Marchiafava ‐Bignami disease: Prompt diagnosis made by magnetic resonance brain imaging
Key Clinical MessageMarchiafava-Bignami disease, a rare condition often associated with alcoholism, shows myelin degeneration with tissue necrosis specifically in the corpus callosum. Urgent application of magnetic resonance imaging could lead to prompt diagnosis.AbstractA 66-year-old male with habitual alcohol drink complained acute deterioration of left-side muscle weakness as initial presentation. On the arrival, the patient was confused, with stable vital sign and unremarkable pyramidal sign. Although several potential diagnoses could be considered, brain computed tomography did not provide diagnostic information, and ...
Source: Clinical Case Reports - April 17, 2024 Category: General Medicine Authors: Satori Akita,
Takeshi Takakuwa,
Kouji Kajinami Tags: CASE IMAGE Source Type: research
Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
CONCLUSION: MXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia.PMID:38622728 | DOI:10.1186/s40001-024-01777-9 (Source: Cell Research)
Source: Cell Research - April 15, 2024 Category: Cytology Authors: Shiying Zhang Bei Li Liuting Zeng Kailin Yang Junyao Jiang Fangguo Lu Ling Li Weiqing Li Source Type: research
Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology
ConclusionMXSGD may play an anti-inflammatory and immunoregulatory role by regulating intestinal microbiome and intestinal metabolic small molecules, and ultimately play a role in the treatment of influenza A virus pneumonia. (Source: European Journal of Medical Research)
Source: European Journal of Medical Research - April 15, 2024 Category: Research Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Validating nutrient selection for product-group-specific nutrient indices for use as functional units in life cycle assessment of foods
Br J Nutr. 2024 Apr 12:1-23. doi: 10.1017/S0007114524000709. Online ahead of print.ABSTRACTThe ability to provide adequate nutrition is considered a key factor in evaluating the sustainability of foods and diets. Nutrient indices are used as functional units (FUs) in life cycle assessment of foods to include nutritional performance in the environmental assessment of a product. Several general and food group-specific nutrient indices exist but many lack validation, particularly when used as FU. In addition, the nutrient selection strategies and reference units for nutrient intake can vary considerably among studies. To vali...
Source: The British Journal of Nutrition - April 12, 2024 Category: Nutrition Authors: Anna K årlund Venla Kytt ä Tiina Pellinen Hanna L Tuomisto Anne-Maria Pajari Marjukka Kolehmainen Merja Saarinen Source Type: research
Viruses, Vol. 16, Pages 582: Cardiometabolic Differences in People Living with HIV Receiving Integrase Strand Transfer Inhibitors Compared to Non-nucleoside Reverse Transcriptase Inhibitors: Implications for Current ART Strategies
er Ven
Willem L. Blok
Janneke E. Stalenhoef
In people living with HIV (PLHIV), integrase strand transfer inhibitors (INSTIs) are part of the first-line combination antiretroviral therapy (cART), while non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens are alternatives. Distinct cART regimens may variably influence the risk for non-AIDS comorbidities. We aimed to compare the metabolome and lipidome of INSTI and NNRTI-based regimens. The 2000HIV study includes asymptomatic PLHIV (n = 1646) on long-term cART, separated into a discovery cohort with 730 INSTI and 617 NNRTI users, and a validation coho...
Source: Viruses - April 10, 2024 Category: Virology Authors: Wilhelm A. J. W. Vos Nadira Vadaq Vasiliki Matzaraki Twan Otten Albert L. Groenendijk Marc J. T. Blaauw Louise E. van Eekeren Kees Brinkman Quirijn de Mast Niels P. Riksen Anton F. H. Stalenhoef Jan van Lunzen Andre J. A. M. van der Ven Willem L. Blok Jan Tags: Article Source Type: research
Management of Inoculation with < em > Bradyrhizobium japonicum < /em > and Application of Vitamins for Hydroponic Soybean Cultivation
Int J Microbiol. 2024 Mar 31;2024:4463693. doi: 10.1155/2024/4463693. eCollection 2024.ABSTRACTThe exchange of technologies used in field cultivation for hydroponic systems can potentially increase plant development and grain production, requiring studies to verify the best management forms, such as growth-promoting bacteria and biostimulant compounds. With this in mind, the study aimed to evaluate the effect of the application of thiamine and niacin, alone and combined, to soybean plants in the absence and presence of inoculation with B. japonicum on the agronomic and physiological characteristics of the crop grown in an ...
Source: International Journal of Microbiology - April 9, 2024 Category: Microbiology Authors: Alexandre H de F Lima Josiane S Salles Eduardo P Vendruscolo C ássio de C Seron Rog ério S de Freitas Sebasti ão F de Lima Gabriela R Sant'Ana Edilson Costa Source Type: research
The role of CT brain findings in the early diagnosis of infantile encephalitic beriberi
ConclusionRecognition of symmetrical hypodense lesions in the basal ganglia and medial thalami/hypothalamic/subthalamic area on noncontrast CT scan of the brain are important early features to recognize in encephalitic beriberi in at-risk infants.Advances in knowledgeIEBB is a cause of hypodense bilateral basal ganglia and may be identified by this finding in the appropriate clinical settings. (Source: Neuroradiology)
Source: Neuroradiology - April 1, 2024 Category: Radiology Source Type: research
High-dose oral thiamine versus placebo for chronic fatigue in patients with primary biliary cholangitis: A crossover randomized clinical trial
by Palle Bager, Lars Bossen, Rasmus Gantzel, Henning Gr ønbæk
Background& aimsFatigue has high negative impact on many patients with primary biliary cholangitis (PBC) and treatment options are limited. Recently we showed favorable effects of four weeks of high-dose thiamine treatment on fatigue in patients with inflammatory bowel disease. We aimed to investigate the effect and safety of high-dose (600 –1800 mg daily) oral thiamine treatment on chronic fatigue in patients with PBC. MethodsRandomized, double-blinded, placebo-controlled crossover trial including patients with severe PBC-related fatigue. Participants were ...
Source: PLoS One - March 29, 2024 Category: Biomedical Science Authors: Palle Bager Source Type: research
