosclerotic diseases using P2Y6R antagonists including thiamine pyrophosphate.PMID:38036416 | DOI:10.1093/eurheartj/ehad796 (Source: Atherosclerosis)
Source: Atherosclerosis - November 30, 2023 Category: Cardiology Authors: Yehong Li Mengze Zhou Huanqiu Li Chen Dai Li Yin Chunxiao Liu Yuxin Li Enming Zhang Xinli Dong Hui Ji Qinghua Hu Source Type: research
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase
In this study, we show that an amino-oxetane bioisostere of the amide improves the affinity and maintains stability towards esterase-catalysed hydrolysis.PMID:38036274 | DOI:10.1016/j.bmcl.2023.129571 (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - November 30, 2023 Category: Chemistry Authors: Alex H Y Chan Terence C S Ho Finian J Leeper Source Type: research
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase
In this study, we show that an amino-oxetane bioisostere of the amide improves the affinity and maintains stability towards esterase-catalysed hydrolysis.PMID:38036274 | DOI:10.1016/j.bmcl.2023.129571 (Source: Bioorganic and Medicinal Chemistry Letters)
Source: Bioorganic and Medicinal Chemistry Letters - November 30, 2023 Category: Chemistry Authors: Alex H Y Chan Terence C S Ho Finian J Leeper Source Type: research
An Italian case series' description of thiamine responsive megaloblastic anemia syndrome: importance of early diagnosis and treatment
Individuals with thiamine-responsive megaloblastic anemia (TRMA) mainly manifest macrocytic anemia, sensorineural deafness, ocular complications, and nonautoimmune diabetes. Macrocytic anemia and diabetes may ... (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 30, 2023 Category: Pediatrics Authors: Francesca Di Candia, Valentina Di Iorio, Nadia Tinto, Riccardo Bonfanti, Claudio Iovino, Francesco Maria Rosanio, Ludovica Fedi, Fernanda Iafusco, Francesca Arrigoni, Rita Malesci, Francesca Simonelli, Andrea Rigamonti, Adriana Franzese and Enza Mozzillo Tags: Case report Source Type: research
An Italian case series' description of thiamine responsive megaloblastic anemia syndrome: importance of early diagnosis and treatment
ConclusionsEarly institution of high-dose thiamine supplementation seems to prevent the development of retinal changes and optic atrophy in TRMA patients. The spectrum of clinical manifestations is broad, and it is important to describe known Cases to gain a better understanding of this rare disease. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - November 30, 2023 Category: Pediatrics Source Type: research
Wernicke ’s Encephalopathy in the Absence of Alcohol Use
AbstractPurpose of ReviewThis review summarizes the clinical manifestations, diagnosis, and treatment of Wernicke ’s encephalopathy (WE) in the absence of alcohol use. Emergency physicians are well-acquainted with the disorder when associated with alcohol, but this reversible disease should be considered as part of the differential in numerous other patient populations.Recent FindingsTreatment for WE has not changed significantly, and standard of care continues to be high-dose thiamine, although dosing and duration vary between different society guidelines. Radiographic evidence of disease continues to evolve. More recen...
Source: Current Emergency and Hospital Medicine Reports - November 29, 2023 Category: Emergency Medicine Source Type: research
A case report of anorexia nervosa in a 23 ‐year‐old Ethiopian woman
Key Clinical MessagesLimited studies on AN in Africa, including Ethiopia. Internet and media have changed body image portrayal in developing countries. A need for a multidisciplinary approach to treatment, training on positive coaching styles, and future research.AbstractThe Global Burden of Disease had estimated anorexia nervosa (AN) or bulimia nervosa to be 13.6 million people. The lifetime prevalence of AN ranges from 2.4 to 4.3 percent. During their lifetime, up to 4% of females and up to 0.3% of males suffer from anorexia nervosa. Studies assessing AN in Africa, including Ethiopia, are limited. This case report descri...
Source: Clinical Case Reports - November 21, 2023 Category: General Medicine Authors: Selamawit Alemayehu Tessema,
Surafel Worku Megersa,
Meskerem Abebe,
Hailegiorgis Getnet Ayalew,
Melat Tigabu Tags: CASE REPORT Source Type: research
The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202309-1641LE. Online ahead of print.NO ABSTRACTPMID:37972375 | DOI:10.1164/rccm.202309-1641LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2023 Category: Respiratory Medicine Authors: Muhammad Ashraful Mumin Cathrine Anne McKenzie Peter Erwin Spronk Source Type: research
Reply to: The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202310-1740LE. Online ahead of print.NO ABSTRACTPMID:37972374 | DOI:10.1164/rccm.202310-1740LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2023 Category: Respiratory Medicine Authors: Ari Moskowitz Source Type: research
The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202309-1641LE. Online ahead of print.NO ABSTRACTPMID:37972375 | DOI:10.1164/rccm.202309-1641LE (Source: Respiratory Care)
Source: Respiratory Care - November 16, 2023 Category: Respiratory Medicine Authors: Muhammad Ashraful Mumin Cathrine Anne McKenzie Peter Erwin Spronk Source Type: research
Reply to: The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202310-1740LE. Online ahead of print.NO ABSTRACTPMID:37972374 | DOI:10.1164/rccm.202310-1740LE (Source: Respiratory Care)
Source: Respiratory Care - November 16, 2023 Category: Respiratory Medicine Authors: Ari Moskowitz Source Type: research
The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202309-1641LE. Online ahead of print.NO ABSTRACTPMID:37972375 | DOI:10.1164/rccm.202309-1641LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 16, 2023 Category: Intensive Care Authors: Muhammad Ashraful Mumin Cathrine Anne McKenzie Peter Erwin Spronk Source Type: research
Reply to: The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202310-1740LE. Online ahead of print.NO ABSTRACTPMID:37972374 | DOI:10.1164/rccm.202310-1740LE (Source: Am J Respir Crit Car...)
Source: Am J Respir Crit Car... - November 16, 2023 Category: Intensive Care Authors: Ari Moskowitz Source Type: research
The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202309-1641LE. Online ahead of print.NO ABSTRACTPMID:37972375 | DOI:10.1164/rccm.202309-1641LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2023 Category: Respiratory Medicine Authors: Muhammad Ashraful Mumin Cathrine Anne McKenzie Peter Erwin Spronk Source Type: research
Reply to: The Challenges of Using and Measuring Thiamine in Critical Care
Am J Respir Crit Care Med. 2023 Nov 16. doi: 10.1164/rccm.202310-1740LE. Online ahead of print.NO ABSTRACTPMID:37972374 | DOI:10.1164/rccm.202310-1740LE (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2023 Category: Respiratory Medicine Authors: Ari Moskowitz Source Type: research
