Inhibition of acyl-CoA binding protein (ACBP) by means of a GABA < sub > A < /sub > R γ2-derived peptide
Cell Death Dis. 2024 Apr 6;15(4):249. doi: 10.1038/s41419-024-06633-6.ABSTRACTAcyl-CoA binding protein (ACBP) encoded by diazepam binding inhibitor (DBI) is an extracellular inhibitor of autophagy acting on the gamma-aminobutyric acid A receptor (GABAAR) γ2 subunit (GABAARγ2). Here, we show that lipoanabolic diets cause an upregulation of GABAARγ2 protein in liver hepatocytes but not in other major organs. ACBP/DBI inhibition by systemically injected antibodies has been demonstrated to mediate anorexigenic and organ-protective, autophagy-dependent effects. Here, we set out to develop a new strategy for developing ACBP/D...
Source: Cancer Control - April 6, 2024 Category: Cancer & Oncology Authors: Gerasimos Anagnostopoulos Ester Saavedra Flavia Lambertucci Omar Moti ño Jordan Dimitrov David Roiz-Valle Victor Quesada Karla Alvarez-Valadez Hui Chen Allan Sauvat Yan Rong Ux ía Nogueira-Recalde Sijing Li L éa Montégut Mojgan Djavaheri-Mergny Maria Source Type: research
Extrasynaptic GABA < sub > A < /sub > receptors in central medial thalamus mediate anesthesia in rats
Eur J Pharmacol. 2024 Apr 3:176561. doi: 10.1016/j.ejphar.2024.176561. Online ahead of print.ABSTRACTNeuronal depression in the thalamus underlies anesthetic-induced loss of consciousness, while the precise sub-thalamus nuclei and molecular targets involved remain to be elucidated. The present study investigated the role of extrasynaptic GABAA receptors in the central medial thalamic nucleus (CM) in anesthesia induced by gaboxadol (THIP) and diazepam (DZP) in rats. Local lesion of the CM led to a decrease in the duration of loss of righting reflex induced by THIP and DZP. CM microinjection of THIP but not DZP induced anest...
Source: European Journal of Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Alai Muheyati Shanshan Jiang Na Wang Gang Yu Ruibin Su Source Type: research
New-Onset Seizures and Psychosis in an Elderly Patient With No Seizure History in the Context of Low-Dose Diazepam Withdrawal
Prim Care Companion CNS Disord. 2024 Apr 4;26(2):23cr03654. doi: 10.4088/PCC.23cr03654.NO ABSTRACTPMID:38579253 | DOI:10.4088/PCC.23cr03654 (Source: Primary Care)
Source: Primary Care - April 5, 2024 Category: Primary Care Authors: Jiali Luan Babafemi Afolabi Source Type: research
New-Onset Seizures and Psychosis in an Elderly Patient With No Seizure History in the Context of Low-Dose Diazepam Withdrawal
Prim Care Companion CNS Disord. 2024 Apr 4;26(2):23cr03654. doi: 10.4088/PCC.23cr03654.NO ABSTRACTPMID:38579253 | DOI:10.4088/PCC.23cr03654 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - April 5, 2024 Category: Primary Care Authors: Jiali Luan Babafemi Afolabi Source Type: research
Extrasynaptic GABA < sub > A < /sub > receptors in central medial thalamus mediate anesthesia in rats
Eur J Pharmacol. 2024 Apr 3:176561. doi: 10.1016/j.ejphar.2024.176561. Online ahead of print.ABSTRACTNeuronal depression in the thalamus underlies anesthetic-induced loss of consciousness, while the precise sub-thalamus nuclei and molecular targets involved remain to be elucidated. The present study investigated the role of extrasynaptic GABAA receptors in the central medial thalamic nucleus (CM) in anesthesia induced by gaboxadol (THIP) and diazepam (DZP) in rats. Local lesion of the CM led to a decrease in the duration of loss of righting reflex induced by THIP and DZP. CM microinjection of THIP but not DZP induced anest...
Source: European Journal of Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Alai Muheyati Shanshan Jiang Na Wang Gang Yu Ruibin Su Source Type: research
New-Onset Seizures and Psychosis in an Elderly Patient With No Seizure History in the Context of Low-Dose Diazepam Withdrawal
Prim Care Companion CNS Disord. 2024 Apr 4;26(2):23cr03654. doi: 10.4088/PCC.23cr03654.NO ABSTRACTPMID:38579253 | DOI:10.4088/PCC.23cr03654 (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - April 5, 2024 Category: Primary Care Authors: Jiali Luan Babafemi Afolabi Source Type: research
Implementation of an intervention aimed at deprescribing benzodiazepines in a large US healthcare system using patient education materials: a pre/post-observational study with a control group
CONCLUSIONS: Results from this non-randomised QI initiative indicate that patient education programmes using the EMPOWER brochures have the potential to promote cessation of benzodiazepines in primary care.PMID:38569687 | DOI:10.1136/bmjopen-2023-080109 (Source: Pain Physician)
Source: Pain Physician - April 3, 2024 Category: Anesthesiology Authors: Tammy M Le Scott Campbell Alexa Andraos Pedro Ahlmark Ha Hoang Sean Isserman Caroline L Goldzweig Allison M Mays Kristin Bradley Michelle S Keller Source Type: research
Implementation of an intervention aimed at deprescribing benzodiazepines in a large US healthcare system using patient education materials: a pre/post-observational study with a control group
Conclusions
Results from this non-randomised QI initiative indicate that patient education programmes using the EMPOWER brochures have the potential to promote cessation of benzodiazepines in primary care. (Source: BMJ Open)
Source: BMJ Open - April 3, 2024 Category: General Medicine Authors: Le, T. M., Campbell, S., Andraos, A., Ahlmark, P., Hoang, H., Isserman, S., Goldzweig, C. L., Mays, A. M., Bradley, K., Keller, M. S. Tags: Open access, Health services research Source Type: research
Acute psychosis in a 35-year-old woman. Could it be related to a previous COVID-19 infection? A case report
Psychiatr Pol. 2023 Dec 31;57(6):1143-1149. doi: 10.12740/PP/152699. Epub 2023 Dec 31.ABSTRACTThe SARS-CoV-2 virus is the cause of the COVID-19 disease. Infection can take a wide variety of forms, from asymptomatic to severe, with numerous complications that can even lead to death. Since the beginning of the pandemic, numerous studies have been carried out to find out the exact expression of the virus. COVID-19 infection also increases the risk of developing neuropsychiatric symptoms, including psychosis. The paper presents the case of a 35-year-old woman with no prior psychiatric interview who developed acute psychosis af...
Source: Psychiatria Polska - April 2, 2024 Category: Psychiatry Authors: Iga Stok łosa Sylwia Bulanda Karolina Lau Jadwiga Jo śko-Ochojska Source Type: research
